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7NYC

cryoEM structure of 3C9-sMAC

Functional Information from GO Data
ChainGOidnamespacecontents
A0001664molecular_functionG protein-coupled receptor binding
A0002376biological_processimmune system process
A0002682biological_processregulation of immune system process
A0004866molecular_functionendopeptidase inhibitor activity
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005579cellular_componentmembrane attack complex
A0005615cellular_componentextracellular space
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006956biological_processcomplement activation
A0006957biological_processcomplement activation, alternative pathway
A0006958biological_processcomplement activation, classical pathway
A0007166biological_processcell surface receptor signaling pathway
A0007186biological_processG protein-coupled receptor signaling pathway
A0008009molecular_functionchemokine activity
A0010575biological_processpositive regulation of vascular endothelial growth factor production
A0010760biological_processnegative regulation of macrophage chemotaxis
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0031640biological_processkilling of cells of another organism
A0032722biological_processpositive regulation of chemokine production
A0044218cellular_componentother organism cell membrane
A0045087biological_processinnate immune response
A0050920biological_processregulation of chemotaxis
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0160257
B0001701biological_processin utero embryonic development
B0002376biological_processimmune system process
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005579cellular_componentmembrane attack complex
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0006955biological_processimmune response
B0006956biological_processcomplement activation
B0006958biological_processcomplement activation, classical pathway
B0016020cellular_componentmembrane
B0031640biological_processkilling of cells of another organism
B0044218cellular_componentother organism cell membrane
B0045087biological_processinnate immune response
B0050778biological_processpositive regulation of immune response
B0070062cellular_componentextracellular exosome
B0160257
B1902495cellular_componenttransmembrane transporter complex
C0002376biological_processimmune system process
C0005576cellular_componentextracellular region
C0005579cellular_componentmembrane attack complex
C0005615cellular_componentextracellular space
C0005886cellular_componentplasma membrane
C0006955biological_processimmune response
C0006956biological_processcomplement activation
C0006957biological_processcomplement activation, alternative pathway
C0006958biological_processcomplement activation, classical pathway
C0016020cellular_componentmembrane
C0031640biological_processkilling of cells of another organism
C0044218cellular_componentother organism cell membrane
C0045087biological_processinnate immune response
C0050778biological_processpositive regulation of immune response
C0070062cellular_componentextracellular exosome
C0160257
C1902495cellular_componenttransmembrane transporter complex
D0002376biological_processimmune system process
D0005576cellular_componentextracellular region
D0005579cellular_componentmembrane attack complex
D0005615cellular_componentextracellular space
D0005886cellular_componentplasma membrane
D0006955biological_processimmune response
D0006956biological_processcomplement activation
D0006957biological_processcomplement activation, alternative pathway
D0006958biological_processcomplement activation, classical pathway
D0016020cellular_componentmembrane
D0031640biological_processkilling of cells of another organism
D0044218cellular_componentother organism cell membrane
D0044877molecular_functionprotein-containing complex binding
D0045087biological_processinnate immune response
D0050778biological_processpositive regulation of immune response
D0070062cellular_componentextracellular exosome
D0160257
D1902495cellular_componenttransmembrane transporter complex
D1903561cellular_componentextracellular vesicle
E0001848molecular_functioncomplement binding
E0002376biological_processimmune system process
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005579cellular_componentmembrane attack complex
E0005615cellular_componentextracellular space
E0005886cellular_componentplasma membrane
E0006955biological_processimmune response
E0006956biological_processcomplement activation
E0006957biological_processcomplement activation, alternative pathway
E0006958biological_processcomplement activation, classical pathway
E0016020cellular_componentmembrane
E0031640biological_processkilling of cells of another organism
E0044218cellular_componentother organism cell membrane
E0044877molecular_functionprotein-containing complex binding
E0045087biological_processinnate immune response
E0050778biological_processpositive regulation of immune response
E0070062cellular_componentextracellular exosome
E0072562cellular_componentblood microparticle
E0160257
E1902495cellular_componenttransmembrane transporter complex
F0002376biological_processimmune system process
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005579cellular_componentmembrane attack complex
F0005886cellular_componentplasma membrane
F0006956biological_processcomplement activation
F0006957biological_processcomplement activation, alternative pathway
F0006958biological_processcomplement activation, classical pathway
F0016020cellular_componentmembrane
F0019841molecular_functionretinol binding
F0031640biological_processkilling of cells of another organism
F0044218cellular_componentother organism cell membrane
F0045087biological_processinnate immune response
F0050778biological_processpositive regulation of immune response
F0070062cellular_componentextracellular exosome
F0072562cellular_componentblood microparticle
F0160257
F1902495cellular_componenttransmembrane transporter complex
G0001906biological_processcell killing
G0002376biological_processimmune system process
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005579cellular_componentmembrane attack complex
G0005615cellular_componentextracellular space
G0005886cellular_componentplasma membrane
G0006955biological_processimmune response
G0006956biological_processcomplement activation
G0006957biological_processcomplement activation, alternative pathway
G0006958biological_processcomplement activation, classical pathway
G0016020cellular_componentmembrane
G0031640biological_processkilling of cells of another organism
G0044218cellular_componentother organism cell membrane
G0045087biological_processinnate immune response
G0050778biological_processpositive regulation of immune response
G0051260biological_processprotein homooligomerization
G0070062cellular_componentextracellular exosome
G0072562cellular_componentblood microparticle
G0160257
G1902495cellular_componenttransmembrane transporter complex
H0001906biological_processcell killing
H0002376biological_processimmune system process
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005579cellular_componentmembrane attack complex
H0005615cellular_componentextracellular space
H0005886cellular_componentplasma membrane
H0006955biological_processimmune response
H0006956biological_processcomplement activation
H0006957biological_processcomplement activation, alternative pathway
H0006958biological_processcomplement activation, classical pathway
H0016020cellular_componentmembrane
H0031640biological_processkilling of cells of another organism
H0044218cellular_componentother organism cell membrane
H0045087biological_processinnate immune response
H0050778biological_processpositive regulation of immune response
H0051260biological_processprotein homooligomerization
H0070062cellular_componentextracellular exosome
H0072562cellular_componentblood microparticle
H0160257
H1902495cellular_componenttransmembrane transporter complex
I0001906biological_processcell killing
I0002376biological_processimmune system process
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005579cellular_componentmembrane attack complex
I0005615cellular_componentextracellular space
I0005886cellular_componentplasma membrane
I0006955biological_processimmune response
I0006956biological_processcomplement activation
I0006957biological_processcomplement activation, alternative pathway
I0006958biological_processcomplement activation, classical pathway
I0016020cellular_componentmembrane
I0031640biological_processkilling of cells of another organism
I0044218cellular_componentother organism cell membrane
I0045087biological_processinnate immune response
I0050778biological_processpositive regulation of immune response
I0051260biological_processprotein homooligomerization
I0070062cellular_componentextracellular exosome
I0072562cellular_componentblood microparticle
I0160257
I1902495cellular_componenttransmembrane transporter complex
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CiCpvGsqGLaC
ChainResidueDetails
DCYS469-CYS480
CCYS453-CYS464
ECYS487-CYS498
BCYS520-CYS531
GCYS507-CYS518

