7O37

Murine supercomplex CIII2CIV in the assembled locked conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0001666	biological_process	response to hypoxia
a	0004129	molecular_function	cytochrome-c oxidase activity
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0005750	cellular_component	mitochondrial respiratory chain complex III
a	0005751	cellular_component	mitochondrial respiratory chain complex IV
a	0006119	biological_process	oxidative phosphorylation
a	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
a	0006979	biological_process	response to oxidative stress
a	0009060	biological_process	aerobic respiration
a	0015990	biological_process	electron transport coupled proton transport
a	0016020	cellular_component	membrane
a	0020037	molecular_function	heme binding
a	0021549	biological_process	cerebellum development
a	0031966	cellular_component	mitochondrial membrane
a	0045277	cellular_component	respiratory chain complex IV
a	0046688	biological_process	response to copper ion
a	0046872	molecular_function	metal ion binding
a	0051602	biological_process	response to electrical stimulus
a	0070469	cellular_component	respirasome
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005750	cellular_component	mitochondrial respiratory chain complex III
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0014823	biological_process	response to activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0034551	biological_process	mitochondrial respiratory chain complex III assembly
A	0043209	cellular_component	myelin sheath
A	0043279	biological_process	response to alkaloid
A	0044877	molecular_function	protein-containing complex binding
A	0045333	biological_process	cellular respiration
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
b	0001666	biological_process	response to hypoxia
b	0004129	molecular_function	cytochrome-c oxidase activity
b	0005507	molecular_function	copper ion binding
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0005751	cellular_component	mitochondrial respiratory chain complex IV
b	0007595	biological_process	lactation
b	0016020	cellular_component	membrane
b	0016491	molecular_function	oxidoreductase activity
b	0022900	biological_process	electron transport chain
b	0031966	cellular_component	mitochondrial membrane
b	0042773	biological_process	ATP synthesis coupled electron transport
b	0045277	cellular_component	respiratory chain complex IV
b	0046872	molecular_function	metal ion binding
b	0070469	cellular_component	respirasome
b	1902600	biological_process	proton transmembrane transport
B	0004222	molecular_function	metalloendopeptidase activity
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005750	cellular_component	mitochondrial respiratory chain complex III
B	0005751	cellular_component	mitochondrial respiratory chain complex IV
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006508	biological_process	proteolysis
B	0009410	biological_process	response to xenobiotic stimulus
B	0043209	cellular_component	myelin sheath
B	0044877	molecular_function	protein-containing complex binding
B	0045275	cellular_component	respiratory chain complex III
B	0045333	biological_process	cellular respiration
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
c	0004129	molecular_function	cytochrome-c oxidase activity
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0005751	cellular_component	mitochondrial respiratory chain complex IV
c	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
c	0008535	biological_process	respiratory chain complex IV assembly
c	0009055	molecular_function	electron transfer activity
c	0016020	cellular_component	membrane
c	0019646	biological_process	aerobic electron transport chain
c	0022904	biological_process	respiratory electron transport chain
c	0031966	cellular_component	mitochondrial membrane
c	0045277	cellular_component	respiratory chain complex IV
c	1902600	biological_process	proton transmembrane transport
C	0001666	biological_process	response to hypoxia
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005750	cellular_component	mitochondrial respiratory chain complex III
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0007584	biological_process	response to nutrient
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0009410	biological_process	response to xenobiotic stimulus
C	0009636	biological_process	response to toxic substance
C	0009725	biological_process	response to hormone
C	0010243	biological_process	response to organonitrogen compound
C	0014070	biological_process	response to organic cyclic compound
C	0015990	biological_process	electron transport coupled proton transport
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0022904	biological_process	respiratory electron transport chain
C	0031100	biological_process	animal organ regeneration
C	0032991	cellular_component	protein-containing complex
C	0033590	biological_process	response to cobalamin
C	0033762	biological_process	response to glucagon
C	0044877	molecular_function	protein-containing complex binding
C	0045275	cellular_component	respiratory chain complex III
C	0045333	biological_process	cellular respiration
C	0045471	biological_process	response to ethanol
C	0046686	biological_process	response to cadmium ion
C	0046688	biological_process	response to copper ion
C	0046689	biological_process	response to mercury ion
C	0046872	molecular_function	metal ion binding
C	0051592	biological_process	response to calcium ion
C	0055093	biological_process	response to hyperoxia
C	0070469	cellular_component	respirasome
d	0005751	cellular_component	mitochondrial respiratory chain complex IV
d	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
e	0005743	cellular_component	mitochondrial inner membrane
e	0005751	cellular_component	mitochondrial respiratory chain complex IV
e	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
E	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
f	0005740	cellular_component	mitochondrial envelope
f	0005751	cellular_component	mitochondrial respiratory chain complex IV
f	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005750	cellular_component	mitochondrial respiratory chain complex III
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0070469	cellular_component	respirasome
g	0005743	cellular_component	mitochondrial inner membrane
g	0005751	cellular_component	mitochondrial respiratory chain complex IV
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005750	cellular_component	mitochondrial respiratory chain complex III
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0021539	biological_process	subthalamus development
G	0021548	biological_process	pons development
G	0021680	biological_process	cerebellar Purkinje cell layer development
G	0021766	biological_process	hippocampus development
G	0021794	biological_process	thalamus development
G	0021854	biological_process	hypothalamus development
G	0021860	biological_process	pyramidal neuron development
