Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7OOA

Mechanosensitive channel MscS solubilized with LMNG in open conformation with added lipid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
E	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
E	0016020	cellular_component	membrane
E	0055085	biological_process	transmembrane transport
F	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
F	0016020	cellular_component	membrane
F	0055085	biological_process	transmembrane transport
G	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
G	0016020	cellular_component	membrane
G	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue PEE A 301

Chain	Residue
A	MET56
A	ARG59
A	ILE61
A	VAL73
B	ALA103
B	VAL107
B	LMT301
B	AV0302

site_id	AC2
Number of Residues	8
Details	binding site for residue AV0 A 302

Chain	Residue
A	PHE127
B	SER114
B	LEU115
B	GLN149
B	ILE150
B	PHE151
B	AV0302
A	MET126

site_id	AC3
Number of Residues	3
Details	binding site for residue AV0 A 303

Chain	Residue
A	ASN30
A	VAL89
A	GLY90

site_id	AC4
Number of Residues	5
Details	binding site for residue LMT A 304

Chain	Residue
A	LEU42
A	ARG74
A	ILE78
G	ARG59
G	PEE303

site_id	AC5
Number of Residues	10
Details	binding site for residue AV0 A 305

Chain	Residue
A	PHE68
A	ALA71
A	ARG74
A	TYR75
A	ALA110
G	ILE61
G	ASP62
G	VAL65
G	PEE303
G	AV0304

site_id	AC6
Number of Residues	6
Details	binding site for residue LMT B 301

Chain	Residue
A	ARG59
A	PEE301
B	LEU42
B	ARG74
B	ILE78
B	LEU100

site_id	AC7
Number of Residues	9
Details	binding site for residue AV0 B 302

Chain	Residue
A	ILE61
A	ASP62
A	VAL65
A	PEE301
A	AV0302
B	ALA71
B	ARG74
B	TYR75
B	ALA110

site_id	AC8
Number of Residues	8
Details	binding site for residue PEE B 303

Chain	Residue
B	MET56
B	ARG59
B	ILE61
B	VAL73
C	ALA103
C	VAL107
C	LMT301
C	AV0302

site_id	AC9
Number of Residues	9
Details	binding site for residue AV0 B 304

Chain	Residue
B	MET126
B	PHE127
C	SER114
C	LEU115
C	LEU118
C	GLN149
C	ILE150
C	PHE151
C	AV0302

site_id	AD1
Number of Residues	3
Details	binding site for residue AV0 B 305

Chain	Residue
B	ASN30
B	VAL89
B	GLY90

site_id	AD2
Number of Residues	6
Details	binding site for residue LMT C 301

Chain	Residue
B	ARG59
B	PEE303
C	LEU42
C	ARG74
C	ILE78
C	LEU100

site_id	AD3
Number of Residues	10
Details	binding site for residue AV0 C 302

Chain	Residue
B	ILE61
B	ASP62
B	VAL65
B	PEE303
B	AV0304
C	ALA71
C	ARG74
C	TYR75
C	GLY108
C	ALA110

site_id	AD4
Number of Residues	6
Details	binding site for residue PEE C 303

Chain	Residue
C	MET56
C	ARG59
C	ILE61
C	VAL73
D	LMT301
D	AV0302

site_id	AD5
Number of Residues	5
Details	binding site for residue AV0 C 304

Chain	Residue
C	MET126
C	PHE127
D	GLN149
D	PHE151
D	AV0302

site_id	AD6
Number of Residues	3
Details	binding site for residue AV0 C 305

Chain	Residue
C	ASN30
C	VAL89
C	GLY90

site_id	AD7
Number of Residues	5
Details	binding site for residue LMT D 301

Chain	Residue
C	ARG59
C	PEE303
D	LEU42
D	ARG74
D	ILE78

site_id	AD8
Number of Residues	8
Details	binding site for residue AV0 D 302

Chain	Residue
C	ILE61
C	ASP62
C	VAL65
C	PEE303
C	AV0304
D	ALA71
D	ARG74
D	TYR75

site_id	AD9
Number of Residues	9
Details	binding site for residue PEE D 303

Chain	Residue
D	MET56
D	ARG59
D	ILE61
D	VAL73
E	ALA103
E	VAL107
E	LMT301
E	AV0302
F	ALA102

