Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7O4H

The structure of the native CNGA1/CNGB1 CNG channel from retinal rods

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001750	cellular_component	photoreceptor outer segment
A	0005216	molecular_function	monoatomic ion channel activity
A	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
A	0005222	molecular_function	intracellularly cAMP-activated cation channel activity
A	0005223	molecular_function	intracellularly cGMP-activated cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0006814	biological_process	sodium ion transport
A	0006816	biological_process	calcium ion transport
A	0007601	biological_process	visual perception
A	0007606	biological_process	sensory perception of chemical stimulus
A	0016020	cellular_component	membrane
A	0017071	cellular_component	intracellular cyclic nucleotide activated cation channel complex
A	0030552	molecular_function	cAMP binding
A	0030553	molecular_function	cGMP binding
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0120200	cellular_component	rod photoreceptor outer segment
A	1902495	cellular_component	transmembrane transporter complex
B	0000166	molecular_function	nucleotide binding
B	0001750	cellular_component	photoreceptor outer segment
B	0005216	molecular_function	monoatomic ion channel activity
B	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
B	0005222	molecular_function	intracellularly cAMP-activated cation channel activity
B	0005223	molecular_function	intracellularly cGMP-activated cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0006814	biological_process	sodium ion transport
B	0006816	biological_process	calcium ion transport
B	0007601	biological_process	visual perception
B	0007606	biological_process	sensory perception of chemical stimulus
B	0016020	cellular_component	membrane
B	0017071	cellular_component	intracellular cyclic nucleotide activated cation channel complex
B	0030552	molecular_function	cAMP binding
B	0030553	molecular_function	cGMP binding
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
B	0120200	cellular_component	rod photoreceptor outer segment
B	1902495	cellular_component	transmembrane transporter complex
C	0000166	molecular_function	nucleotide binding
C	0001750	cellular_component	photoreceptor outer segment
C	0005216	molecular_function	monoatomic ion channel activity
C	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
C	0005222	molecular_function	intracellularly cAMP-activated cation channel activity
C	0005223	molecular_function	intracellularly cGMP-activated cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006812	biological_process	monoatomic cation transport
C	0006814	biological_process	sodium ion transport
C	0006816	biological_process	calcium ion transport
C	0007601	biological_process	visual perception
C	0007606	biological_process	sensory perception of chemical stimulus
C	0016020	cellular_component	membrane
C	0017071	cellular_component	intracellular cyclic nucleotide activated cation channel complex
C	0030552	molecular_function	cAMP binding
C	0030553	molecular_function	cGMP binding
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0098655	biological_process	monoatomic cation transmembrane transport
C	0120200	cellular_component	rod photoreceptor outer segment
C	1902495	cellular_component	transmembrane transporter complex
D	0000166	molecular_function	nucleotide binding
D	0001750	cellular_component	photoreceptor outer segment
D	0001895	biological_process	retina homeostasis
D	0005216	molecular_function	monoatomic ion channel activity
D	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
D	0005222	molecular_function	intracellularly cAMP-activated cation channel activity
D	0005223	molecular_function	intracellularly cGMP-activated cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0006814	biological_process	sodium ion transport
D	0006816	biological_process	calcium ion transport
D	0007601	biological_process	visual perception
D	0007608	biological_process	sensory perception of smell
D	0016020	cellular_component	membrane
D	0017071	cellular_component	intracellular cyclic nucleotide activated cation channel complex
D	0030552	molecular_function	cAMP binding
D	0030553	molecular_function	cGMP binding
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042622	cellular_component	photoreceptor outer segment membrane
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043855	molecular_function	cyclic nucleotide-activated monoatomic ion channel activity
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport
D	0098804	cellular_component	non-motile cilium membrane
D	0099094	molecular_function	ligand-gated monoatomic cation channel activity
D	0120200	cellular_component	rod photoreceptor outer segment

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. ICkKGDiGReMYIIkeG

Chain	Residue	Details
A	ILE504-GLY520
D	VAL1103-GLY1119

site_id	PS00889
Number of Residues	24
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEiSIlnikgskagnrRTAnIkS

