7NYH

Respiratory complex I from Escherichia coli - focused refinement of membrane arm

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003954	molecular_function	NADH dehydrogenase activity
A	0005886	cellular_component	plasma membrane
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0016020	cellular_component	membrane
A	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
A	0022904	biological_process	respiratory electron transport chain
A	0030964	cellular_component	NADH dehydrogenase complex
A	0045271	cellular_component	respiratory chain complex I
A	0048038	molecular_function	quinone binding
A	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
A	1902600	biological_process	proton transmembrane transport
H	0003954	molecular_function	NADH dehydrogenase activity
H	0005886	cellular_component	plasma membrane
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
H	0022904	biological_process	respiratory electron transport chain
H	0030964	cellular_component	NADH dehydrogenase complex
H	0045271	cellular_component	respiratory chain complex I
H	0048038	molecular_function	quinone binding
H	1902600	biological_process	proton transmembrane transport
J	0003954	molecular_function	NADH dehydrogenase activity
J	0005886	cellular_component	plasma membrane
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0016020	cellular_component	membrane
J	0022904	biological_process	respiratory electron transport chain
J	0030964	cellular_component	NADH dehydrogenase complex
J	0045271	cellular_component	respiratory chain complex I
J	0048038	molecular_function	quinone binding
J	1902600	biological_process	proton transmembrane transport
K	0003954	molecular_function	NADH dehydrogenase activity
K	0005515	molecular_function	protein binding
K	0005886	cellular_component	plasma membrane
K	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
K	0016020	cellular_component	membrane
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0022904	biological_process	respiratory electron transport chain
K	0030964	cellular_component	NADH dehydrogenase complex
K	0042773	biological_process	ATP synthesis coupled electron transport
K	0045271	cellular_component	respiratory chain complex I
K	0048038	molecular_function	quinone binding
K	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
K	1902600	biological_process	proton transmembrane transport
L	0003954	molecular_function	NADH dehydrogenase activity
L	0005886	cellular_component	plasma membrane
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0015990	biological_process	electron transport coupled proton transport
L	0016020	cellular_component	membrane
L	0022904	biological_process	respiratory electron transport chain
L	0030964	cellular_component	NADH dehydrogenase complex
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0045271	cellular_component	respiratory chain complex I
L	0048038	molecular_function	quinone binding
M	0003954	molecular_function	NADH dehydrogenase activity
M	0005886	cellular_component	plasma membrane
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009060	biological_process	aerobic respiration
M	0015990	biological_process	electron transport coupled proton transport
M	0016020	cellular_component	membrane
M	0022904	biological_process	respiratory electron transport chain
M	0030964	cellular_component	NADH dehydrogenase complex
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0045271	cellular_component	respiratory chain complex I
M	0048038	molecular_function	quinone binding
M	0048039	molecular_function	ubiquinone binding
N	0003954	molecular_function	NADH dehydrogenase activity
N	0005886	cellular_component	plasma membrane
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0009060	biological_process	aerobic respiration
N	0015990	biological_process	electron transport coupled proton transport
N	0016020	cellular_component	membrane
N	0022904	biological_process	respiratory electron transport chain
N	0030964	cellular_component	NADH dehydrogenase complex
N	0042773	biological_process	ATP synthesis coupled electron transport
N	0045271	cellular_component	respiratory chain complex I
N	0048038	molecular_function	quinone binding
N	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity

Functional Information from PROSITE/UniProt

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GSLQlVaDMIKMFfKE

Chain	Residue	Details
H	GLY56-GLU71

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site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDQPEAEq.ELadG

Chain	Residue	Details
H	PRO211-GLY224

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	168
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
L	MET1-LEU6
M	GLY340-GLY360
M	TRP383-ASN403
M	PHE404-ILE424
M	THR426-GLY446
M	LEU465-ILE485
L	PHE53-ASN74
L	ASP134-ASP210
L	ARG268-HIS281
L	GLN326-HIS338
L	SER398-ASN413
L	PRO473-GLU494
L	LEU608-ARG613
M	LEU314-SER334

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site_id	SWS_FT_FI2
Number of Residues	264
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
L	THR7-GLY23
L	LEU374-PHE397
L	LEU414-PHE437
L	LEU455-VAL472
L	ILE495-GLY514
L	TYR590-ALA607
L	ILE32-PHE52
L	ILE75-ILE99
L	PHE116-ALA133
L	GLY211-GLY228
L	VAL249-ALA267
L	LEU282-VAL300
L	VAL307-VAL325
L	ALA339-CYS356

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site_id	SWS_FT_FI3
Number of Residues	152
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
L	ARG24-ALA31
L	HIS100-ARG115
L	LYS229-PRO248
L	GLN301-ARG306
L	HIS357-PRO373
L	HIS438-SER454
L	LYS515-GLY589

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