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7O4L

Yeast TFIIH in the expanded state within the pre-initiation complex

Functional Information from GO Data
ChainGOidnamespacecontents
00000019biological_processregulation of mitotic recombination
00000112cellular_componentnucleotide-excision repair factor 3 complex
00000439cellular_componenttranscription factor TFIIH core complex
00003676molecular_functionnucleic acid binding
00003677molecular_functionDNA binding
00003678molecular_functionDNA helicase activity
00003684molecular_functiondamaged DNA binding
00003689molecular_functionDNA clamp loader activity
00004386molecular_functionhelicase activity
00005515molecular_functionprotein binding
00005524molecular_functionATP binding
00005634cellular_componentnucleus
00005675cellular_componenttranscription factor TFIIH holo complex
00005829cellular_componentcytosol
00006139biological_processnucleobase-containing compound metabolic process
00006281biological_processDNA repair
00006289biological_processnucleotide-excision repair
00006338biological_processchromatin remodeling
00006366biological_processtranscription by RNA polymerase II
00006367biological_processtranscription initiation at RNA polymerase II promoter
00006974biological_processDNA damage response
00008094molecular_functionATP-dependent activity, acting on DNA
00009378molecular_functionfour-way junction helicase activity
00016787molecular_functionhydrolase activity
00016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
00016853molecular_functionisomerase activity
00016887molecular_functionATP hydrolysis activity
00032508biological_processDNA duplex unwinding
00036121molecular_functiondouble-stranded DNA helicase activity
00043139molecular_function5'-3' DNA helicase activity
00045951biological_processpositive regulation of mitotic recombination
00046872molecular_functionmetal ion binding
00051539molecular_function4 iron, 4 sulfur cluster binding
00061749molecular_functionforked DNA-dependent helicase activity
00061775molecular_functioncohesin loader activity
00140584molecular_functionchromatin extrusion motor activity
00140588biological_processchromatin looping
00140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
00140849molecular_functionATP-dependent H2AZ histone chaperone activity
01990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
10000112cellular_componentnucleotide-excision repair factor 3 complex
10000439cellular_componenttranscription factor TFIIH core complex
10005515molecular_functionprotein binding
10005634cellular_componentnucleus
10005675cellular_componenttranscription factor TFIIH holo complex
10005829cellular_componentcytosol
10006281biological_processDNA repair
10006289biological_processnucleotide-excision repair
10006351biological_processDNA-templated transcription
10006360biological_processtranscription by RNA polymerase I
10006366biological_processtranscription by RNA polymerase II
10006367biological_processtranscription initiation at RNA polymerase II promoter
10010314molecular_functionphosphatidylinositol-5-phosphate binding
10032266molecular_functionphosphatidylinositol-3-phosphate binding
20000112cellular_componentnucleotide-excision repair factor 3 complex
20000439cellular_componenttranscription factor TFIIH core complex
20001671molecular_functionATPase activator activity
20003690molecular_functiondouble-stranded DNA binding
20005515molecular_functionprotein binding
20005634cellular_componentnucleus
20005675cellular_componenttranscription factor TFIIH holo complex
20006281biological_processDNA repair
20006289biological_processnucleotide-excision repair
20006366biological_processtranscription by RNA polymerase II
20006367biological_processtranscription initiation at RNA polymerase II promoter
30000993molecular_functionRNA polymerase II complex binding
30005634cellular_componentnucleus
30005675cellular_componenttranscription factor TFIIH holo complex
30006281biological_processDNA repair
30006289biological_processnucleotide-excision repair
30006357biological_processregulation of transcription by RNA polymerase II
30006366biological_processtranscription by RNA polymerase II
30006367biological_processtranscription initiation at RNA polymerase II promoter
30008270molecular_functionzinc ion binding
30045737biological_processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
30046872molecular_functionmetal ion binding
30061575molecular_functioncyclin-dependent protein serine/threonine kinase activator activity
30070985cellular_componenttranscription factor TFIIK complex
40000112cellular_componentnucleotide-excision repair factor 3 complex
40000439cellular_componenttranscription factor TFIIH core complex
40005634cellular_componentnucleus
40005675cellular_componenttranscription factor TFIIH holo complex
40006281biological_processDNA repair
40006289biological_processnucleotide-excision repair
40006355biological_processregulation of DNA-templated transcription
40006366biological_processtranscription by RNA polymerase II
40006367biological_processtranscription initiation at RNA polymerase II promoter
40008270molecular_functionzinc ion binding
40016251molecular_functionRNA polymerase II general transcription initiation factor activity
40046872molecular_functionmetal ion binding
50000439cellular_componenttranscription factor TFIIH core complex
50000993molecular_functionRNA polymerase II complex binding
50005515molecular_functionprotein binding
50005634cellular_componentnucleus
50005675cellular_componenttranscription factor TFIIH holo complex
50005829cellular_componentcytosol
50006281biological_processDNA repair
50006289biological_processnucleotide-excision repair
50006294biological_processnucleotide-excision repair, preincision complex assembly
50006366biological_processtranscription by RNA polymerase II
