7O1Q
Amyloid beta oligomer displayed on the alpha hemolysin scaffold
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0016020 | cellular_component | membrane |
| A | 0051715 | biological_process | cytolysis in another organism |
| B | 0005576 | cellular_component | extracellular region |
| B | 0016020 | cellular_component | membrane |
| B | 0051715 | biological_process | cytolysis in another organism |
| C | 0005576 | cellular_component | extracellular region |
| C | 0016020 | cellular_component | membrane |
| C | 0051715 | biological_process | cytolysis in another organism |
| D | 0005576 | cellular_component | extracellular region |
| D | 0016020 | cellular_component | membrane |
| D | 0051715 | biological_process | cytolysis in another organism |
| E | 0005576 | cellular_component | extracellular region |
| E | 0016020 | cellular_component | membrane |
| E | 0051715 | biological_process | cytolysis in another organism |
| F | 0005576 | cellular_component | extracellular region |
| F | 0016020 | cellular_component | membrane |
| F | 0051715 | biological_process | cytolysis in another organism |
| G | 0005576 | cellular_component | extracellular region |
| G | 0016020 | cellular_component | membrane |
| G | 0051715 | biological_process | cytolysis in another organism |
Functional Information from PROSITE/UniProt
| site_id | PS00274 |
| Number of Residues | 10 |
| Details | AEROLYSIN Aerolysin type toxins signature. TstNWkgTNT |
| Chain | Residue | Details |
| A | THR261-THR270 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 175 |
| Details | Peptide: {"description":"P3(42)","featureId":"PRO_0000000095"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 161 |
| Details | Peptide: {"description":"P3(40)","featureId":"PRO_0000000096"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26898943","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10413512","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10413512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11274207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26898943","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 7 |
| Details | Site: {"description":"Cleavage; by caspase-6; when associated with variant 670-N-L-671"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 7 |
| Details | Site: {"description":"Cleavage; by ACE","evidences":[{"source":"PubMed","id":"11604391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16154999","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 7 |
| Details | Site: {"description":"Cleavage; by alpha-secretase","evidences":[{"source":"PubMed","id":"11851430","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 7 |
| Details | Site: {"description":"Cleavage; by theta-secretase","evidences":[{"source":"PubMed","id":"16816112","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 7 |
| Details | Site: {"description":"Implicated in free radical propagation","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 7 |
| Details | Site: {"description":"Susceptible to oxidation","evidences":[{"source":"PubMed","id":"10535332","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 7 |
| Details | Site: {"description":"Cleavage; by gamma-secretase; site 1","evidences":[{"source":"PubMed","id":"11851430","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 7 |
| Details | Site: {"description":"Cleavage; by gamma-secretase; site 2","evidences":[{"source":"PubMed","id":"11851430","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 7 |
| Details | Glycosylation: {"description":"O-linked (HexNAc...) tyrosine; partial","evidences":[{"source":"PubMed","id":"22576872","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