site_id	AE1
Number of Residues	9
Details	binding site for residue AV0 D 304

Chain	Residue
D	MET126
D	PHE127
E	SER114
E	LEU115
E	LEU118
E	GLN149
E	ILE150
E	PHE151
E	AV0302

site_id	AE2
Number of Residues	4
Details	binding site for residue AV0 D 305

Chain	Residue
C	ALA84
D	ASN30
D	VAL89
D	GLY90

site_id	AE3
Number of Residues	5
Details	binding site for residue LMT E 301

Chain	Residue
D	ARG59
D	PEE303
E	LEU42
E	ARG74
E	ILE78

site_id	AE4
Number of Residues	11
Details	binding site for residue AV0 E 302

Chain	Residue
D	ILE61
D	ASP62
D	VAL65
D	PEE303
D	AV0304
E	PHE68
E	ALA71
E	ARG74
E	TYR75
E	ALA110
E	LEU115

site_id	AE5
Number of Residues	8
Details	binding site for residue PEE E 303

Chain	Residue
E	MET56
E	ARG59
E	ILE61
E	VAL73
F	ALA103
F	VAL107
F	LMT301
F	AV0302

site_id	AE6
Number of Residues	10
Details	binding site for residue AV0 E 304

Chain	Residue
E	MET126
E	PHE127
F	LEU111
F	SER114
F	LEU115
F	LEU118
F	GLN149
F	ILE150
F	PHE151
F	AV0302

site_id	AE7
Number of Residues	3
Details	binding site for residue AV0 E 305

Chain	Residue
E	ASN30
E	VAL89
E	GLY90

site_id	AE8
Number of Residues	5
Details	binding site for residue LMT F 301

Chain	Residue
E	ARG59
E	PEE303
F	LEU42
F	ARG74
F	ILE78

site_id	AE9
Number of Residues	11
Details	binding site for residue AV0 F 302

Chain	Residue
E	ILE61
E	ASP62
E	VAL65
E	PEE303
E	AV0304
F	PHE68
F	ALA71
F	ARG74
F	TYR75
F	ALA110
F	LEU115

site_id	AF1
Number of Residues	9
Details	binding site for residue PEE F 303

Chain	Residue
A	ALA102
F	MET56
F	ARG59
F	ILE61
F	VAL73
G	ALA103
G	VAL107
G	LMT301
G	AV0302

site_id	AF2
Number of Residues	8
Details	binding site for residue AV0 F 304

Chain	Residue
F	MET126
F	PHE127
G	SER114
G	LEU115
G	LEU118
G	GLN149
G	PHE151
G	AV0302

site_id	AF3
Number of Residues	3
Details	binding site for residue AV0 F 305

Chain	Residue
F	ASN30
F	VAL89
F	GLY90

site_id	AF4
Number of Residues	6
Details	binding site for residue LMT G 301

Chain	Residue
F	ARG59
F	PEE303
G	LEU42
G	ARG74
G	ILE78
G	LEU100

site_id	AF5
Number of Residues	9
Details	binding site for residue AV0 G 302

Chain	Residue
F	ILE61
F	ASP62
F	VAL65
F	PEE303
F	AV0304
G	PHE68
G	ALA71
G	ARG74
G	TYR75

site_id	AF6
Number of Residues	6
Details	binding site for residue PEE G 303

Chain	Residue
A	LMT304
A	AV0305
G	MET56
G	ARG59
G	ILE61
G	VAL73

site_id	AF7
Number of Residues	6
Details	binding site for residue AV0 G 304

Chain	Residue
A	LEU111
A	GLN149
A	PHE151
A	AV0305
G	MET126
G	PHE127

site_id	AF8
Number of Residues	3
Details	binding site for residue AV0 G 305

Chain	Residue
G	ASN30
G	VAL89
G	GLY90

Functional Information from PROSITE/UniProt

site_id	PS01246
Number of Residues	35
Details	UPF0003 Uncharacterized protein family UPF0003 signature. GTVlsVqifsttMrtaDgkiIvIPNgkIIagniiN

Chain	Residue	Details
A	GLY143-ASN177

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)