7NVY

RNA polymerase II pre-initiation complex with closed promoter DNA in proximal position

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000166	molecular_function	nucleotide binding
0	0000439	cellular_component	transcription factor TFIIH core complex
0	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
0	0001666	biological_process	response to hypoxia
0	0001701	biological_process	in utero embryonic development
0	0003676	molecular_function	nucleic acid binding
0	0003677	molecular_function	DNA binding
0	0003678	molecular_function	DNA helicase activity
0	0003684	molecular_function	damaged DNA binding
0	0004386	molecular_function	helicase activity
0	0005515	molecular_function	protein binding
0	0005524	molecular_function	ATP binding
0	0005634	cellular_component	nucleus
0	0005654	cellular_component	nucleoplasm
0	0005669	cellular_component	transcription factor TFIID complex
0	0005675	cellular_component	transcription factor TFIIH holo complex
0	0005737	cellular_component	cytoplasm
0	0005819	cellular_component	spindle
0	0005829	cellular_component	cytosol
0	0006139	biological_process	nucleobase-containing compound metabolic process
0	0006281	biological_process	DNA repair
0	0006283	biological_process	transcription-coupled nucleotide-excision repair
0	0006289	biological_process	nucleotide-excision repair
0	0006351	biological_process	DNA-templated transcription
0	0006357	biological_process	regulation of transcription by RNA polymerase II
0	0006362	biological_process	transcription elongation by RNA polymerase I
0	0006366	biological_process	transcription by RNA polymerase II
0	0006367	biological_process	transcription initiation at RNA polymerase II promoter
0	0006915	biological_process	apoptotic process
0	0006974	biological_process	DNA damage response
0	0006979	biological_process	response to oxidative stress
0	0007059	biological_process	chromosome segregation
0	0008340	biological_process	determination of adult lifespan
0	0009411	biological_process	response to UV
0	0009650	biological_process	UV protection
0	0009791	biological_process	post-embryonic development
0	0016787	molecular_function	hydrolase activity
0	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
0	0016853	molecular_function	isomerase activity
0	0016887	molecular_function	ATP hydrolysis activity
0	0021510	biological_process	spinal cord development
0	0022405	biological_process	hair cycle process
0	0030198	biological_process	extracellular matrix organization
0	0030282	biological_process	bone mineralization
0	0030674	molecular_function	protein-macromolecule adaptor activity
0	0032289	biological_process	central nervous system myelin formation
0	0035264	biological_process	multicellular organism growth
0	0035315	biological_process	hair cell differentiation
0	0040016	biological_process	embryonic cleavage
0	0042274	biological_process	ribosomal small subunit biogenesis
0	0043139	molecular_function	5'-3' DNA helicase activity
0	0043249	biological_process	erythrocyte maturation
0	0043588	biological_process	skin development
0	0045951	biological_process	positive regulation of mitotic recombination
0	0046872	molecular_function	metal ion binding
0	0048009	biological_process	insulin-like growth factor receptor signaling pathway
0	0048568	biological_process	embryonic organ development
0	0048820	biological_process	hair follicle maturation
0	0051536	molecular_function	iron-sulfur cluster binding
0	0051539	molecular_function	4 iron, 4 sulfur cluster binding
0	0060218	biological_process	hematopoietic stem cell differentiation
0	0070516	cellular_component	CAK-ERCC2 complex
0	0071425	biological_process	hematopoietic stem cell proliferation
0	0071817	cellular_component	MMXD complex
0	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
0	1901990	biological_process	regulation of mitotic cell cycle phase transition
1	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
1	0000439	cellular_component	transcription factor TFIIH core complex
1	0003682	molecular_function	chromatin binding
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005675	cellular_component	transcription factor TFIIH holo complex
1	0006281	biological_process	DNA repair
1	0006289	biological_process	nucleotide-excision repair
1	0006351	biological_process	DNA-templated transcription
1	0006360	biological_process	transcription by RNA polymerase I
1	0006366	biological_process	transcription by RNA polymerase II
1	0006367	biological_process	transcription initiation at RNA polymerase II promoter
1	0006974	biological_process	DNA damage response
1	0009755	biological_process	hormone-mediated signaling pathway
1	0045893	biological_process	positive regulation of DNA-templated transcription