G	0030901	biological_process	midbrain development
G	0045333	biological_process	cellular respiration
G	0070469	cellular_component	respirasome
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0005751	cellular_component	mitochondrial respiratory chain complex IV
h	0006119	biological_process	oxidative phosphorylation
h	0031966	cellular_component	mitochondrial membrane
h	0045277	cellular_component	respiratory chain complex IV
H	0005750	cellular_component	mitochondrial respiratory chain complex III
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
i	0003674	molecular_function	molecular_function
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0005751	cellular_component	mitochondrial respiratory chain complex IV
i	0006119	biological_process	oxidative phosphorylation
i	0008150	biological_process	biological_process
i	0031966	cellular_component	mitochondrial membrane
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005746	cellular_component	mitochondrial respirasome
I	0005751	cellular_component	mitochondrial respiratory chain complex IV
I	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005750	cellular_component	mitochondrial respiratory chain complex III
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0045333	biological_process	cellular respiration
J	0070469	cellular_component	respirasome
k	0005746	cellular_component	mitochondrial respirasome
k	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005750	cellular_component	mitochondrial respiratory chain complex III
K	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
K	0045333	biological_process	cellular respiration
K	0070469	cellular_component	respirasome
l	0005751	cellular_component	mitochondrial respiratory chain complex IV
l	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005750	cellular_component	mitochondrial respiratory chain complex III
L	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
L	0014823	biological_process	response to activity
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0034551	biological_process	mitochondrial respiratory chain complex III assembly
L	0043209	cellular_component	myelin sheath
L	0043279	biological_process	response to alkaloid
L	0044877	molecular_function	protein-containing complex binding
L	0045333	biological_process	cellular respiration
L	0046872	molecular_function	metal ion binding
L	0070469	cellular_component	respirasome
m	0005751	cellular_component	mitochondrial respiratory chain complex IV
m	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
M	0004222	molecular_function	metalloendopeptidase activity
M	0005515	molecular_function	protein binding
M	0005654	cellular_component	nucleoplasm
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005750	cellular_component	mitochondrial respiratory chain complex III
M	0005751	cellular_component	mitochondrial respiratory chain complex IV
M	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
M	0006508	biological_process	proteolysis
M	0009410	biological_process	response to xenobiotic stimulus
M	0043209	cellular_component	myelin sheath
M	0044877	molecular_function	protein-containing complex binding
M	0045275	cellular_component	respiratory chain complex III
M	0045333	biological_process	cellular respiration
M	0046872	molecular_function	metal ion binding
M	0070469	cellular_component	respirasome
N	0001666	biological_process	response to hypoxia
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005750	cellular_component	mitochondrial respiratory chain complex III
N	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
N	0007584	biological_process	response to nutrient
N	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
N	0009055	molecular_function	electron transfer activity
N	0009410	biological_process	response to xenobiotic stimulus
N	0009636	biological_process	response to toxic substance
N	0009725	biological_process	response to hormone
N	0010243	biological_process	response to organonitrogen compound
N	0014070	biological_process	response to organic cyclic compound
N	0015990	biological_process	electron transport coupled proton transport
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0022904	biological_process	respiratory electron transport chain
N	0031100	biological_process	animal organ regeneration
N	0032991	cellular_component	protein-containing complex
N	0033590	biological_process	response to cobalamin
N	0033762	biological_process	response to glucagon
N	0044877	molecular_function	protein-containing complex binding
N	0045275	cellular_component	respiratory chain complex III
N	0045333	biological_process	cellular respiration
N	0045471	biological_process	response to ethanol
N	0046686	biological_process	response to cadmium ion
N	0046688	biological_process	response to copper ion
N	0046689	biological_process	response to mercury ion
N	0046872	molecular_function	metal ion binding
N	0051592	biological_process	response to calcium ion
N	0055093	biological_process	response to hyperoxia
N	0070469	cellular_component	respirasome
O	0009055	molecular_function	electron transfer activity
O	0020037	molecular_function	heme binding
P	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
P	0016020	cellular_component	membrane
P	0051537	molecular_function	2 iron, 2 sulfur cluster binding
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005750	cellular_component	mitochondrial respiratory chain complex III
Q	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Q	0070469	cellular_component	respirasome
R	0005515	molecular_function	protein binding
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005750	cellular_component	mitochondrial respiratory chain complex III
R	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
R	0021539	biological_process	subthalamus development
R	0021548	biological_process	pons development
R	0021680	biological_process	cerebellar Purkinje cell layer development
R	0021766	biological_process	hippocampus development
R	0021794	biological_process	thalamus development
R	0021854	biological_process	hypothalamus development
R	0021860	biological_process	pyramidal neuron development
R	0030901	biological_process	midbrain development
R	0045333	biological_process	cellular respiration
R	0070469	cellular_component	respirasome
S	0005750	cellular_component	mitochondrial respiratory chain complex III
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
T	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0005750	cellular_component	mitochondrial respiratory chain complex III
U	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
U	0045333	biological_process	cellular respiration
U	0070469	cellular_component	respirasome
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0005750	cellular_component	mitochondrial respiratory chain complex III
V	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
V	0045333	biological_process	cellular respiration
V	0070469	cellular_component	respirasome

