7OJY
Crystal structure of Pseudomonas aeruginosa LpxA in complex with compound 6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008610 | biological_process | lipid biosynthetic process |
| A | 0008780 | molecular_function | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008610 | biological_process | lipid biosynthetic process |
| B | 0008780 | molecular_function | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008610 | biological_process | lipid biosynthetic process |
| C | 0008780 | molecular_function | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity |
| C | 0009245 | biological_process | lipid A biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue VGQ A 301 |
| Chain | Residue |
| A | LEU112 |
| A | VAL132 |
| A | ASN133 |
| A | SER150 |
| A | GLY151 |
| A | HOH523 |
| B | HIS118 |
| B | ALA138 |
| B | GLN157 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 302 |
| Chain | Residue |
| A | LYS54 |
| C | HOH417 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 303 |
| Chain | Residue |
| A | MET169 |
| A | HOH465 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 304 |
| Chain | Residue |
| A | ARG89 |
| A | ALA115 |
| A | HOH443 |
| A | HOH561 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 305 |
| Chain | Residue |
| A | ARG199 |
| B | ARG199 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 306 |
| Chain | Residue |
| A | PRO69 |
| A | HIS95 |
| A | GLY120 |
| A | HIS121 |
| A | HOH416 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 307 |
| Chain | Residue |
| A | THR182 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue VGQ B 301 |
| Chain | Residue |
| B | LEU112 |
| B | VAL132 |
| B | ASN133 |
| B | SER150 |
| B | GLY151 |
| B | HOH495 |
| C | HIS121 |
| C | ALA138 |
| C | GLN157 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 302 |
| Chain | Residue |
| B | ARG89 |
| B | ALA115 |
| B | HOH409 |
| B | HOH423 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 303 |
| Chain | Residue |
| B | HIS95 |
| B | GLY120 |
| B | HIS121 |
| B | HOH405 |
| B | HOH560 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 304 |
| Chain | Residue |
| B | ARG89 |
| B | HOH525 |
| C | GLU66 |
| C | ASP67 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 305 |
| Chain | Residue |
| B | GLY168 |
| B | MET169 |
| B | HOH425 |
| site_id | AD4 |
| Number of Residues | 10 |
| Details | binding site for residue VGQ C 301 |
| Chain | Residue |
| A | HIS118 |
| A | ALA138 |
| A | GLN157 |
| C | LEU112 |
| C | VAL132 |
| C | ASN133 |
| C | SER150 |
| C | GLY151 |
| C | MET169 |
| C | HOH499 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue CL C 302 |
| Chain | Residue |
| C | PRO69 |
| C | HIS95 |
| C | HIS121 |
| C | HOH418 |
| C | HOH542 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 303 |
| Chain | Residue |
| A | HOH449 |
| C | GLY35 |
| C | LYS54 |
| C | HOH467 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 304 |
| Chain | Residue |
| C | ARG89 |
| C | ALA115 |
| C | HOH447 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 305 |
| Chain | Residue |
| C | GLY168 |
| C | MET169 |
| C | HOH453 |
Functional Information from PROSITE/UniProt
| site_id | PS00101 |
| Number of Residues | 29 |
| Details | HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IDprAiIdpsArLAadVqVGpwSiVgaeV |
| Chain | Residue | Details |
| A | ILE4-VAL32 |