50006367biological_processtranscription initiation at RNA polymerase II promoter
60000112cellular_componentnucleotide-excision repair factor 3 complex
60000439cellular_componenttranscription factor TFIIH core complex
60005634cellular_componentnucleus
60005675cellular_componenttranscription factor TFIIH holo complex
60006281biological_processDNA repair
60006289biological_processnucleotide-excision repair
60006351biological_processDNA-templated transcription
60006357biological_processregulation of transcription by RNA polymerase II
60006366biological_processtranscription by RNA polymerase II
60006367biological_processtranscription initiation at RNA polymerase II promoter
60008270molecular_functionzinc ion binding
60046872molecular_functionmetal ion binding
60061630molecular_functionubiquitin protein ligase activity
70000019biological_processregulation of mitotic recombination
70000112cellular_componentnucleotide-excision repair factor 3 complex
70000439cellular_componenttranscription factor TFIIH core complex
70001111biological_processRNA polymerase II promoter clearance
70001113biological_processtranscription open complex formation at RNA polymerase II promoter
70001174biological_processtranscriptional start site selection at RNA polymerase II promoter
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003689molecular_functionDNA clamp loader activity
70004386molecular_functionhelicase activity
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70005675cellular_componenttranscription factor TFIIH holo complex
70005829cellular_componentcytosol
70006281biological_processDNA repair
70006289biological_processnucleotide-excision repair
70006338biological_processchromatin remodeling
70006366biological_processtranscription by RNA polymerase II
70006367biological_processtranscription initiation at RNA polymerase II promoter
70009378molecular_functionfour-way junction helicase activity
70015616molecular_functionDNA translocase activity
70016787molecular_functionhydrolase activity
70016853molecular_functionisomerase activity
70016887molecular_functionATP hydrolysis activity
70016973biological_processpoly(A)+ mRNA export from nucleus
70032508biological_processDNA duplex unwinding
70036121molecular_functiondouble-stranded DNA helicase activity
70043138molecular_function3'-5' DNA helicase activity
70061749molecular_functionforked DNA-dependent helicase activity
70061775molecular_functioncohesin loader activity
70097550cellular_componenttranscription preinitiation complex
70140584molecular_functionchromatin extrusion motor activity
70140588biological_processchromatin looping
70140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
70140849molecular_functionATP-dependent H2AZ histone chaperone activity
71990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
A0000428cellular_componentDNA-directed RNA polymerase complex
A0001054molecular_functionRNA polymerase I activity
A0001055molecular_functionRNA polymerase II activity
A0001056molecular_functionRNA polymerase III activity
A0001057molecular_functionRNA polymerase IV activity
A0001058molecular_functionRNA polymerase V activity
A0001059biological_processtranscription by RNA polymerase IV
A0001060biological_processtranscription by RNA polymerase V
A0001065molecular_functionmitochondrial single subunit type RNA polymerase activity
A0001066molecular_functionplastid single subunit type RNA polymerase activity
A0001172biological_processRNA-templated transcription
A0003677molecular_functionDNA binding
A0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005665cellular_componentRNA polymerase II, core complex
A0005739cellular_componentmitochondrion
A0006351biological_processDNA-templated transcription
A0006360biological_processtranscription by RNA polymerase I
A0006366biological_processtranscription by RNA polymerase II
A0006367biological_processtranscription initiation at RNA polymerase II promoter
A0006368biological_processtranscription elongation by RNA polymerase II
A0006383biological_processtranscription by RNA polymerase III
A0006390biological_processmitochondrial transcription
A0008270molecular_functionzinc ion binding
A0010494cellular_componentcytoplasmic stress granule
A0016779molecular_functionnucleotidyltransferase activity
A0019985biological_processtranslesion synthesis
A0034062molecular_function5'-3' RNA polymerase activity
A0042793biological_processplastid transcription
A0046872molecular_functionmetal ion binding
B0000428cellular_componentDNA-directed RNA polymerase complex
B0001054molecular_functionRNA polymerase I activity
B0001055molecular_functionRNA polymerase II activity
B0001056molecular_functionRNA polymerase III activity
B0001057molecular_functionRNA polymerase IV activity
B0001058molecular_functionRNA polymerase V activity
B0001059biological_processtranscription by RNA polymerase IV
B0001060biological_processtranscription by RNA polymerase V
B0001065molecular_functionmitochondrial single subunit type RNA polymerase activity
B0001066molecular_functionplastid single subunit type RNA polymerase activity
B0001172biological_processRNA-templated transcription
B0003677molecular_functionDNA binding
B0003729molecular_functionmRNA binding
B0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005665cellular_componentRNA polymerase II, core complex
B0005739cellular_componentmitochondrion
B0006351biological_processDNA-templated transcription
B0006360biological_processtranscription by RNA polymerase I
B0006366biological_processtranscription by RNA polymerase II
B0006367biological_processtranscription initiation at RNA polymerase II promoter
B0006368biological_processtranscription elongation by RNA polymerase II
B0006383biological_processtranscription by RNA polymerase III
B0006390biological_processmitochondrial transcription
B0008270molecular_functionzinc ion binding
B0010494cellular_componentcytoplasmic stress granule
