7O4V
Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with oxidized nicotinamide adenine dinucleotide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0003857 | molecular_function | 3-hydroxyacyl-CoA dehydrogenase activity |
A | 0004300 | molecular_function | enoyl-CoA hydratase activity |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006631 | biological_process | fatty acid metabolic process |
A | 0006635 | biological_process | fatty acid beta-oxidation |
A | 0009056 | biological_process | catabolic process |
A | 0009274 | cellular_component | peptidoglycan-based cell wall |
A | 0016042 | biological_process | lipid catabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016509 | molecular_function | long-chain-3-hydroxyacyl-CoA dehydrogenase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0016829 | molecular_function | lyase activity |
A | 0070403 | molecular_function | NAD+ binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0003857 | molecular_function | 3-hydroxyacyl-CoA dehydrogenase activity |
B | 0004300 | molecular_function | enoyl-CoA hydratase activity |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0006631 | biological_process | fatty acid metabolic process |
B | 0006635 | biological_process | fatty acid beta-oxidation |
B | 0009056 | biological_process | catabolic process |
B | 0009274 | cellular_component | peptidoglycan-based cell wall |
B | 0016042 | biological_process | lipid catabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016509 | molecular_function | long-chain-3-hydroxyacyl-CoA dehydrogenase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0016829 | molecular_function | lyase activity |
B | 0070403 | molecular_function | NAD+ binding |
C | 0005886 | cellular_component | plasma membrane |
C | 0009274 | cellular_component | peptidoglycan-based cell wall |
C | 0016746 | molecular_function | acyltransferase activity |
C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
D | 0005886 | cellular_component | plasma membrane |
D | 0009274 | cellular_component | peptidoglycan-based cell wall |
D | 0016746 | molecular_function | acyltransferase activity |
D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | binding site for residue NAD B 801 |
Chain | Residue |
B | ALA333 |
B | GLU414 |
B | LEU418 |
B | LYS419 |
B | VAL422 |
B | ASN439 |
B | SER441 |
B | HIS462 |
B | GLY334 |
B | MET335 |
B | MET336 |
B | ASP355 |
B | VAL356 |
B | ALA411 |
B | VAL412 |
B | PHE413 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue SO4 B 802 |
Chain | Residue |
B | PRO259 |
B | GLY293 |
B | GLN294 |
B | VAL295 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue SO4 B 803 |
Chain | Residue |
B | HIS-7 |
B | HIS-6 |
B | HIS-8 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue SO4 B 804 |
Chain | Residue |
B | SER658 |
B | THR659 |
B | ALA660 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue SO4 B 805 |
Chain | Residue |
B | GLY25 |
B | SER26 |
B | THR27 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue SO4 D 501 |
Chain | Residue |
D | THR317 |
D | ARG382 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue SO4 D 502 |
Chain | Residue |
A | VAL274 |
A | ASP275 |
D | HIS24 |
site_id | AC8 |
Number of Residues | 3 |
Details | binding site for residue SO4 D 503 |
Chain | Residue |
D | ASN380 |
D | ARG382 |
D | ARG402 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue SO4 D 504 |
Chain | Residue |
D | SER163 |
D | ARG164 |
D | ASN249 |
site_id | AD1 |
Number of Residues | 3 |
Details | binding site for residue SO4 D 505 |
Chain | Residue |
B | PRO631 |