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	56
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgiishvvtyysgkkepfgymgmvwammsigflgfivwa.HH

Chain	Residue	Details
a	TRP236-HIS291

---

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqatvtsnrpglfygq......CseiCgsnHsfM

Chain	Residue	Details
b	VAL159-MET207

---

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsryedsnnlGtSHLLRLAsSlTT

Chain	Residue	Details
B	GLY54-THR77

---

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgesqrCpnCGthYKL

Chain	Residue	Details
f	VAL70-LEU92

---

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFaWGDGnHTlFhN

Chain	Residue	Details
g	ILE55-ASN72

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000250|UniProtKB:P00430

Chain	Residue	Details
l	SER1-ASN17
N	TRP77-VAL98
N	TRP113-LEU133
N	PHE178-LEU198
N	ILE226-PHE246
N	LEU288-HIS308
N	ILE320-GLY340
N	PHE347-PRO367
f	CYS63
f	CYS83
f	CYS86
a	HIS328-SER335
a	SER401-ASP406
a	LYS479-LYS514
C	PHE347-PRO367
N	PHE33-MET53

---

site_id	SWS_FT_FI2
Number of Residues	26
Details	TRANSMEM: Helical => ECO:0000250|UniProtKB:P00430

Chain	Residue	Details
l	LYS18-LEU44
f	LYS56
f	LYS91

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000250|UniProtKB:P00430

Chain	Residue	Details
l	LEU45-LYS47
c	LEU106-GLU128
c	THR184-ASP190
c	TYR257-SER261
a	LEU358-THR370
a	SER434-ALA446

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0007744|PubMed:23806337

Chain	Residue	Details
l	LYS9
P	SER163
d	LYS38
E	CYS158
E	HIS161
E	SER163
P	CYS139
P	HIS141
P	CYS158
P	HIS161

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10888

Chain	Residue	Details
d	SER34
d	SER36
b	GLU198
b	CYS200
b	HIS204
b	MET207

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23576753

Chain	Residue	Details
d	LYS45

---

site_id	SWS_FT_FI7
Number of Residues	27
Details	TRANSMEM: Helical; Name=V => ECO:0000250|UniProtKB:P00415

Chain	Residue	Details
c	ARG156-GLU183

---

site_id	SWS_FT_FI8
Number of Residues	32
Details	TRANSMEM: Helical; Name=VI => ECO:0000250|UniProtKB:P00415

Chain	Residue	Details
c	GLY191-LEU223

---

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=VII => ECO:0000250|UniProtKB:P00415

Chain	Residue	Details
c	PHE233-ILE256

---

site_id	SWS_FT_FI10
Number of Residues	28
Details	TRANSMEM: Helical; Name=VIII => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
a	VAL299-LEU327

---

site_id	SWS_FT_FI11
Number of Residues	21
Details	TRANSMEM: Helical; Name=IX => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
a	PRO336-VAL357

---

site_id	SWS_FT_FI12
Number of Residues	29
Details	TRANSMEM: Helical; Name=X => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
a	TYR371-PHE400

---

site_id	SWS_FT_FI13
Number of Residues	26
Details	TRANSMEM: Helical; Name=XI => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
a	ASP407-LEU433

---

site_id	SWS_FT_FI14
Number of Residues	31
Details	TRANSMEM: Helical; Name=XII => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
a	TYR447-SER478

---

site_id	SWS_FT_FI15
Number of Residues	9
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
a	GLU40
a	GLY45
a	HIS240
a	TYR244
a	HIS290
a	HIS291
a	HIS368
a	ASP369
a	SER441

---

site_id	SWS_FT_FI16
Number of Residues	3
Details	BINDING: axial binding residue => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
a	HIS61
a	HIS376
a	HIS378

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
a	HIS240
a	TYR244

---