7ONB
Structure of the U2 5' module of the A3'-SSA complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000124 | cellular_component | SAGA complex |
| A | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| A | 0000398 | biological_process | mRNA splicing, via spliceosome |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005681 | cellular_component | spliceosomal complex |
| A | 0005684 | cellular_component | U2-type spliceosomal complex |
| A | 0005686 | cellular_component | U2 snRNP |
| A | 0005689 | cellular_component | U12-type spliceosomal complex |
| A | 0005730 | cellular_component | nucleolus |
| A | 0006282 | biological_process | regulation of DNA repair |
| A | 0006397 | biological_process | mRNA processing |
| A | 0008380 | biological_process | RNA splicing |
| A | 0030620 | molecular_function | U2 snRNA binding |
| A | 0042177 | biological_process | negative regulation of protein catabolic process |
| A | 0043484 | biological_process | regulation of RNA splicing |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| A | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| A | 0071013 | cellular_component | catalytic step 2 spliceosome |
| A | 1903241 | biological_process | U2-type prespliceosome assembly |
| B | 0000124 | cellular_component | SAGA complex |
| B | 0000398 | biological_process | mRNA splicing, via spliceosome |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005681 | cellular_component | spliceosomal complex |
| B | 0005684 | cellular_component | U2-type spliceosomal complex |
| B | 0005686 | cellular_component | U2 snRNP |
| B | 0005689 | cellular_component | U12-type spliceosomal complex |
| B | 0006282 | biological_process | regulation of DNA repair |
| B | 0006397 | biological_process | mRNA processing |
| B | 0008380 | biological_process | RNA splicing |
| B | 0043484 | biological_process | regulation of RNA splicing |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| B | 0071011 | cellular_component | precatalytic spliceosome |
| B | 1903241 | biological_process | U2-type prespliceosome assembly |
| B | 1990935 | molecular_function | splicing factor binding |
| C | 0000245 | biological_process | spliceosomal complex assembly |
| C | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| C | 0000398 | biological_process | mRNA splicing, via spliceosome |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003729 | molecular_function | mRNA binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005681 | cellular_component | spliceosomal complex |
| C | 0005684 | cellular_component | U2-type spliceosomal complex |
| C | 0005686 | cellular_component | U2 snRNP |
| C | 0005689 | cellular_component | U12-type spliceosomal complex |
| C | 0005730 | cellular_component | nucleolus |
| C | 0006338 | biological_process | chromatin remodeling |
| C | 0006397 | biological_process | mRNA processing |
| C | 0008380 | biological_process | RNA splicing |
| C | 0016607 | cellular_component | nuclear speck |
| C | 0034693 | cellular_component | U11/U12 snRNP |
| C | 0045943 | biological_process | positive regulation of transcription by RNA polymerase I |
| C | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| C | 0045945 | biological_process | positive regulation of transcription by RNA polymerase III |
| C | 0071004 | cellular_component | U2-type prespliceosome |
| C | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| C | 0071013 | cellular_component | catalytic step 2 spliceosome |
| C | 0110016 | cellular_component | B-WICH complex |
| C | 1903241 | biological_process | U2-type prespliceosome assembly |
| C | 1990935 | molecular_function | splicing factor binding |
| D | 0000398 | biological_process | mRNA splicing, via spliceosome |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005681 | cellular_component | spliceosomal complex |
| D | 0005684 | cellular_component | U2-type spliceosomal complex |
| D | 0005686 | cellular_component | U2 snRNP |
| D | 0005689 | cellular_component | U12-type spliceosomal complex |
| D | 0006397 | biological_process | mRNA processing |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0008380 | biological_process | RNA splicing |
| D | 0016363 | cellular_component | nuclear matrix |
| D | 0016607 | cellular_component | nuclear speck |
| D | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0048863 | biological_process | stem cell differentiation |
| D | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| D | 0071011 | cellular_component | precatalytic spliceosome |
| D | 1903241 | biological_process | U2-type prespliceosome assembly |
| I | 0000398 | biological_process | mRNA splicing, via spliceosome |
| I | 0003723 | molecular_function | RNA binding |
| I | 0005515 | molecular_function | protein binding |
| I | 0005634 | cellular_component | nucleus |
| I | 0005654 | cellular_component | nucleoplasm |
| I | 0005681 | cellular_component | spliceosomal complex |
| I | 0005684 | cellular_component | U2-type spliceosomal complex |
| I | 0005686 | cellular_component | U2 snRNP |
| I | 0005689 | cellular_component | U12-type spliceosomal complex |
| I | 0006397 | biological_process | mRNA processing |
| I | 0008380 | biological_process | RNA splicing |
| I | 0016607 | cellular_component | nuclear speck |
| I | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| I | 0071011 | cellular_component | precatalytic spliceosome |
| I | 0071013 | cellular_component | catalytic step 2 spliceosome |
| I | 1903241 | biological_process | U2-type prespliceosome assembly |
| K | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| K | 0000398 | biological_process | mRNA splicing, via spliceosome |
| K | 0003676 | molecular_function | nucleic acid binding |
| K | 0003723 | molecular_function | RNA binding |
| K | 0005515 | molecular_function | protein binding |
| K | 0005634 | cellular_component | nucleus |
| K | 0005654 | cellular_component | nucleoplasm |
| K | 0005681 | cellular_component | spliceosomal complex |
| K | 0005684 | cellular_component | U2-type spliceosomal complex |
| K | 0005686 | cellular_component | U2 snRNP |
| K | 0005689 | cellular_component | U12-type spliceosomal complex |
| K | 0006397 | biological_process | mRNA processing |
| K | 0008380 | biological_process | RNA splicing |
| K | 0048026 | biological_process | positive regulation of mRNA splicing, via spliceosome |
| K | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| K | 1903241 | biological_process | U2-type prespliceosome assembly |
