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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7NYC

cryoEM structure of 3C9-sMAC

Functional Information from GO Data
ChainGOidnamespacecontents
A0001664molecular_functionG protein-coupled receptor binding
A0002376biological_processimmune system process
A0002682biological_processregulation of immune system process
A0004866molecular_functionendopeptidase inhibitor activity
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005579cellular_componentmembrane attack complex
A0005615cellular_componentextracellular space
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006956biological_processcomplement activation
A0006957biological_processcomplement activation, alternative pathway
A0006958biological_processcomplement activation, classical pathway
A0007166biological_processcell surface receptor signaling pathway
A0007186biological_processG protein-coupled receptor signaling pathway
A0008009molecular_functionchemokine activity
A0010575biological_processpositive regulation of vascular endothelial growth factor production
A0010760biological_processnegative regulation of macrophage chemotaxis
A0016477biological_processcell migration
A0031640biological_processkilling of cells of another organism
A0032722biological_processpositive regulation of chemokine production
A0044218cellular_componentother organism cell membrane
A0045087biological_processinnate immune response
A0050920biological_processregulation of chemotaxis
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0160257biological_processcomplement activation, GZMK pathway
B0001970biological_processpositive regulation of activation of membrane attack complex
B0002376biological_processimmune system process
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005579cellular_componentmembrane attack complex
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0006955biological_processimmune response
B0006956biological_processcomplement activation
B0006958biological_processcomplement activation, classical pathway
B0022829molecular_functionwide pore channel activity
B0031640biological_processkilling of cells of another organism
B0044218cellular_componentother organism cell membrane
B0045087biological_processinnate immune response
B0045766biological_processpositive regulation of angiogenesis
B0045917biological_processpositive regulation of complement activation
B0050778biological_processpositive regulation of immune response
B0055085biological_processtransmembrane transport
B0070062cellular_componentextracellular exosome
B0160257biological_processcomplement activation, GZMK pathway
C0002376biological_processimmune system process
C0005576cellular_componentextracellular region
C0005579cellular_componentmembrane attack complex
C0005615cellular_componentextracellular space
C0005886cellular_componentplasma membrane
C0006955biological_processimmune response
C0006956biological_processcomplement activation
C0006957biological_processcomplement activation, alternative pathway
C0006958biological_processcomplement activation, classical pathway
C0022829molecular_functionwide pore channel activity
C0031640biological_processkilling of cells of another organism
C0044218cellular_componentother organism cell membrane
C0045087biological_processinnate immune response
C0050778biological_processpositive regulation of immune response
C0055085biological_processtransmembrane transport
C0070062cellular_componentextracellular exosome
C0160257biological_processcomplement activation, GZMK pathway
D0002376biological_processimmune system process
D0005576cellular_componentextracellular region
D0005579cellular_componentmembrane attack complex
D0005615cellular_componentextracellular space
D0005886cellular_componentplasma membrane
D0006955biological_processimmune response
D0006956biological_processcomplement activation
D0006957biological_processcomplement activation, alternative pathway
D0006958biological_processcomplement activation, classical pathway
D0016020cellular_componentmembrane
D0022829molecular_functionwide pore channel activity
D0031640biological_processkilling of cells of another organism
D0044218cellular_componentother organism cell membrane
D0044877molecular_functionprotein-containing complex binding
D0045087biological_processinnate immune response
D0050778biological_processpositive regulation of immune response
D0055085biological_processtransmembrane transport
D0070062cellular_componentextracellular exosome
D0160257biological_processcomplement activation, GZMK pathway
D1903561cellular_componentextracellular vesicle
E0001848molecular_functioncomplement binding
E0002376biological_processimmune system process
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005579cellular_componentmembrane attack complex
E0005615cellular_componentextracellular space
E0005886cellular_componentplasma membrane
E0006955biological_processimmune response
E0006956biological_processcomplement activation
E0006957biological_processcomplement activation, alternative pathway
E0006958biological_processcomplement activation, classical pathway
E0016020cellular_componentmembrane
E0022829molecular_functionwide pore channel activity
E0031640biological_processkilling of cells of another organism
E0044218cellular_componentother organism cell membrane
E0044877molecular_functionprotein-containing complex binding
E0045087biological_processinnate immune response
E0050778biological_processpositive regulation of immune response
E0055085biological_processtransmembrane transport
E0070062cellular_componentextracellular exosome
E0072562cellular_componentblood microparticle
E0160257biological_processcomplement activation, GZMK pathway
F0002376biological_processimmune system process
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005579cellular_componentmembrane attack complex
F0005886cellular_componentplasma membrane
F0006956biological_processcomplement activation
F0006957biological_processcomplement activation, alternative pathway
F0006958biological_processcomplement activation, classical pathway
F0019841molecular_functionretinol binding
F0022829molecular_functionwide pore channel activity
F0031640biological_processkilling of cells of another organism
F0044218cellular_componentother organism cell membrane
F0045087biological_processinnate immune response
F0050778biological_processpositive regulation of immune response
F0055085biological_processtransmembrane transport
F0070062cellular_componentextracellular exosome
F0072562cellular_componentblood microparticle
F0160257biological_processcomplement activation, GZMK pathway
G0001906biological_processcell killing
G0002376biological_processimmune system process
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005579cellular_componentmembrane attack complex
G0005615cellular_componentextracellular space
G0005886cellular_componentplasma membrane
G0006955biological_processimmune response
G0006956biological_processcomplement activation
G0006957biological_processcomplement activation, alternative pathway
G0006958biological_processcomplement activation, classical pathway
G0022829molecular_functionwide pore channel activity
G0031640biological_processkilling of cells of another organism