site_idPS00213
Number of Residues14
DetailsLIPOCALIN Lipocalin signature. NFDaqQFAGTWLLV
ChainResidueDetails
FASN21-VAL34

site_idPS00279
Number of Residues12
DetailsMACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YrdlfrdFGTHY
ChainResidueDetails
DTYR279-TYR290
CTYR270-TYR281
ETYR300-TYR311
BTYR333-TYR344
GTYR314-TYR325

site_idPS01177
Number of Residues35
DetailsANAPHYLATOXIN_1 Anaphylatoxin domain signature. CCydGacvnnde.TCEqraarisl.GprCikafte.CC
ChainResidueDetails
ACYS680-CYS714

site_idPS01186
Number of Residues16
DetailsEGF_2 EGF-like domain signature 2. CvCkmPYecgpsldvC
ChainResidueDetails
CCYS691-CYS706
GCYS505-CYS518

site_idPS01209
Number of Residues23
DetailsLDLRA_1 LDL-receptor class A (LDLRA) domain signature. CVnrrll.CNgdnDCgdq.SDEan...C
ChainResidueDetails
DCYS79-CYS101
CCYS74-CYS97
ECYS78-CYS100
BCYS130-CYS152
GCYS91-CYS113

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:3676249
ChainResidueDetails
FGLN1
GTYR314-GLY333
HVAL293-TYR309
HTYR314-GLY333
IVAL293-TYR309
ITYR314-GLY333

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:18536718, ECO:0000269|PubMed:21217642, ECO:0007744|PDB:3CU7, ECO:0007744|PDB:3KLS, ECO:0007744|PDB:3KM9
ChainResidueDetails
AASN893
BTRP69
BTRP547
BTRP550
BTRP553

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN1097
BTHR371
ITRP27

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952
ChainResidueDetails
AASN1612
HTRP30
ITRP30

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952
ChainResidueDetails
BASN834
HASN256
IASN256

site_idSWS_FT_FI6
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:4055801
ChainResidueDetails
GASN394
HASN394
IASN394

237423

PDB entries from 2025-06-11

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