| K | 1990935 | molecular_function | splicing factor binding |
| M | 0000245 | biological_process | spliceosomal complex assembly |
| M | 0000389 | biological_process | mRNA 3'-splice site recognition |
| M | 0000398 | biological_process | mRNA splicing, via spliceosome |
| M | 0003676 | molecular_function | nucleic acid binding |
| M | 0003723 | molecular_function | RNA binding |
| M | 0005515 | molecular_function | protein binding |
| M | 0005634 | cellular_component | nucleus |
| M | 0005654 | cellular_component | nucleoplasm |
| M | 0005681 | cellular_component | spliceosomal complex |
| M | 0005684 | cellular_component | U2-type spliceosomal complex |
| M | 0005686 | cellular_component | U2 snRNP |
| M | 0006397 | biological_process | mRNA processing |
| M | 0008270 | molecular_function | zinc ion binding |
| M | 0008380 | biological_process | RNA splicing |
| M | 0010976 | biological_process | positive regulation of neuron projection development |
| M | 0016607 | cellular_component | nuclear speck |
| M | 0046872 | molecular_function | metal ion binding |
| M | 0071004 | cellular_component | U2-type prespliceosome |
| M | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| M | 0071013 | cellular_component | catalytic step 2 spliceosome |
| M | 1903241 | biological_process | U2-type prespliceosome assembly |
| N | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| N | 0000389 | biological_process | mRNA 3'-splice site recognition |
| N | 0000398 | biological_process | mRNA splicing, via spliceosome |
| N | 0003676 | molecular_function | nucleic acid binding |
| N | 0003723 | molecular_function | RNA binding |
| N | 0005515 | molecular_function | protein binding |
| N | 0005634 | cellular_component | nucleus |
| N | 0005654 | cellular_component | nucleoplasm |
| N | 0005681 | cellular_component | spliceosomal complex |
| N | 0005684 | cellular_component | U2-type spliceosomal complex |
| N | 0005686 | cellular_component | U2 snRNP |
| N | 0006397 | biological_process | mRNA processing |
| N | 0008270 | molecular_function | zinc ion binding |
| N | 0008380 | biological_process | RNA splicing |
| N | 0016607 | cellular_component | nuclear speck |
| N | 0046872 | molecular_function | metal ion binding |
| N | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| N | 0071013 | cellular_component | catalytic step 2 spliceosome |
| N | 1903241 | biological_process | U2-type prespliceosome assembly |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH |
| Chain | Residue | Details |
| A | PHE287-HIS293 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | ZN_FING: Matrin-type => ECO:0000255|PROSITE-ProRule:PRU00130 |
| Chain | Residue | Details |
| M | TYR54-ARG84 | |
| D | CYS72 | |
| D | CYS75 | |
| D | CYS85 | |
| I | ARG245 | |
| I | ARG247 | |
| I | ARG515 | |
| D | CYS33 | |
| D | CYS46 | |
| D | CYS49 | |
| D | CYS58 | |
| D | CYS61 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000269|Ref.6 |
| Chain | Residue | Details |
| M | MET1 | |
| A | LYS1171 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q62203 |
| Chain | Residue | Details |
| M | LYS10 | |
| C | CYS677 | |
| C | GLU1205 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| M | SER153 | |
| C | THR235 | |
| C | THR426 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| I | SER307 | |
| I | SER309 | |
| N | SER369 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| I | THR311 | |
| C | LYS554 | |
| C | LYS562 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| I | SER317 | |
| I | SER861 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| I | SER360 | |
| I | SER362 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| I | SER431 | |
| I | SER435 | |
| I | SER436 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT9; alternate => ECO:0000269|PubMed:25737013 |
| Chain | Residue | Details |
| I | ARG508 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| I | THR780 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 9 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| I | LYS10 | |
| I | LYS280 | |
| I | LYS492 | |
| I | LYS543 | |
| I | LYS770 | |
| I | LYS790 | |
| I | LYS843 | |
| I | LYS857 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| I | LYS400 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| I | LYS412 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | THR227 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q99NB9 |
| Chain | Residue | Details |
| C | SER229 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:12105215 |
| Chain | Residue | Details |
| C | THR244 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000305|PubMed:12105215 |
| Chain | Residue | Details |
| C | THR248 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | THR257 | |
| C | THR261 | |
| C | THR278 | |
| C | THR303 | |
| C | THR313 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | THR267 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | THR273 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | SER287 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | THR296 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983 |
| Chain | Residue | Details |
| C | THR299 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER322 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | THR326 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| C | THR328 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER332 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| C | THR341 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| C | SER344 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| C | SER349 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | THR350 | |
| C | THR436 |
| site_id | SWS_FT_FI33 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | THR354 |
| site_id | SWS_FT_FI34 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER400 |
| site_id | SWS_FT_FI35 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by DYRK1A => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | THR434 |
| site_id | SWS_FT_FI36 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | SER488 |
| site_id | SWS_FT_FI37 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| C | LYS214 |
| site_id | SWS_FT_FI38 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| C | LYS430 |
| site_id | SWS_FT_FI39 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| C | LYS413 |
