7O4U

Structure of the alpha subunit of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with oxidized nicotinamide adenine dinucleotide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
A	0004300	molecular_function	enoyl-CoA hydratase activity
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006631	biological_process	fatty acid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016042	biological_process	lipid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016509	molecular_function	long-chain-3-hydroxyacyl-CoA dehydrogenase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0016829	molecular_function	lyase activity
A	0044248	biological_process	cellular catabolic process
A	0070403	molecular_function	NAD+ binding
B	0000166	molecular_function	nucleotide binding
B	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
B	0004300	molecular_function	enoyl-CoA hydratase activity
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006631	biological_process	fatty acid metabolic process
B	0006635	biological_process	fatty acid beta-oxidation
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0016042	biological_process	lipid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016509	molecular_function	long-chain-3-hydroxyacyl-CoA dehydrogenase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0016829	molecular_function	lyase activity
B	0044248	biological_process	cellular catabolic process
B	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue NAD A 801

Chain	Residue
A	GLY332
A	GLU414
A	LYS419
A	ASN439
A	HIS462
A	SER465
A	ALA333
A	MET335
A	MET336
A	ASP355
A	VAL356
A	ALA411
A	VAL412
A	PHE413

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site_id	AC2
Number of Residues	15
Details	binding site for residue NAD B 801

Chain	Residue
B	GLY332
B	GLY334
B	MET335
B	MET336
B	ASP355
B	VAL356
B	ALA411
B	VAL412
B	PHE413
B	GLU414
B	LYS419
B	VAL422
B	ASN439
B	SER441
B	HIS462

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