Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7ONJ

Mechanosensitive channel MscS solubilized with LMNG in open conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
E	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
E	0016020	cellular_component	membrane
E	0055085	biological_process	transmembrane transport
F	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
F	0016020	cellular_component	membrane
F	0055085	biological_process	transmembrane transport
G	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
G	0016020	cellular_component	membrane
G	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PEE A 301

Chain	Residue
A	MET56
A	ARG59
A	ILE61
B	LMT301
B	AV0302
B	LMT308

site_id	AC2
Number of Residues	8
Details	binding site for residue LMT A 302

Chain	Residue
B	LMT304
F	LMT401
G	GLY101
G	ALA102
G	LMT404
A	THR93
A	ALA94
A	ILE97

site_id	AC3
Number of Residues	7
Details	binding site for residue AV0 A 303

Chain	Residue
A	MET126
A	PHE127
B	LEU111
B	LEU115
B	GLN149
B	ILE150
B	AV0302

site_id	AC4
Number of Residues	5
Details	binding site for residue AV0 A 304

Chain	Residue
A	TYR27
A	ASN30
A	VAL89
A	GLY90
A	AV0305

site_id	AC5
Number of Residues	8
Details	binding site for residue AV0 A 305

Chain	Residue
A	TYR27
A	GLN92
A	AV0304
G	ALA36
G	VAL40
G	GLY87
G	ARG88
G	AV0402

site_id	AC6
Number of Residues	5
Details	binding site for residue LMT A 306

Chain	Residue
A	LEU42
A	ARG74
G	LEU55
G	ARG59
G	PEE403

site_id	AC7
Number of Residues	8
Details	binding site for residue AV0 A 307

Chain	Residue
A	ARG74
A	TYR75
A	ALA110
A	LEU115
G	ASP62
G	PHE68
G	PEE403
G	AV0405

site_id	AC8
Number of Residues	8
Details	binding site for residue LMT A 308

Chain	Residue
A	GLY104
A	LEU109
A	GLN112
A	SER116
B	LEU109
B	GLN112
B	LMT308
G	LMT401

site_id	AC9
Number of Residues	3
Details	binding site for residue AV0 A 309

Chain	Residue
A	VAL29
A	ARG88
B	AV0307

site_id	AD1
Number of Residues	9
Details	binding site for residue LMT G 401

Chain	Residue
A	LEU109
A	GLN112
A	LMT308
F	LMT401
F	PEE405
G	GLY104
G	LEU109
G	GLN112
G	SER116

site_id	AD2
Number of Residues	3
Details	binding site for residue AV0 G 402

Chain	Residue
A	AV0305
G	VAL29
G	ARG88

site_id	AD3
Number of Residues	7
Details	binding site for residue PEE G 403

Chain	Residue
A	LEU72
A	GLY76
A	LMT306
A	AV0307
G	MET56
G	ARG59
G	ILE61

site_id	AD4
Number of Residues	6
Details	binding site for residue LMT G 404

Chain	Residue
A	ALA94
A	LMT302
F	LMT406
G	THR93
G	ALA94
G	ILE97

site_id	AD5
Number of Residues	5
Details	binding site for residue AV0 G 405

Chain	Residue
A	GLN149
A	ILE150
A	AV0307
G	MET126
G	PHE127

site_id	AD6
Number of Residues	5
Details	binding site for residue AV0 G 406

Chain	Residue
G	TYR27
G	ASN30
G	VAL89
G	GLY90
G	AV0407

site_id	AD7
Number of Residues	7
Details	binding site for residue AV0 G 407

Chain	Residue
G	AV0406
F	ALA36
F	GLY87
F	ARG88
F	AV0402
G	TYR27
G	GLN92

site_id	AD8
Number of Residues	5
Details	binding site for residue LMT G 408

Chain	Residue
F	LEU55
F	ARG59
F	PEE405
G	LEU42
G	ARG74

site_id	AD9
Number of Residues	9
Details	binding site for residue AV0 G 409

Chain	Residue
F	ASP62
F	PHE68
F	PEE405
F	AV0407
G	ARG74
G	TYR75
G	GLY108
G	LEU115
G	HOH513

site_id	AE1
Number of Residues	5
Details	binding site for residue LMT B 301

Chain	Residue
A	LEU55
A	ARG59
A	PEE301
B	LEU42
B	ARG74

site_id	AE2
Number of Residues	9
Details	binding site for residue AV0 B 302

Chain	Residue
A	ASP62
A	PHE68
A	PEE301
A	AV0303
B	ARG74
B	TYR75
B	GLY108
B	ALA110
B	LEU115

