7OK1
Crystal structure of Pseudomonas aeruginosa LpxA in complex with compound 3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008610 | biological_process | lipid biosynthetic process |
| A | 0008780 | molecular_function | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity |
| A | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0008610 | biological_process | lipid biosynthetic process |
| B | 0008780 | molecular_function | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity |
| B | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0008610 | biological_process | lipid biosynthetic process |
| C | 0008780 | molecular_function | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity |
| C | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| C | 0009245 | biological_process | lipid A biosynthetic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue VFN A 301 |
| Chain | Residue |
| A | LEU112 |
| A | VAL132 |
| A | ASN133 |
| A | SER150 |
| A | GLY151 |
| B | ASP70 |
| B | HIS118 |
| B | ALA138 |
| B | GLN157 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue VFN A 302 |
| Chain | Residue |
| A | ASP70 |
| A | LEU71 |
| A | ALA138 |
| A | GLN157 |
| C | VAL132 |
| C | ASN133 |
| C | SER150 |
| C | GLY151 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 303 |
| Chain | Residue |
| A | ARG89 |
| A | ALA115 |
| A | HOH415 |
| B | PRO69 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 304 |
| Chain | Residue |
| A | GLY168 |
| A | MET169 |
| A | HOH452 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 305 |
| Chain | Residue |
| A | ARG199 |
| B | ARG199 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 306 |
| Chain | Residue |
| A | GLY35 |
| A | LYS54 |
| C | ARG15 |
| C | HOH435 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 307 |
| Chain | Residue |
| C | LYS54 |
| C | HOH420 |
| C | HOH438 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue VFN B 301 |
| Chain | Residue |
| B | LEU112 |
| B | VAL132 |
| B | ASN133 |
| B | SER150 |
| B | GLY151 |
| C | ASP70 |
| C | ALA136 |
| C | ALA138 |
| C | GLN157 |
| C | HOH487 |
Functional Information from PROSITE/UniProt
| site_id | PS00101 |
| Number of Residues | 29 |
| Details | HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IDprAiIdpsArLAadVqVGpwSiVgaeV |
| Chain | Residue | Details |
| A | ILE4-VAL32 |
