Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7O3H

Murine CIII2 focus-refined from supercomplex CICIII2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0014823	biological_process	response to activity
A	0016020	cellular_component	membrane
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0034551	biological_process	mitochondrial respiratory chain complex III assembly
A	0043209	cellular_component	myelin sheath
A	0043279	biological_process	response to alkaloid
A	0044877	molecular_function	protein-containing complex binding
A	0045275	cellular_component	respiratory chain complex III
A	0045333	biological_process	cellular respiration
A	0046872	molecular_function	metal ion binding
B	0004222	molecular_function	metalloendopeptidase activity
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006508	biological_process	proteolysis
B	0009410	biological_process	response to xenobiotic stimulus
B	0016020	cellular_component	membrane
B	0043209	cellular_component	myelin sheath
B	0044877	molecular_function	protein-containing complex binding
B	0045275	cellular_component	respiratory chain complex III
B	0045333	biological_process	cellular respiration
B	0046872	molecular_function	metal ion binding
C	0001666	biological_process	response to hypoxia
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0007584	biological_process	response to nutrient
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0009410	biological_process	response to xenobiotic stimulus
C	0009636	biological_process	response to toxic substance
C	0009725	biological_process	response to hormone
C	0015990	biological_process	electron transport coupled proton transport
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0022904	biological_process	respiratory electron transport chain
C	0031100	biological_process	animal organ regeneration
C	0032991	cellular_component	protein-containing complex
C	0033590	biological_process	response to cobalamin
C	0033762	biological_process	response to glucagon
C	0044877	molecular_function	protein-containing complex binding
C	0045275	cellular_component	respiratory chain complex III
C	0045333	biological_process	cellular respiration
C	0045471	biological_process	response to ethanol
C	0046686	biological_process	response to cadmium ion
C	0046688	biological_process	response to copper ion
C	0046689	biological_process	response to mercury ion
C	0046872	molecular_function	metal ion binding
C	0051592	biological_process	response to calcium ion
C	0055093	biological_process	response to hyperoxia
C	1904421	biological_process	response to D-galactosamine
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
E	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0016020	cellular_component	membrane
F	0045275	cellular_component	respiratory chain complex III
F	0045333	biological_process	cellular respiration
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0016020	cellular_component	membrane
G	0021539	biological_process	subthalamus development
G	0021548	biological_process	pons development
G	0021680	biological_process	cerebellar Purkinje cell layer development
G	0021766	biological_process	hippocampus development
G	0021794	biological_process	thalamus development
G	0021854	biological_process	hypothalamus development
G	0021860	biological_process	pyramidal neuron development
G	0030901	biological_process	midbrain development
G	0045275	cellular_component	respiratory chain complex III
G	0045333	biological_process	cellular respiration
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0016020	cellular_component	membrane
J	0045275	cellular_component	respiratory chain complex III
J	0045333	biological_process	cellular respiration
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
K	0016020	cellular_component	membrane
K	0045275	cellular_component	respiratory chain complex III
K	0045333	biological_process	cellular respiration
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
L	0014823	biological_process	response to activity
L	0016020	cellular_component	membrane
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0034551	biological_process	mitochondrial respiratory chain complex III assembly
L	0043209	cellular_component	myelin sheath
L	0043279	biological_process	response to alkaloid
L	0044877	molecular_function	protein-containing complex binding
L	0045275	cellular_component	respiratory chain complex III
L	0045333	biological_process	cellular respiration
L	0046872	molecular_function	metal ion binding
M	0004222	molecular_function	metalloendopeptidase activity
M	0005515	molecular_function	protein binding
M	0005654	cellular_component	nucleoplasm
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
M	0006508	biological_process	proteolysis
M	0009410	biological_process	response to xenobiotic stimulus
M	0016020	cellular_component	membrane
M	0043209	cellular_component	myelin sheath
M	0044877	molecular_function	protein-containing complex binding
M	0045275	cellular_component	respiratory chain complex III
M	0045333	biological_process	cellular respiration
M	0046872	molecular_function	metal ion binding
N	0001666	biological_process	response to hypoxia
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
N	0007584	biological_process	response to nutrient
N	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
N	0009055	molecular_function	electron transfer activity
N	0009410	biological_process	response to xenobiotic stimulus
N	0009636	biological_process	response to toxic substance
N	0009725	biological_process	response to hormone
N	0015990	biological_process	electron transport coupled proton transport
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0022904	biological_process	respiratory electron transport chain
N	0031100	biological_process	animal organ regeneration
N	0032991	cellular_component	protein-containing complex
N	0033590	biological_process	response to cobalamin
N	0033762	biological_process	response to glucagon
N	0044877	molecular_function	protein-containing complex binding
N	0045275	cellular_component	respiratory chain complex III
N	0045333	biological_process	cellular respiration
N	0045471	biological_process	response to ethanol
N	0046686	biological_process	response to cadmium ion
N	0046688	biological_process	response to copper ion
N	0046689	biological_process	response to mercury ion
N	0046872	molecular_function	metal ion binding
N	0051592	biological_process	response to calcium ion
N	0055093	biological_process	response to hyperoxia
N	1904421	biological_process	response to D-galactosamine
O	0009055	molecular_function	electron transfer activity
O	0020037	molecular_function	heme binding
P	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
P	0016020	cellular_component	membrane
P	0051537	molecular_function	2 iron, 2 sulfur cluster binding
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Q	0016020	cellular_component	membrane
Q	0045275	cellular_component	respiratory chain complex III
Q	0045333	biological_process	cellular respiration
R	0005515	molecular_function	protein binding
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
R	0016020	cellular_component	membrane
R	0021539	biological_process	subthalamus development
R	0021548	biological_process	pons development
R	0021680	biological_process	cerebellar Purkinje cell layer development
R	0021766	biological_process	hippocampus development
R	0021794	biological_process	thalamus development
R	0021854	biological_process	hypothalamus development
R	0021860	biological_process	pyramidal neuron development
R	0030901	biological_process	midbrain development
R	0045275	cellular_component	respiratory chain complex III
R	0045333	biological_process	cellular respiration
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
T	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
U	0016020	cellular_component	membrane
U	0045275	cellular_component	respiratory chain complex III
U	0045333	biological_process	cellular respiration
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
V	0016020	cellular_component	membrane
V	0045275	cellular_component	respiratory chain complex III
V	0045333	biological_process	cellular respiration

