Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7OO0

Mechanosensitive channel MscS solubilized with DDM in open conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
A	0009992	biological_process	intracellular water homeostasis
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0051260	biological_process	protein homooligomerization
A	0055085	biological_process	transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
B	0009992	biological_process	intracellular water homeostasis
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
C	0009992	biological_process	intracellular water homeostasis
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0051260	biological_process	protein homooligomerization
C	0055085	biological_process	transmembrane transport
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
D	0009992	biological_process	intracellular water homeostasis
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
E	0009992	biological_process	intracellular water homeostasis
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0051260	biological_process	protein homooligomerization
E	0055085	biological_process	transmembrane transport
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
F	0009992	biological_process	intracellular water homeostasis
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0042802	molecular_function	identical protein binding
F	0051260	biological_process	protein homooligomerization
F	0055085	biological_process	transmembrane transport
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
G	0009992	biological_process	intracellular water homeostasis
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0042802	molecular_function	identical protein binding
G	0051260	biological_process	protein homooligomerization
G	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue PEE A 301

Chain	Residue
A	MET56
B	LMT301
B	LMT305
A	ARG59
A	ILE61
A	LEU69
A	VAL73
A	LMT302
B	TYR75
B	LEU100
B	ALA103

site_id	AC2
Number of Residues	8
Details	binding site for residue LMT A 302

Chain	Residue
A	LYS60
A	ASP62
A	VAL65
A	LEU69
A	LEU118
A	MET126
A	PEE301
A	LMT305

site_id	AC3
Number of Residues	4
Details	binding site for residue LMT A 303

Chain	Residue
A	TYR27
A	ASN30
A	ILE31
A	VAL89

site_id	AC4
Number of Residues	6
Details	binding site for residue LMT A 304

Chain	Residue
A	TYR27
A	LEU86
A	VAL91
G	ALA84
G	ARG88
G	PEE404

site_id	AC5
Number of Residues	5
Details	binding site for residue LMT A 305

Chain	Residue
A	MET126
A	PHE127
A	LMT302
B	PHE68
B	PHE151

site_id	AC6
Number of Residues	9
Details	binding site for residue LMT A 306

Chain	Residue
A	GLY104
A	LEU109
A	GLN112
A	SER116
B	LEU105
B	LEU109
B	GLN112
B	LMT307
G	LMT401

site_id	AC7
Number of Residues	6
Details	binding site for residue LMT A 307

Chain	Residue
A	GLN92
A	THR93
A	ALA94
B	ALA94
B	LMT308
G	LMT402

site_id	AC8
Number of Residues	6
Details	binding site for residue LMT A 308

Chain	Residue
A	LEU42
A	ARG74
A	ILE78
G	LEU55
G	ARG59
G	PEE404

site_id	AC9
Number of Residues	6
Details	binding site for residue LMT B 301

Chain	Residue
A	LEU55
A	ARG59
A	PEE301
B	LEU42
B	ARG74
B	ILE78

site_id	AD1
Number of Residues	11
Details	binding site for residue PEE B 302

Chain	Residue
B	MET56
B	ARG59
B	ILE61
B	LEU69
B	VAL73
B	LMT303
C	TYR75
C	LEU100
C	ALA103
C	LMT301
C	LMT305

site_id	AD2
Number of Residues	8
Details	binding site for residue LMT B 303

Chain	Residue
B	LYS60
B	ASP62
B	VAL65
B	LEU69
B	LEU118
B	MET126
B	PEE302
B	LMT306

site_id	AD3
Number of Residues	4
Details	binding site for residue LMT B 304

Chain	Residue
B	TYR27
B	ASN30
B	ILE31
B	VAL89

site_id	AD4
Number of Residues	5
Details	binding site for residue LMT B 305

Chain	Residue
A	ARG88
A	PEE301
B	TYR27
B	LEU86
B	VAL91

site_id	AD5
Number of Residues	5
Details	binding site for residue LMT B 306

Chain	Residue
B	MET126
B	PHE127
B	LMT303
C	PHE68
C	PHE151

site_id	AD6
Number of Residues	9
Details	binding site for residue LMT B 307

Chain	Residue
C	LEU105
C	LEU109
C	GLN112
C	LMT307
A	LMT306
B	GLY104
B	LEU109
B	GLN112
B	SER116