B0016779molecular_functionnucleotidyltransferase activity
B0032549molecular_functionribonucleoside binding
B0034062molecular_function5'-3' RNA polymerase activity
B0042793biological_processplastid transcription
B0046872molecular_functionmetal ion binding
D0000166molecular_functionnucleotide binding
D0000288biological_processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
D0000428cellular_componentDNA-directed RNA polymerase complex
D0000932cellular_componentP-body
D0001172biological_processRNA-templated transcription
D0003697molecular_functionsingle-stranded DNA binding
D0003727molecular_functionsingle-stranded RNA binding
D0003968molecular_functionRNA-dependent RNA polymerase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005665cellular_componentRNA polymerase II, core complex
D0005737cellular_componentcytoplasm
D0006352biological_processDNA-templated transcription initiation
D0006366biological_processtranscription by RNA polymerase II
D0006367biological_processtranscription initiation at RNA polymerase II promoter
D0006368biological_processtranscription elongation by RNA polymerase II
D0006397biological_processmRNA processing
D0030880cellular_componentRNA polymerase complex
D0031369molecular_functiontranslation initiation factor binding
D0044237biological_processcellular metabolic process
D0045948biological_processpositive regulation of translational initiation
D1990328cellular_componentRPB4-RPB7 complex
F0000428cellular_componentDNA-directed RNA polymerase complex
F0001054molecular_functionRNA polymerase I activity
F0001055molecular_functionRNA polymerase II activity
F0001056molecular_functionRNA polymerase III activity
F0001172biological_processRNA-templated transcription
F0003677molecular_functionDNA binding
F0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
F0003968molecular_functionRNA-dependent RNA polymerase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005665cellular_componentRNA polymerase II, core complex
F0005666cellular_componentRNA polymerase III complex
F0005736cellular_componentRNA polymerase I complex
F0005737cellular_componentcytoplasm
F0006351biological_processDNA-templated transcription
F0006360biological_processtranscription by RNA polymerase I
F0006361biological_processtranscription initiation at RNA polymerase I promoter
F0006362biological_processtranscription elongation by RNA polymerase I
F0006363biological_processtermination of RNA polymerase I transcription
F0006366biological_processtranscription by RNA polymerase II
F0006367biological_processtranscription initiation at RNA polymerase II promoter
F0006368biological_processtranscription elongation by RNA polymerase II
F0006383biological_processtranscription by RNA polymerase III
F0006384biological_processtranscription initiation at RNA polymerase III promoter
F0006386biological_processtermination of RNA polymerase III transcription
F0042254biological_processribosome biogenesis
F0042790biological_processnucleolar large rRNA transcription by RNA polymerase I
F0042797biological_processtRNA transcription by RNA polymerase III
G0000288biological_processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
G0000428cellular_componentDNA-directed RNA polymerase complex
G0000932cellular_componentP-body
G0000956biological_processnuclear-transcribed mRNA catabolic process
G0001172biological_processRNA-templated transcription
G0003676molecular_functionnucleic acid binding
G0003697molecular_functionsingle-stranded DNA binding
G0003727molecular_functionsingle-stranded RNA binding
G0003968molecular_functionRNA-dependent RNA polymerase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005665cellular_componentRNA polymerase II, core complex
G0005737cellular_componentcytoplasm
G0006351biological_processDNA-templated transcription
G0006352biological_processDNA-templated transcription initiation
G0006366biological_processtranscription by RNA polymerase II
G0006367biological_processtranscription initiation at RNA polymerase II promoter
G0006368biological_processtranscription elongation by RNA polymerase II
G0031369molecular_functiontranslation initiation factor binding
G0045948biological_processpositive regulation of translational initiation
G0055029cellular_componentnuclear DNA-directed RNA polymerase complex
G0060213biological_processpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
G1990328cellular_componentRPB4-RPB7 complex
W0000993molecular_functionRNA polymerase II complex binding
W0001097molecular_functionTFIIH-class transcription factor complex binding
W0001113biological_processtranscription open complex formation at RNA polymerase II promoter
W0003697molecular_functionsingle-stranded DNA binding
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005673cellular_componenttranscription factor TFIIE complex
W0005739cellular_componentmitochondrion
W0006366biological_processtranscription by RNA polymerase II
W0006367biological_processtranscription initiation at RNA polymerase II promoter
W0008270molecular_functionzinc ion binding
W0046872molecular_functionmetal ion binding
W0097550cellular_componenttranscription preinitiation complex
X0000993molecular_functionRNA polymerase II complex binding
X0001097molecular_functionTFIIH-class transcription factor complex binding
X0003677molecular_functionDNA binding
X0003697molecular_functionsingle-stranded DNA binding
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005673cellular_componenttranscription factor TFIIE complex
X0006366biological_processtranscription by RNA polymerase II
X0006367biological_processtranscription initiation at RNA polymerase II promoter
X0097550cellular_componenttranscription preinitiation complex
Functional Information from PROSITE/UniProt
site_idPS00014
Number of Residues4
DetailsER_TARGET Endoplasmic reticulum targeting sequence. SEEL
ChainResidueDetails
3SER318-LEU321