Functional Information from PROSITE/UniProt

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsryedsnnlGtSHLLRLAsSlTT

Chain	Residue	Details
B	GLY54-THR77

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0000250\|UniProtKB:P00129

Chain	Residue	Details
F	ALA1
N	MET82-TYR107
N	THR112-GLY130
N	ALA180-LEU200
N	TYR224-PHE246
N	GLY289-LEU307
N	PRO319-GLY339
N	ILE349-GLY370
Q	ALA1
S	LYS27
S	LYS70
C	TYR224-PHE246
C	GLY289-LEU307
C	PRO319-GLY339
C	ILE349-GLY370
N	SER28-MET53

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0007744\|PubMed:23806337

Chain	Residue	Details
F	LYS11
F	LYS77
F	LYS87
Q	LYS11
Q	LYS77
Q	LYS87

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:23576753

Chain	Residue	Details
F	LYS18
F	LYS82
F	LYS95
Q	LYS18
Q	LYS82
Q	LYS95

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0007744\|PubMed:23806337

Chain	Residue	Details
G	LYS32
P	SER163
R	LYS32
E	CYS158
E	HIS161
E	SER163
P	CYS139
P	HIS141
P	CYS158
P	HIS161

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:34616041, ECO:0007744\|PDB:7O37, ECO:0007744\|PDB:7O3C

Chain	Residue	Details
D	HIS41
D	MET160
O	HIS41
O	MET160

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)