Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7OH6

Cryo-EM structure of Drs2p-Cdc50p in the [PS]E2-AlFx state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0005215	molecular_function	transporter activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005768	cellular_component	endosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005794	cellular_component	Golgi apparatus
A	0005802	cellular_component	trans-Golgi network
A	0005886	cellular_component	plasma membrane
A	0006892	biological_process	post-Golgi vesicle-mediated transport
A	0006897	biological_process	endocytosis
A	0008289	molecular_function	lipid binding
A	0010008	cellular_component	endosome membrane
A	0015914	biological_process	phospholipid transport
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0032456	biological_process	endocytic recycling
A	0045332	biological_process	phospholipid translocation
A	0046872	molecular_function	metal ion binding
A	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
A	0090555	molecular_function	phosphatidylethanolamine flippase activity
A	0090556	molecular_function	phosphatidylserine floppase activity
A	0140326	molecular_function	ATPase-coupled intramembrane lipid transporter activity
A	0140331	biological_process	aminophospholipid translocation
A	0140345	molecular_function	phosphatidylcholine flippase activity
A	0140346	molecular_function	phosphatidylserine flippase activity
A	1990530	cellular_component	Cdc50p-Drs2p complex
A	1990531	cellular_component	phospholipid-translocating ATPase complex
C	0005515	molecular_function	protein binding
C	0005768	cellular_component	endosome
C	0005783	cellular_component	endoplasmic reticulum
C	0005794	cellular_component	Golgi apparatus
C	0005802	cellular_component	trans-Golgi network
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006886	biological_process	intracellular protein transport
C	0006897	biological_process	endocytosis
C	0015247	molecular_function	aminophospholipid flippase activity
C	0016020	cellular_component	membrane
C	0031902	cellular_component	late endosome membrane
C	0042147	biological_process	retrograde transport, endosome to Golgi
C	0045332	biological_process	phospholipid translocation
C	0051666	biological_process	actin cortical patch localization
C	0140331	biological_process	aminophospholipid translocation
C	1990530	cellular_component	Cdc50p-Drs2p complex
C	1990531	cellular_component	phospholipid-translocating ATPase complex

Functional Information from PROSITE/UniProt

site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT

Chain	Residue	Details
A	ASP560-THR566

site_id	PS00188
Number of Residues	18
Details	BIOTIN Biotin-requiring enzymes attachment site. GEvLliLeAMKMeteIrA

Chain	Residue	Details
A	GLY1424-ALA1441

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	330
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	718
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Region: {"description":"Involved in phosphatidylserine substrate recognition","evidences":[{"source":"PubMed","id":"23302692","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"source":"PubMed","id":"19411703","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Y2Q0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04191","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P32660","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34023399","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34023399","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OH5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8NB49","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31243363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34023399","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ROI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31243363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34023399","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ROI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31243363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34023399","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ROI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ROJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31243363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34023399","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ROI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31243363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34023399","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ROI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ROJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Site: {"description":"Involved in the release of the transported lipid into the cytosolic leaflet","evidences":[{"source":"UniProtKB","id":"C7EXK4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	261
Details	Region: {"description":"Confers specificity for binding DRS2","evidences":[{"source":"PubMed","id":"22791719","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31243363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31515475","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31243363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31515475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OH6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7OH7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31243363","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)