B | LEU632 |
D | HIS243 |
site_id | AD2 |
Number of Residues | 2 |
Details | binding site for residue SO4 D 506 |
Chain | Residue |
D | ARG195 |
D | LEU201 |
site_id | AD3 |
Number of Residues | 2 |
Details | binding site for residue SO4 D 507 |
Chain | Residue |
D | PRO193 |
D | ARG195 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue SO4 D 508 |
Chain | Residue |
D | LYS177 |
D | ASP345 |
D | GLU346 |
site_id | AD5 |
Number of Residues | 2 |
Details | binding site for residue SO4 C 501 |
Chain | Residue |
C | ARG382 |
C | ARG382 |
site_id | AD6 |
Number of Residues | 3 |
Details | binding site for residue SO4 C 502 |
Chain | Residue |
C | ARG382 |
C | ARG383 |
C | ARG402 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue SO4 C 503 |
Chain | Residue |
B | GLN273 |
B | VAL274 |
B | ASP275 |
C | HIS24 |
site_id | AD8 |
Number of Residues | 2 |
Details | binding site for residue SO4 C 504 |
Chain | Residue |
C | PRO193 |
C | ARG195 |
site_id | AD9 |
Number of Residues | 3 |
Details | binding site for residue SO4 C 505 |
Chain | Residue |
C | SER163 |
C | ARG164 |
C | ASN249 |
site_id | AE1 |
Number of Residues | 2 |
Details | binding site for residue SO4 C 506 |
Chain | Residue |
C | ARG195 |
C | LEU201 |
site_id | AE2 |
Number of Residues | 3 |
Details | binding site for residue SO4 C 507 |
Chain | Residue |
C | LYS177 |
C | ASP345 |
C | GLU346 |
site_id | AE3 |
Number of Residues | 2 |
Details | binding site for residue SO4 C 508 |
Chain | Residue |
C | THR317 |
C | VAL318 |
site_id | AE4 |
Number of Residues | 16 |
Details | binding site for residue NAD A 801 |
Chain | Residue |
A | ALA333 |
A | GLY334 |
A | MET335 |
A | MET336 |
A | ASP355 |
A | VAL356 |
A | ALA411 |
A | VAL412 |
A | GLU414 |
A | LEU418 |
A | LYS419 |
A | VAL422 |
A | ASN439 |
A | THR440 |
A | SER441 |
A | HIS462 |
site_id | AE5 |
Number of Residues | 4 |
Details | binding site for residue SO4 A 802 |
Chain | Residue |
A | PRO259 |
A | GLY293 |
A | GLN294 |
A | VAL295 |
site_id | AE6 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 803 |
Chain | Residue |
A | PRO631 |
A | LEU632 |
C | HIS243 |
site_id | AE7 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 804 |
Chain | Residue |
A | ARG702 |
A | LEU719 |
A | SER720 |
site_id | AE8 |
Number of Residues | 2 |
Details | binding site for residue SO4 A 805 |
Chain | Residue |
A | ARG598 |
A | ARG612 |
site_id | AE9 |
Number of Residues | 4 |
Details | binding site for residue SO4 A 806 |
Chain | Residue |
A | HIS-8 |
A | HIS-6 |
A | HIS-9 |
A | HIS-7 |
Functional Information from PROSITE/UniProt
site_id | PS00098 |
Number of Residues | 19 |
Details | THIOLASE_1 Thiolases acyl-enzyme intermediate signature. LNRfCASGLeAVntaaqkV |
Chain | Residue | Details |
D | LEU88-VAL106 |
site_id | PS00099 |
Number of Residues | 14 |
Details | THIOLASE_3 Thiolases active site. ALITLCIGgGmGvA |
Chain | Residue | Details |
D | ALA384-ALA397 |
site_id | PS00737 |
Number of Residues | 17 |
Details | THIOLASE_2 Thiolases signature 2. NvnGGaIAmGHPlGaTG |
Chain | Residue | Details |
D | ASN349-GLY365 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Acyl-thioester intermediate => ECO:0000250 |
Chain | Residue | Details |
D | CYS92 | |
C | CYS92 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10020 |
Chain | Residue | Details |
D | HIS359 | |
D | CYS389 | |
C | HIS359 | |
C | CYS389 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | CROSSLNK: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) => ECO:0000269|PubMed:20066036 |
Chain | Residue | Details |
D | LYS189 | |
C | LYS189 |