7OCK

MAT in complex with SAMH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0047625	molecular_function	S-adenosyl-L-methionine lyase activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004478	molecular_function	methionine adenosyltransferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006556	biological_process	S-adenosylmethionine biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0016740	molecular_function	transferase activity
B	0030955	molecular_function	potassium ion binding
B	0033353	biological_process	S-adenosylmethionine cycle
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004478	molecular_function	methionine adenosyltransferase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006556	biological_process	S-adenosylmethionine biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0016740	molecular_function	transferase activity
C	0030955	molecular_function	potassium ion binding
C	0033353	biological_process	S-adenosylmethionine cycle
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0004478	molecular_function	methionine adenosyltransferase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006556	biological_process	S-adenosylmethionine biosynthetic process
D	0006730	biological_process	one-carbon metabolic process
D	0016740	molecular_function	transferase activity
D	0030955	molecular_function	potassium ion binding
D	0033353	biological_process	S-adenosylmethionine cycle
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0004478	molecular_function	methionine adenosyltransferase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006556	biological_process	S-adenosylmethionine biosynthetic process
E	0006730	biological_process	one-carbon metabolic process
E	0016740	molecular_function	transferase activity
E	0030955	molecular_function	potassium ion binding
E	0033353	biological_process	S-adenosylmethionine cycle
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0004478	molecular_function	methionine adenosyltransferase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006556	biological_process	S-adenosylmethionine biosynthetic process
F	0006730	biological_process	one-carbon metabolic process
F	0016740	molecular_function	transferase activity
F	0030955	molecular_function	potassium ion binding
F	0033353	biological_process	S-adenosylmethionine cycle
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0004478	molecular_function	methionine adenosyltransferase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006556	biological_process	S-adenosylmethionine biosynthetic process
G	0006730	biological_process	one-carbon metabolic process
G	0016740	molecular_function	transferase activity
G	0030955	molecular_function	potassium ion binding
G	0033353	biological_process	S-adenosylmethionine cycle
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0004478	molecular_function	methionine adenosyltransferase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006556	biological_process	S-adenosylmethionine biosynthetic process
H	0006730	biological_process	one-carbon metabolic process
H	0016740	molecular_function	transferase activity
H	0030955	molecular_function	potassium ion binding
H	0033353	biological_process	S-adenosylmethionine cycle
H	0042802	molecular_function	identical protein binding
H	0046872	molecular_function	metal ion binding
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0004478	molecular_function	methionine adenosyltransferase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006556	biological_process	S-adenosylmethionine biosynthetic process
I	0006730	biological_process	one-carbon metabolic process
I	0016740	molecular_function	transferase activity
I	0030955	molecular_function	potassium ion binding
I	0033353	biological_process	S-adenosylmethionine cycle
I	0042802	molecular_function	identical protein binding
I	0046872	molecular_function	metal ion binding
J	0016740	molecular_function	transferase activity
J	0016829	molecular_function	lyase activity
J	0047625	molecular_function	S-adenosyl-L-methionine lyase activity
K	0016740	molecular_function	transferase activity
K	0016829	molecular_function	lyase activity
K	0047625	molecular_function	S-adenosyl-L-methionine lyase activity
L	0016740	molecular_function	transferase activity
L	0016829	molecular_function	lyase activity
L	0047625	molecular_function	S-adenosyl-L-methionine lyase activity

Functional Information from PROSITE/UniProt

site_id	PS00376
Number of Residues	11
Details	ADOMET_SYNTHASE_1 S-adenosylmethionine synthase signature 1. GAGDQGlmfGY

Chain	Residue	Details
B	GLY115-TYR125

---

site_id	PS00377
Number of Residues	9
Details	ADOMET_SYNTHASE_2 S-adenosylmethionine synthase signature 2. GGGAFSgKD

Chain	Residue	Details
B	GLY258-ASP266

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Region: {"description":"Flexible loop","evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14967023","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	64
Details	Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14967023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1P7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RG9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14967023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1P7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RG9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14967023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7629147","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1MXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RG9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14967023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1P7L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---