site_id	AE3
Number of Residues	7
Details	binding site for residue PEE B 303

Chain	Residue
B	MET56
B	ARG59
B	ILE61
C	ALA103
C	LMT301
C	AV0302
C	LMT308

site_id	AE4
Number of Residues	5
Details	binding site for residue LMT B 304

Chain	Residue
A	LMT302
B	THR93
B	ALA94
B	ILE97
C	LMT304

site_id	AE5
Number of Residues	7
Details	binding site for residue AV0 B 305

Chain	Residue
B	MET126
B	PHE127
C	LEU111
C	LEU115
C	GLN149
C	ILE150
C	AV0302

site_id	AE6
Number of Residues	5
Details	binding site for residue AV0 B 306

Chain	Residue
B	TYR27
B	ASN30
B	VAL89
B	GLY90
B	AV0307

site_id	AE7
Number of Residues	6
Details	binding site for residue AV0 B 307

Chain	Residue
A	GLY87
A	ARG88
A	AV0309
B	TYR27
B	GLN92
B	AV0306

site_id	AE8
Number of Residues	9
Details	binding site for residue LMT B 308

Chain	Residue
A	PEE301
A	LMT308
B	GLY104
B	GLN112
B	SER116
C	LEU109
C	GLN112
C	LMT308
D	LMT304

site_id	AE9
Number of Residues	3
Details	binding site for residue AV0 B 309

Chain	Residue
B	VAL29
B	ARG88
C	AV0307

site_id	AF1
Number of Residues	5
Details	binding site for residue LMT C 301

Chain	Residue
B	LEU55
B	ARG59
B	PEE303
C	LEU42
C	ARG74

site_id	AF2
Number of Residues	9
Details	binding site for residue AV0 C 302

Chain	Residue
B	ASP62
B	PHE68
B	PEE303
B	AV0305
C	ARG74
C	TYR75
C	GLY108
C	ALA110
C	LEU115

site_id	AF3
Number of Residues	7
Details	binding site for residue PEE C 303

Chain	Residue
C	MET56
C	ARG59
C	ILE61
D	LEU72
D	GLY76
D	LMT301
D	AV0302

site_id	AF4
Number of Residues	6
Details	binding site for residue LMT C 304

Chain	Residue
B	LMT304
C	THR93
C	ALA94
C	ILE97
D	ALA94
D	LMT304

site_id	AF5
Number of Residues	5
Details	binding site for residue AV0 C 305

Chain	Residue
C	MET126
C	PHE127
D	GLN149
D	ILE150
D	AV0302

site_id	AF6
Number of Residues	5
Details	binding site for residue AV0 C 306

Chain	Residue
C	TYR27
C	ASN30
C	VAL89
C	GLY90
C	AV0307

site_id	AF7
Number of Residues	7
Details	binding site for residue AV0 C 307

Chain	Residue
B	VAL40
B	GLY87
B	ARG88
B	AV0309
C	TYR27
C	GLN92
C	AV0306

site_id	AF8
Number of Residues	9
Details	binding site for residue LMT C 308

Chain	Residue
B	PEE303
B	LMT308
C	GLY104
C	LEU109
C	GLN112
C	SER116
D	LEU109
D	GLN112
D	LMT308

site_id	AF9
Number of Residues	3
Details	binding site for residue AV0 C 309

Chain	Residue
C	VAL29
C	ARG88
D	AV0307

site_id	AG1
Number of Residues	5
Details	binding site for residue LMT D 301

Chain	Residue
C	LEU55
C	ARG59
C	PEE303
D	LEU42
D	ARG74

site_id	AG2
Number of Residues	8
Details	binding site for residue AV0 D 302

Chain	Residue
C	ASP62
C	PHE68
C	PEE303
C	AV0305
D	ARG74
D	TYR75
D	GLY108
D	ALA110

site_id	AG3
Number of Residues	6
Details	binding site for residue PEE D 303

Chain	Residue
D	MET56
D	ARG59
D	ILE61
E	LMT301
E	AV0302
E	LMT308

site_id	AG4
Number of Residues	7
Details	binding site for residue LMT D 304

Chain	Residue
B	LMT308
C	LMT304
D	THR93
D	ALA94
D	ILE97
E	ALA94
E	LMT304

site_id	AG5
Number of Residues	7
Details	binding site for residue AV0 D 305

Chain	Residue
D	MET126
D	PHE127
E	LEU111
E	LEU115
E	GLN149
E	ILE150
E	AV0302

site_id	AG6
Number of Residues	5
Details	binding site for residue AV0 D 306

Chain	Residue
D	TYR27
D	ASN30
D	VAL89
D	GLY90
D	AV0307

site_id	AG7
Number of Residues	8
Details	binding site for residue AV0 D 307

Chain	Residue
C	ALA36
C	VAL40
C	GLY87
C	ARG88
C	AV0309
D	TYR27
D	GLN92
D	AV0306

site_id	AG8
Number of Residues	8
Details	binding site for residue LMT D 308

Chain	Residue
C	LMT308
D	GLY104
D	LEU109
D	GLN112
D	SER116
E	LEU109
E	GLN112
E	LMT308