Chain	Residue	Details
A	PHE542-SER565
D	PHE1142-ALA1162

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1175
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
D	MET1-ILE762
C	ARG216-THR241
C	GLN284-ASN291
C	ASN400-ASP690
D	ARG826-THR837
D	GLU888-ALA900
D	GLY1003-GLU1394
B	MET1-TYR163
B	ARG216-THR241
B	GLN284-ASN291
B	ASN400-ASP690
C	MET1-TYR163

site_id	SWS_FT_FI2
Number of Residues	30
Details	TRANSMEM: Helical; Name=S1 => ECO:0000269\|PubMed:37011209, ECO:0007744\|PDB:8BX7

Chain	Residue	Details
D	ASP763-ALA793
B	TYR164-ALA185
C	TYR164-ALA185

site_id	SWS_FT_FI3
Number of Residues	22
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
D	PHE794-THR798
D	LEU862-ASN872
D	TYR923-GLY931
B	CYS186-LEU195
B	ILE252-ASN264
B	TYR316-ARG342
C	CYS186-LEU195
C	ILE252-ASN264
C	TYR316-ARG342

site_id	SWS_FT_FI4
Number of Residues	26
Details	TRANSMEM: Helical; Name=S2 => ECO:0000269\|PubMed:37011209, ECO:0007744\|PDB:8BX7

Chain	Residue	Details
D	PRO799-MET825
B	GLU196-VAL215
C	GLU196-VAL215

site_id	SWS_FT_FI5
Number of Residues	23
Details	TRANSMEM: Helical; Name=S3 => ECO:0000269\|PubMed:37011209, ECO:0007744\|PDB:8BX7

Chain	Residue	Details
D	ASP838-PRO861
B	PHE242-VAL251
C	PHE242-VAL251

site_id	SWS_FT_FI6
Number of Residues	14
Details	TRANSMEM: Helical; Name=S4 => ECO:0000269\|PubMed:37011209, ECO:0007744\|PDB:8BX7

Chain	Residue	Details
D	PRO873-PHE887
B	TYR265-PHE283
C	TYR265-PHE283

site_id	SWS_FT_FI7
Number of Residues	21
Details	TRANSMEM: Helical; Name=S5 => ECO:0000269\|PubMed:37011209, ECO:0007744\|PDB:8BX7

Chain	Residue	Details
D	TYR901-LEU922
B	TYR292-VAL315
C	TYR292-VAL315

site_id	SWS_FT_FI8
Number of Residues	42
Details	TRANSMEM: Helical; Name=P-helix => ECO:0000269\|PubMed:37011209, ECO:0007744\|PDB:8BX7

Chain	Residue	Details
D	LEU932-PHE974
B	LEU343-TYR373
C	LEU343-TYR373

site_id	SWS_FT_FI9
Number of Residues	27
Details	TRANSMEM: Helical; Name=S6 => ECO:0000269\|PubMed:37011209, ECO:0007744\|PDB:8BX7

Chain	Residue	Details
D	GLN975-ALA1002
B	PHE374-SER399
C	PHE374-SER399

site_id	SWS_FT_FI10
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q14028

Chain	Residue	Details
D	GLY1143
C	SER546
C	ARG559
C	THR560
D	GLU1144
D	SER1146
D	ARG1156
D	THR1157
B	SER546
B	ARG559
B	THR560
C	GLY543

site_id	SWS_FT_FI11
Number of Residues	2
Details	SITE: Central gate => ECO:0000305\|PubMed:34969975

Chain	Residue	Details
D	PHE986
D	ILE990
B	PHE387
B	VAL391
C	PHE387
C	VAL391

site_id	SWS_FT_FI12
Number of Residues	1
Details	SITE: Occludes the pore below the central gate => ECO:0000305\|PubMed:34969975

Chain	Residue	Details
D	ARG994
B	ASN327
C	ASN327

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)