site_id	AD7
Number of Residues	6
Details	binding site for residue LMT B 308

Chain	Residue
A	LMT307
B	GLN92
B	THR93
B	ALA94
C	ALA94
C	LMT308

site_id	AD8
Number of Residues	6
Details	binding site for residue LMT C 301

Chain	Residue
B	LEU55
B	ARG59
B	PEE302
C	LEU42
C	ARG74
C	ILE78

site_id	AD9
Number of Residues	11
Details	binding site for residue PEE C 302

Chain	Residue
C	MET56
C	ARG59
C	ILE61
C	LEU69
C	VAL73
C	LMT303
D	TYR75
D	GLY76
D	LEU100
D	LMT301
D	LMT305

site_id	AE1
Number of Residues	8
Details	binding site for residue LMT C 303

Chain	Residue
C	LYS60
C	ASP62
C	VAL65
C	LEU69
C	LEU118
C	MET126
C	PEE302
C	LMT306

site_id	AE2
Number of Residues	4
Details	binding site for residue LMT C 304

Chain	Residue
C	TYR27
C	ASN30
C	ILE31
C	VAL89

site_id	AE3
Number of Residues	5
Details	binding site for residue LMT C 305

Chain	Residue
B	ARG88
B	PEE302
C	TYR27
C	LEU86
C	VAL91

site_id	AE4
Number of Residues	4
Details	binding site for residue LMT C 306

Chain	Residue
C	MET126
C	PHE127
C	LMT303
D	PHE68

site_id	AE5
Number of Residues	9
Details	binding site for residue LMT C 307

Chain	Residue
B	LMT307
C	GLY104
C	LEU109
C	GLN112
C	SER116
D	LEU105
D	LEU109
D	GLN112
D	LMT307

site_id	AE6
Number of Residues	6
Details	binding site for residue LMT C 308

Chain	Residue
B	LMT308
C	GLN92
C	THR93
C	ALA94
D	ALA94
D	LMT308

site_id	AE7
Number of Residues	6
Details	binding site for residue LMT D 301

Chain	Residue
C	LEU55
C	ARG59
C	PEE302
D	LEU42
D	ARG74
D	ILE78

site_id	AE8
Number of Residues	10
Details	binding site for residue PEE D 302

Chain	Residue
D	MET56
D	ARG59
D	ILE61
D	LEU69
D	VAL73
D	LMT303
E	TYR75
E	LEU100
E	ALA103
E	LMT301

site_id	AE9
Number of Residues	9
Details	binding site for residue LMT D 303

Chain	Residue
D	LYS60
D	ASP62
D	VAL65
D	LEU69
D	LEU118
D	MET126
D	PEE302
D	LMT306
E	LEU111

site_id	AF1
Number of Residues	4
Details	binding site for residue LMT D 304

Chain	Residue
D	TYR27
D	ASN30
D	ILE31
D	VAL89

site_id	AF2
Number of Residues	6
Details	binding site for residue LMT D 305

Chain	Residue
C	ALA84
C	ARG88
C	PEE302
D	TYR27
D	LEU86
D	VAL91

site_id	AF3
Number of Residues	7
Details	binding site for residue LMT D 306

Chain	Residue
D	MET126
D	PHE127
D	LMT303
E	PHE68
E	LEU118
E	ILE150
E	PHE151

site_id	AF4
Number of Residues	9
Details	binding site for residue LMT D 307

Chain	Residue
C	LMT307
D	GLY104
D	LEU109
D	GLN112
D	SER116
E	LEU105
E	LEU109
E	GLN112
E	LMT307

site_id	AF5
Number of Residues	7
Details	binding site for residue LMT D 308

Chain	Residue
C	LMT308
D	GLN92
D	THR93
D	ALA94
D	ALA98
E	ALA94
E	LMT308

site_id	AF6
Number of Residues	8
Details	binding site for residue LMT E 301

Chain	Residue
D	LEU55
D	ARG59
D	PEE302
E	LEU42
E	ARG74
E	TYR75
E	ILE78
F	ALA102

site_id	AF7
Number of Residues	12
Details	binding site for residue PEE E 302

Chain	Residue
E	MET56
E	ARG59
E	ILE61
E	LEU69
E	VAL73
E	LMT303
F	TYR75
F	GLY76
F	LEU100
F	ALA103
F	LMT301
F	LMT305

site_id	AF8
Number of Residues	9
Details	binding site for residue LMT E 303

Chain	Residue
E	LYS60
E	ASP62
E	VAL65
E	LEU69
E	LEU118
E	MET126
E	PEE302
E	LMT306
F	LEU111