site_idPS00028
Number of Residues21
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Ced..CkqeFcvdcdvfiHeil..H
ChainResidueDetails
6CYS429-HIS449

site_idPS00115
Number of Residues7
DetailsRNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA
ChainResidueDetails
ATYR1549-ALA1555
ATYR1612-SER1618
ATYR1619-SER1625
ATYR1626-SER1632
ATYR1633-SER1639
ATYR1640-SER1646
ATYR1647-SER1653
ATYR1654-ALA1660
ATYR1661-SER1667
ATYR1668-SER1674
ATYR1675-SER1681
ATYR1556-SER1562
ATYR1682-SER1688
ATYR1689-ASN1695
ATYR1696-SER1702
ATYR1563-SER1569
ATYR1570-SER1576
ATYR1577-SER1583
ATYR1584-SER1590
ATYR1591-SER1597
ATYR1598-SER1604
ATYR1605-SER1611

site_idPS00387
Number of Residues7
DetailsPPASE Inorganic pyrophosphatase signature. DDDEMDI
ChainResidueDetails
WASP471-ILE477

site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CyHrICesCV
ChainResidueDetails
3CYS34-VAL43

site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. SiVIFDEAHN
ChainResidueDetails
0SER230-ASN239

site_idPS01111
Number of Residues15
DetailsRNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARiLGtRAlQ
ChainResidueDetails
FTHR86-GLN100

site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT
ChainResidueDetails
BGLY977-THR989

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues74
DetailsDNA_BIND: TFIIE beta => ECO:0000255|PROSITE-ProRule:PRU00682
ChainResidueDetails
XGLN113-HIS187
AASP483
AASP485
ACYS70
ACYS77
AHIS80
ACYS107
ACYS110
ACYS148
ACYS167
AASP481

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358
ChainResidueDetails
XSER52
DTHR92
BCYS1166
BCYS1182
BCYS1185

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198
ChainResidueDetails
XSER97
ALYS1350

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956
ChainResidueDetails
XSER106

Catalytic Information from CSA
site_idMCSA1
Number of Residues1
DetailsM-CSA 788
ChainResidueDetails
BASP837metal ligand
AASP483metal ligand
AASP485metal ligand
AHIS1085proton acceptor, proton donor

227344

PDB entries from 2024-11-13

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