7OJ6
Crystal structure of Pseudomonas aeruginosa LpxA in complex with compound 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008610 | biological_process | lipid biosynthetic process |
| A | 0008780 | molecular_function | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity |
| A | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008610 | biological_process | lipid biosynthetic process |
| B | 0008780 | molecular_function | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity |
| B | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008610 | biological_process | lipid biosynthetic process |
| C | 0008780 | molecular_function | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity |
| C | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| C | 0009245 | biological_process | lipid A biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue VFE A 301 |
| Chain | Residue |
| A | LEU112 |
| B | GLN157 |
| B | HOH437 |
| A | VAL132 |
| A | ASN133 |
| A | SER150 |
| A | GLY151 |
| A | HOH413 |
| A | HOH429 |
| A | HOH521 |
| B | ALA138 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 302 |
| Chain | Residue |
| A | ARG199 |
| B | ARG199 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 303 |
| Chain | Residue |
| A | ARG89 |
| A | ALA115 |
| A | HOH454 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 304 |
| Chain | Residue |
| A | MET169 |
| A | HOH590 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 305 |
| Chain | Residue |
| A | HIS164 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 306 |
| Chain | Residue |
| A | THR182 |
| A | ACT312 |
| A | HOH543 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 307 |
| Chain | Residue |
| A | PRO69 |
| A | HIS95 |
| A | HIS121 |
| A | HOH431 |
| A | HOH589 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 308 |
| Chain | Residue |
| A | LYS54 |
| C | HOH467 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 309 |
| Chain | Residue |
| A | ARG102 |
| A | ALA103 |
| A | GLU104 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 310 |
| Chain | Residue |
| A | VAL225 |
| A | GLY255 |
| A | ILE256 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 311 |
| Chain | Residue |
| A | ARG79 |
| A | HOH446 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 312 |
| Chain | Residue |
| A | ASN194 |
| A | CL306 |
| A | HOH500 |
| site_id | AD4 |
| Number of Residues | 11 |
| Details | binding site for residue VFE B 301 |
| Chain | Residue |
| B | LEU112 |
| B | VAL132 |
| B | ASN133 |
| B | SER150 |
| B | GLY151 |
| B | HOH401 |
| B | HOH442 |
| B | HOH448 |
| B | HOH503 |
| C | ALA138 |
| C | GLN157 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 302 |
| Chain | Residue |
| B | THR182 |
| B | HOH445 |
| B | HOH498 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 303 |
| Chain | Residue |
| A | ARG199 |
| B | GLU196 |
| B | ARG200 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 304 |
| Chain | Residue |
| B | GLY168 |
| B | MET169 |
| B | HOH565 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 305 |
| Chain | Residue |
| B | ARG89 |
| B | ALA115 |
| B | HOH423 |
| B | HOH463 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue CL B 306 |
| Chain | Residue |
| B | PRO69 |
| B | HIS95 |
| B | GLY120 |
| B | HIS121 |
| B | HOH434 |
| B | HOH567 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 307 |
| Chain | Residue |
| B | GLY35 |
| B | GLU36 |
| B | LYS54 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 308 |
| Chain | Residue |
| B | HIS164 |
| B | ARG201 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 309 |
| Chain | Residue |
| B | PHE166 |
| B | ASN194 |
| B | GLU196 |
| B | HOH506 |
| site_id | AE4 |
| Number of Residues | 12 |
| Details | binding site for residue VFE C 301 |
| Chain | Residue |
| A | HIS118 |
| A | ALA138 |
| A | GLN157 |
| C | LEU112 |
| C | ILE130 |
| C | VAL132 |
| C | ASN133 |
| C | SER150 |
| C | GLY151 |
| C | HOH405 |
| C | HOH409 |
| C | HOH472 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 302 |
| Chain | Residue |
| A | HOH462 |
| C | LYS54 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 303 |
| Chain | Residue |
| C | ARG89 |
| C | ALA115 |
| C | HOH538 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue CL C 304 |
| Chain | Residue |
| C | HIS121 |
| C | HOH432 |
| C | HOH552 |
| C | PRO69 |
| C | HIS95 |
| C | GLY120 |
| site_id | AE8 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 305 |
| Chain | Residue |
| C | THR182 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 306 |
| Chain | Residue |
| B | ARG89 |
| B | HOH515 |
| C | GLU66 |
| C | ASP67 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue ACT C 307 |
| Chain | Residue |
| C | VAL39 |
| C | GLY41 |
| C | ARG57 |
| C | ILE58 |
Functional Information from PROSITE/UniProt
| site_id | PS00101 |
| Number of Residues | 29 |
| Details | HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IDprAiIdpsArLAadVqVGpwSiVgaeV |
| Chain | Residue | Details |
| A | ILE4-VAL32 |