site_id	AF9
Number of Residues	4
Details	binding site for residue LMT E 304

Chain	Residue
E	TYR27
E	ASN30
E	ILE31
E	VAL89

site_id	AG1
Number of Residues	5
Details	binding site for residue LMT E 305

Chain	Residue
D	ALA84
D	ARG88
E	TYR27
E	LEU86
E	VAL91

site_id	AG2
Number of Residues	7
Details	binding site for residue LMT E 306

Chain	Residue
E	MET126
E	PHE127
E	LMT303
F	PHE68
F	LEU118
F	ILE150
F	PHE151

site_id	AG3
Number of Residues	10
Details	binding site for residue LMT E 307

Chain	Residue
D	LMT307
E	GLY104
E	GLY108
E	LEU109
E	GLN112
E	SER116
F	LEU105
F	LEU109
F	GLN112
G	LMT405

site_id	AG4
Number of Residues	7
Details	binding site for residue LMT E 308

Chain	Residue
D	LMT308
E	GLN92
E	THR93
E	ALA94
E	ALA98
F	ALA94
F	LMT307

site_id	AG5
Number of Residues	7
Details	binding site for residue LMT F 301

Chain	Residue
E	LEU55
E	ARG59
E	PEE302
F	LEU42
F	ARG74
F	TYR75
F	ILE78

site_id	AG6
Number of Residues	9
Details	binding site for residue PEE F 302

Chain	Residue
F	MET56
F	ARG59
F	ILE61
F	LEU69
F	VAL73
F	LMT303
G	TYR75
G	LMT403
G	LMT408

site_id	AG7
Number of Residues	8
Details	binding site for residue LMT F 303

Chain	Residue
F	LYS60
F	ASP62
F	VAL65
F	LEU69
F	LEU118
F	MET126
F	PEE302
F	LMT306

site_id	AG8
Number of Residues	4
Details	binding site for residue LMT F 304

Chain	Residue
F	TYR27
F	ASN30
F	ILE31
F	VAL89

site_id	AG9
Number of Residues	6
Details	binding site for residue LMT F 305

Chain	Residue
E	ALA84
E	ARG88
E	PEE302
F	TYR27
F	LEU86
F	VAL91

site_id	AH1
Number of Residues	6
Details	binding site for residue LMT F 306

Chain	Residue
F	MET126
F	PHE127
F	LMT303
G	PHE68
G	LEU118
G	PHE151

site_id	AH2
Number of Residues	5
Details	binding site for residue LMT F 307

Chain	Residue
E	LMT308
F	GLN92
F	ALA94
G	ALA94
G	LMT402

site_id	AH3
Number of Residues	10
Details	binding site for residue LMT G 401

Chain	Residue
A	LEU105
A	LEU109
A	GLN112
A	LMT306
G	GLY104
G	GLY108
G	LEU109
G	GLN112
G	SER116
G	LMT405

site_id	AH4
Number of Residues	7
Details	binding site for residue LMT G 402

Chain	Residue
A	ALA94
A	LMT307
F	LMT307
G	GLN92
G	THR93
G	ALA94
G	ALA98

site_id	AH5
Number of Residues	6
Details	binding site for residue LMT G 403

Chain	Residue
F	LEU55
F	ARG59
F	PEE302
G	LEU42
G	ARG74
G	ILE78

site_id	AH6
Number of Residues	11
Details	binding site for residue PEE G 404

Chain	Residue
A	TYR75
A	GLY76
A	LEU100
A	LMT304
A	LMT308
G	MET56
G	ARG59
G	ILE61
G	LEU69
G	VAL73
G	LMT406

site_id	AH7
Number of Residues	9
Details	binding site for residue LMT G 405

Chain	Residue
E	LMT307
F	GLY104
F	LEU109
F	GLN112
F	SER116
G	LEU105
G	LEU109
G	GLN112
G	LMT401

site_id	AH8
Number of Residues	8
Details	binding site for residue LMT G 406

Chain	Residue
G	LYS60
G	ASP62
G	VAL65
G	LEU69
G	LEU118
G	MET126
G	PEE404
G	LMT409

site_id	AH9
Number of Residues	4
Details	binding site for residue LMT G 407

Chain	Residue
G	TYR27
G	ASN30
G	ILE31
G	VAL89

site_id	AI1
Number of Residues	6
Details	binding site for residue LMT G 408

Chain	Residue
F	ALA84
F	ARG88
F	PEE302
G	TYR27
G	LEU86
G	VAL91

site_id	AI2
Number of Residues	4
Details	binding site for residue LMT G 409

Chain	Residue
A	PHE68
G	MET126
G	PHE127
G	LMT406

Functional Information from PROSITE/UniProt

site_id	PS01246
Number of Residues	35
Details	UPF0003 Uncharacterized protein family UPF0003 signature. GTVlsVqifsttMrtaDgkiIvIPNgkIIagniiN

Chain	Residue	Details
A	GLY143-ASN177

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	427
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"12446901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26551077","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	98
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	7
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)