site_id	AG9
Number of Residues	3
Details	binding site for residue AV0 D 309

Chain	Residue
D	VAL29
D	ARG88
E	AV0307

site_id	AH1
Number of Residues	7
Details	binding site for residue LMT E 301

Chain	Residue
D	LEU55
D	ARG59
D	PEE303
E	LEU42
E	ARG74
E	TYR75
F	ALA102

site_id	AH2
Number of Residues	10
Details	binding site for residue AV0 E 302

Chain	Residue
D	ASP62
D	PHE68
D	PEE303
D	AV0305
E	ARG74
E	TYR75
E	GLY108
E	ALA110
E	LEU115
E	HOH413

site_id	AH3
Number of Residues	7
Details	binding site for residue PEE E 303

Chain	Residue
E	MET56
E	ARG59
E	ILE61
F	LEU72
F	ALA103
F	LMT403
F	AV0404

site_id	AH4
Number of Residues	6
Details	binding site for residue LMT E 304

Chain	Residue
D	LMT304
E	THR93
E	ALA94
E	ILE97
F	ALA94
F	LMT406

site_id	AH5
Number of Residues	6
Details	binding site for residue AV0 E 305

Chain	Residue
E	MET126
E	PHE127
F	LEU115
F	GLN149
F	ILE150
F	AV0404

site_id	AH6
Number of Residues	5
Details	binding site for residue AV0 E 306

Chain	Residue
E	TYR27
E	ASN30
E	VAL89
E	GLY90
E	AV0307

site_id	AH7
Number of Residues	8
Details	binding site for residue AV0 E 307

Chain	Residue
D	ALA36
D	VAL40
D	GLY87
D	ARG88
D	AV0309
E	TYR27
E	GLN92
E	AV0306

site_id	AH8
Number of Residues	9
Details	binding site for residue LMT E 308

Chain	Residue
D	PEE303
D	LMT308
E	GLY104
E	LEU109
E	GLN112
E	SER116
F	LEU109
F	GLN112
F	LMT401

site_id	AH9
Number of Residues	3
Details	binding site for residue AV0 E 309

Chain	Residue
E	VAL29
E	ARG88
F	AV0409

site_id	AI1
Number of Residues	8
Details	binding site for residue LMT F 401

Chain	Residue
A	LMT302
E	LMT308
F	LEU109
F	GLN112
F	SER116
G	LEU109
G	GLN112
G	LMT401

site_id	AI2
Number of Residues	3
Details	binding site for residue AV0 F 402

Chain	Residue
F	VAL29
F	ARG88
G	AV0407

site_id	AI3
Number of Residues	6
Details	binding site for residue LMT F 403

Chain	Residue
E	LEU55
E	ARG59
E	PEE303
F	LEU42
F	ARG74
F	TYR75

site_id	AI4
Number of Residues	8
Details	binding site for residue AV0 F 404

Chain	Residue
E	ASP62
E	PHE68
E	PEE303
E	AV0305
F	ARG74
F	TYR75
F	ALA110
F	LEU115

site_id	AI5
Number of Residues	6
Details	binding site for residue PEE F 405

Chain	Residue
F	MET56
F	ARG59
F	ILE61
G	LMT401
G	LMT408
G	AV0409

site_id	AI6
Number of Residues	6
Details	binding site for residue LMT F 406

Chain	Residue
E	ALA102
E	LMT304
F	THR93
F	ALA94
F	ILE97
G	LMT404

site_id	AI7
Number of Residues	7
Details	binding site for residue AV0 F 407

Chain	Residue
F	MET126
F	PHE127
G	LEU111
G	LEU115
G	GLN149
G	ILE150
G	AV0409

site_id	AI8
Number of Residues	5
Details	binding site for residue AV0 F 408

Chain	Residue
F	TYR27
F	ASN30
F	VAL89
F	GLY90
F	AV0409

site_id	AI9
Number of Residues	8
Details	binding site for residue AV0 F 409

Chain	Residue
E	ALA36
E	VAL40
E	GLY87
E	ARG88
E	AV0309
F	TYR27
F	GLN92
F	AV0408

Functional Information from PROSITE/UniProt

site_id	PS01246
Number of Residues	35
Details	UPF0003 Uncharacterized protein family UPF0003 signature. GTVlsVqifsttMrtaDgkiIvIPNgkIIagniiN

Chain	Residue	Details
A	GLY143-ASN177

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)