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7O4Q

Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in space group C2221 (unliganded)

Functional Information from GO Data
ChainGOidnamespacecontents
B0000166molecular_functionnucleotide binding
B0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
B0004300molecular_functionenoyl-CoA hydratase activity
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006631biological_processfatty acid metabolic process
B0006635biological_processfatty acid beta-oxidation
B0009274cellular_componentpeptidoglycan-based cell wall
B0016042biological_processlipid catabolic process
B0016491molecular_functionoxidoreductase activity
B0016509molecular_functionlong-chain-3-hydroxyacyl-CoA dehydrogenase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0016829molecular_functionlyase activity
B0070403molecular_functionNAD+ binding
C0003985molecular_functionacetyl-CoA C-acetyltransferase activity
C0005886cellular_componentplasma membrane
C0009274cellular_componentpeptidoglycan-based cell wall
C0016746molecular_functionacyltransferase activity
C0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue GOL B 901
ChainResidue
BGLU414
BTHR442
BLEU559
BLYS562
BILE563
BHOH1093
BHOH1113

site_idAC2
Number of Residues2
Detailsbinding site for residue GOL B 902
ChainResidue
BLYS365
BPRO395

site_idAC3
Number of Residues5
Detailsbinding site for residue SO4 B 903
ChainResidue
BGLY293
BGLN294
BVAL295
BHOH1072
BHOH1116

site_idAC4
Number of Residues3
Detailsbinding site for residue SO4 B 904
ChainResidue
BVAL274
BASP275
CHIS24

site_idAC5
Number of Residues4
Detailsbinding site for residue SO4 B 905
ChainResidue
BPRO631
BLEU632
BHOH1140
CHIS243

site_idAC6
Number of Residues3
Detailsbinding site for residue SO4 B 906
ChainResidue
BTYR607
BALA608
BGLY610

site_idAC7
Number of Residues3
Detailsbinding site for residue SO4 B 907
ChainResidue
BSER658
BTHR659
BALA660

site_idAC8
Number of Residues4
Detailsbinding site for residue SO4 B 908
ChainResidue
BLYS133
BARG702
BLEU719
BSER720

site_idAC9
Number of Residues3
Detailsbinding site for residue SO4 B 909
ChainResidue
BARG598
BLYS611
BARG612

site_idAD1
Number of Residues3
Detailsbinding site for residue SO4 B 910
ChainResidue
BPRO220
BLYS223
BHOH1014

site_idAD2
Number of Residues3
Detailsbinding site for residue SO4 B 911
ChainResidue
BLYS133
BLYS177
BARG385

site_idAD3
Number of Residues4
Detailsbinding site for residue SO4 B 912
ChainResidue
BSER357
BLEU358
BGLU359
BHOH1082

site_idAD4
Number of Residues5
Detailsbinding site for residue SO4 B 913
ChainResidue
BASP468
BLYS469
BPRO471
BGLY497
BLYS498

site_idAD5
Number of Residues6
Detailsbinding site for residue GOL C 701
ChainResidue
CILE36
CLEU39
CARG40
CGLU48
CMET79
CMET268

site_idAD6
Number of Residues4
Detailsbinding site for residue GOL C 702
ChainResidue
CGLY131
CGLY132
CMET134
CGLY135

site_idAD7
Number of Residues2
Detailsbinding site for residue GOL C 703
ChainResidue
CGLU246
CLYS247

site_idAD8
Number of Residues8
Detailsbinding site for residue GOL C 704
ChainResidue
BLYS251
CLEU231
CGLY232
CGLY233
CPHE234
CASP235
CASP236
CHOH805

site_idAD9
Number of Residues4
Detailsbinding site for residue SO4 C 705
ChainResidue
CSER163
CARG164
CASN249
CHOH847

site_idAE1
Number of Residues4
Detailsbinding site for residue SO4 C 706
ChainResidue
CARG173
CLYS177
CASP345
CGLU346

site_idAE2
Number of Residues3
Detailsbinding site for residue SO4 C 707
ChainResidue
CARG195
CLEU201
CHOH803

site_idAE3
Number of Residues4
Detailsbinding site for residue SO4 C 708
ChainResidue
CPRO193
CARG195
CSO4709
CHOH884

site_idAE4
Number of Residues6
Detailsbinding site for residue SO4 C 709
ChainResidue
CGLU38
CARG42
CALA188
CVAL191
CPRO193
CSO4708

site_idAE5
Number of Residues2
Detailsbinding site for residue SO4 C 710
ChainResidue
CARG382
CARG402

site_idAE6
Number of Residues2
Detailsbinding site for residue SO4 C 711
ChainResidue
CGLU180
CARG382

site_idAE7
Number of Residues3
Detailsbinding site for residue SO4 C 712
ChainResidue
CARG285
CVAL287
CALA314

site_idAE8
Number of Residues3
Detailsbinding site for residue SO4 C 713
ChainResidue
CHOH802
CTHR317
CVAL318

site_idAE9
Number of Residues2
Detailsbinding site for residue SO4 C 714
ChainResidue
CTHR304
CARG308

Functional Information from PROSITE/UniProt
site_idPS00098
Number of Residues19
DetailsTHIOLASE_1 Thiolases acyl-enzyme intermediate signature. LNRfCASGLeAVntaaqkV
ChainResidueDetails
CLEU88-VAL106

site_idPS00099
Number of Residues14
DetailsTHIOLASE_3 Thiolases active site. ALITLCIGgGmGvA
ChainResidueDetails
CALA384-ALA397

site_idPS00737
Number of Residues17
DetailsTHIOLASE_2 Thiolases signature 2. NvnGGaIAmGHPlGaTG
ChainResidueDetails
CASN349-GLY365

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Acyl-thioester intermediate => ECO:0000250
ChainResidueDetails
CCYS92

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10020
ChainResidueDetails
CHIS359
CCYS389

site_idSWS_FT_FI3
Number of Residues2
DetailsCROSSLNK: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) => ECO:0000269|PubMed:20066036
ChainResidueDetails
CLYS189

227344

PDB entries from 2024-11-13

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