G0044218cellular_componentother organism cell membrane
G0045087biological_processinnate immune response
G0050778biological_processpositive regulation of immune response
G0051260biological_processprotein homooligomerization
G0055085biological_processtransmembrane transport
G0070062cellular_componentextracellular exosome
G0072562cellular_componentblood microparticle
G0160257biological_processcomplement activation, GZMK pathway
H0001906biological_processcell killing
H0002376biological_processimmune system process
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005579cellular_componentmembrane attack complex
H0005615cellular_componentextracellular space
H0005886cellular_componentplasma membrane
H0006955biological_processimmune response
H0006956biological_processcomplement activation
H0006957biological_processcomplement activation, alternative pathway
H0006958biological_processcomplement activation, classical pathway
H0022829molecular_functionwide pore channel activity
H0031640biological_processkilling of cells of another organism
H0044218cellular_componentother organism cell membrane
H0045087biological_processinnate immune response
H0050778biological_processpositive regulation of immune response
H0051260biological_processprotein homooligomerization
H0055085biological_processtransmembrane transport
H0070062cellular_componentextracellular exosome
H0072562cellular_componentblood microparticle
H0160257biological_processcomplement activation, GZMK pathway
I0001906biological_processcell killing
I0002376biological_processimmune system process
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005579cellular_componentmembrane attack complex
I0005615cellular_componentextracellular space
I0005886cellular_componentplasma membrane
I0006955biological_processimmune response
I0006956biological_processcomplement activation
I0006957biological_processcomplement activation, alternative pathway
I0006958biological_processcomplement activation, classical pathway
I0022829molecular_functionwide pore channel activity
I0031640biological_processkilling of cells of another organism
I0044218cellular_componentother organism cell membrane
I0045087biological_processinnate immune response
I0050778biological_processpositive regulation of immune response
I0051260biological_processprotein homooligomerization
I0055085biological_processtransmembrane transport
I0070062cellular_componentextracellular exosome
I0072562cellular_componentblood microparticle
I0160257biological_processcomplement activation, GZMK pathway
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CvCqsGtyGEnC
ChainResidueDetails
BCYS520-CYS531
DCYS469-CYS480
CCYS453-CYS464
GCYS507-CYS518
ECYS487-CYS498
site_idPS00213
Number of Residues14
DetailsLIPOCALIN Lipocalin signature. NFDaqQFAGTWLLV
ChainResidueDetails
FASN21-VAL34
site_idPS00279
Number of Residues12
DetailsMACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YsrifddFGTHY
ChainResidueDetails
BTYR333-TYR344
DTYR279-TYR290
CTYR270-TYR281
GTYR314-TYR325
ETYR300-TYR311
site_idPS01177
Number of Residues35
DetailsANAPHYLATOXIN_1 Anaphylatoxin domain signature. CCydGacvnnde.TCEqraarisl.GprCikafte.CC
ChainResidueDetails
ACYS680-CYS714
site_idPS01186
Number of Residues16
DetailsEGF_2 EGF-like domain signature 2. CvCkmPYecgpsldvC
ChainResidueDetails
CCYS691-CYS706
GCYS505-CYS518
site_idPS01209
Number of Residues23
DetailsLDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIarkle.CNgenDCgdn.SDErd...C
ChainResidueDetails
BCYS130-CYS152
DCYS79-CYS101
CCYS74-CYS97
GCYS91-CYS113
ECYS78-CYS100
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues216
DetailsDomain: {"description":"TSP type-1 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues223
DetailsDomain: {"description":"LDL-receptor class A","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues180
DetailsDomain: {"description":"EGF-like"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues192
DetailsDomain: {"description":"TSP type-1 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues118
DetailsDomain: {"description":"Sushi 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00302","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues122
DetailsDomain: {"description":"Sushi 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00302","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues102
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues147
DetailsRegion: {"description":"CCP 1"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues77
DetailsRegion: {"description":"CCP 2"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues75
DetailsRegion: {"description":"Factor I module (FIM) 1"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues72
DetailsRegion: {"description":"Factor I module (FIM) 2"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues12
DetailsCompositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues11
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues12
DetailsGlycosylation: {"description":"C-linked (Man) tryptophan","evidences":[{"source":"PubMed","id":"10551839","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues10
DetailsGlycosylation: {"description":"C-linked (Man) tryptophan; partial","evidences":[{"source":"PubMed","id":"10551839","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsGlycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21454577","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3OJY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21454577","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsSite: {"description":"Not glycosylated"}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues106
DetailsDomain: {"description":"TSP type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"4055801","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues7
DetailsTransmembrane: {"description":"Beta stranded","evidences":[{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6H03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H04","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues47
DetailsDomain: {"description":"TSP type-1 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22500023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E0S","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues2
DetailsGlycosylation: {"description":"O-linked (Fuc...) threonine","evidences":[{"source":"PubMed","id":"22267737","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22267737","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues144
DetailsDomain: {"description":"NTR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00295","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues26
DetailsRegion: {"description":"Involved in the tick complement inhibitor CirpT1","evidences":[{"source":"PubMed","id":"31871188","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18536718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21217642","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CU7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KLS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246333

PDB entries from 2025-12-17

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