7O0L

Crystal structure of the human METTL3-METTL14 complex bound to Compound 8 (ADO_AC_093)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001510	biological_process	RNA methylation
A	0001734	molecular_function	mRNA m(6)A methyltransferase activity
A	0005634	cellular_component	nucleus

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27627798, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2, ECO:0007744|PDB:5K7U, ECO:0007744|PDB:5K7W, ECO:0007744|PDB:5L6D, ECO:0007744|PDB:5L6E

Chain	Residue	Details
A	ASP377
A	ARG536
A	ASN549
B	ARG298

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2, ECO:0007744|PDB:5K7U, ECO:0007744|PDB:5K7W

Chain	Residue	Details
A	ASP395
A	LYS513

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Interaction with METTL14 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2

Chain	Residue	Details
A	GLU438
A	ARG441

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