Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7OO6

Mechanosensitive channel MscS solubilized with DDM in closed conformation with added lipid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
A	0009992	biological_process	intracellular water homeostasis
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0051260	biological_process	protein homooligomerization
A	0055085	biological_process	transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
B	0009992	biological_process	intracellular water homeostasis
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
C	0009992	biological_process	intracellular water homeostasis
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0051260	biological_process	protein homooligomerization
C	0055085	biological_process	transmembrane transport
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
D	0009992	biological_process	intracellular water homeostasis
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
E	0009992	biological_process	intracellular water homeostasis
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0051260	biological_process	protein homooligomerization
E	0055085	biological_process	transmembrane transport
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
F	0009992	biological_process	intracellular water homeostasis
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0042802	molecular_function	identical protein binding
F	0051260	biological_process	protein homooligomerization
F	0055085	biological_process	transmembrane transport
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
G	0009992	biological_process	intracellular water homeostasis
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0042802	molecular_function	identical protein binding
G	0051260	biological_process	protein homooligomerization
G	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue PCW A 801

Chain	Residue
A	ALA33
B	LMT802
A	VAL40
A	PHE80
A	ARG88
B	TYR27
B	ASN30
B	VAL89
B	GLN92
B	SER95

site_id	AC2
Number of Residues	10
Details	binding site for residue LMT A 802

Chain	Residue
A	GLY90
A	GLN92
A	THR93
A	ALA94
A	ALA102
B	GLN92
B	LMT802
G	GLY101
G	PCW801
G	LMT802

site_id	AC3
Number of Residues	13
Details	binding site for residue PCW B 801

Chain	Residue
B	ALA33
B	VAL40
B	PHE80
B	ARG88
C	TYR27
C	ASN30
C	ILE31
C	LEU86
C	VAL89
C	GLN92
C	SER95
C	VAL96
C	LMT802

site_id	AC4
Number of Residues	11
Details	binding site for residue LMT B 802

Chain	Residue
A	GLY101
A	LEU105
A	PCW801
A	LMT802
B	GLY90
B	GLN92
B	THR93
B	ALA94
B	ALA102
C	GLN92
C	LMT802

site_id	AC5
Number of Residues	13
Details	binding site for residue PCW C 801

Chain	Residue
C	ALA33
C	VAL40
C	PHE80
C	ARG88
D	TYR27
D	ASN30
D	ILE31
D	LEU86
D	VAL89
D	GLN92
D	SER95
D	VAL96
D	LMT802

site_id	AC6
Number of Residues	10
Details	binding site for residue LMT C 802

Chain	Residue
B	GLY101
B	PCW801
B	LMT802
C	GLY90
C	GLN92
C	THR93
C	ALA94
C	ALA102
D	GLN92
D	LMT802

site_id	AC7
Number of Residues	12
Details	binding site for residue PCW D 801

Chain	Residue
D	ALA33
D	VAL40
D	PHE80
D	ARG88
E	TYR27
E	ASN30
E	ILE31
E	LEU86
E	VAL89
E	GLN92
E	VAL96
E	LMT802

site_id	AC8
Number of Residues	11
Details	binding site for residue LMT D 802

Chain	Residue
C	GLY101
C	LEU105
C	PCW801
C	LMT802
D	GLY90
D	GLN92
D	THR93
D	ALA94
D	ALA102
E	GLN92
E	LMT802

site_id	AC9
Number of Residues	12
Details	binding site for residue PCW E 801

Chain	Residue
F	SER95
F	VAL96
F	LMT802
E	ALA33
E	VAL40
E	PHE80
E	ARG88
F	TYR27
F	ASN30
F	LEU86
F	VAL89
F	GLN92

site_id	AD1
Number of Residues	11
Details	binding site for residue LMT E 802

Chain	Residue
D	GLY101
D	LEU105
D	PCW801
D	LMT802
E	GLY90
E	GLN92
E	THR93
E	ALA94
E	ALA102
F	GLN92
F	LMT802

site_id	AD2
Number of Residues	12
Details	binding site for residue PCW F 801

Chain	Residue
F	ALA33
F	VAL40
F	PHE80
F	ARG88
G	TYR27
G	ASN30
G	LEU86
G	VAL89
G	GLN92
G	SER95
G	VAL96
G	LMT802

site_id	AD3
Number of Residues	11
Details	binding site for residue LMT F 802

Chain	Residue
E	GLY101
E	LEU105
E	PCW801
E	LMT802
F	GLY90
F	GLN92
F	THR93
F	ALA94
F	ALA102
G	GLN92
G	LMT802

site_id	AD4
Number of Residues	14
Details	binding site for residue PCW G 801

Chain	Residue
A	TYR27
A	ASN30
A	ILE31
A	LEU86
A	VAL89
A	VAL91
A	GLN92
A	SER95
A	VAL96
A	LMT802
G	ALA33
G	VAL40
G	PHE80
G	ARG88

site_id	AD5
Number of Residues	11
Details	binding site for residue LMT G 802

Chain	Residue
A	GLN92
A	LMT802
F	GLY101
F	LEU105
F	PCW801
F	LMT802
G	GLY90
G	GLN92
G	THR93
G	ALA94
G	ALA102

Functional Information from PROSITE/UniProt

site_id	PS01246
Number of Residues	35
Details	UPF0003 Uncharacterized protein family UPF0003 signature. GTVlsVqifsttMrtaDgkiIvIPNgkIIagniiN

Chain	Residue	Details
A	GLY143-ASN177

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	427
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"12446901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26551077","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	98
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	7
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)