1	0046966	molecular_function	nuclear thyroid hormone receptor binding
2	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
2	0000439	cellular_component	transcription factor TFIIH core complex
2	0001671	molecular_function	ATPase activator activity
2	0003690	molecular_function	double-stranded DNA binding
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005669	cellular_component	transcription factor TFIID complex
2	0005675	cellular_component	transcription factor TFIIH holo complex
2	0006281	biological_process	DNA repair
2	0006289	biological_process	nucleotide-excision repair
2	0006366	biological_process	transcription by RNA polymerase II
2	0006974	biological_process	DNA damage response
2	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
2	0016607	cellular_component	nuclear speck
3	0000082	biological_process	G1/S transition of mitotic cell cycle
3	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
3	0000439	cellular_component	transcription factor TFIIH core complex
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005675	cellular_component	transcription factor TFIIH holo complex
3	0006281	biological_process	DNA repair
3	0006289	biological_process	nucleotide-excision repair
3	0006355	biological_process	regulation of DNA-templated transcription
3	0006357	biological_process	regulation of transcription by RNA polymerase II
3	0006367	biological_process	transcription initiation at RNA polymerase II promoter
3	0007512	biological_process	adult heart development
3	0008270	molecular_function	zinc ion binding
3	0021591	biological_process	ventricular system development
3	0043066	biological_process	negative regulation of apoptotic process
3	0045737	biological_process	positive regulation of cyclin-dependent protein serine/threonine kinase activity
3	0046872	molecular_function	metal ion binding
3	0048661	biological_process	positive regulation of smooth muscle cell proliferation
3	0051592	biological_process	response to calcium ion
3	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
3	0070516	cellular_component	CAK-ERCC2 complex
3	0070985	cellular_component	transcription factor TFIIK complex
3	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
4	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
4	0000439	cellular_component	transcription factor TFIIH core complex
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005669	cellular_component	transcription factor TFIID complex
4	0005675	cellular_component	transcription factor TFIIH holo complex
4	0006281	biological_process	DNA repair
4	0006289	biological_process	nucleotide-excision repair
4	0006355	biological_process	regulation of DNA-templated transcription
4	0006366	biological_process	transcription by RNA polymerase II
4	0006974	biological_process	DNA damage response
4	0008270	molecular_function	zinc ion binding
4	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
4	0046872	molecular_function	metal ion binding
4	0097550	cellular_component	transcription preinitiation complex
5	0000439	cellular_component	transcription factor TFIIH core complex
5	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005669	cellular_component	transcription factor TFIID complex
5	0005675	cellular_component	transcription factor TFIIH holo complex
5	0005730	cellular_component	nucleolus
5	0005737	cellular_component	cytoplasm
5	0006281	biological_process	DNA repair
5	0006289	biological_process	nucleotide-excision repair
5	0006294	biological_process	nucleotide-excision repair, preincision complex assembly
5	0006362	biological_process	transcription elongation by RNA polymerase I
5	0006366	biological_process	transcription by RNA polymerase II
5	0006367	biological_process	transcription initiation at RNA polymerase II promoter
5	0006974	biological_process	DNA damage response
5	0071480	biological_process	cellular response to gamma radiation
6	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
6	0000439	cellular_component	transcription factor TFIIH core complex
6	0002031	biological_process	G protein-coupled receptor internalization
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005669	cellular_component	transcription factor TFIID complex
6	0005675	cellular_component	transcription factor TFIIH holo complex
6	0006281	biological_process	DNA repair
6	0006289	biological_process	nucleotide-excision repair
6	0006351	biological_process	DNA-templated transcription
6	0006357	biological_process	regulation of transcription by RNA polymerase II
6	0006366	biological_process	transcription by RNA polymerase II
6	0006367	biological_process	transcription initiation at RNA polymerase II promoter
6	0006974	biological_process	DNA damage response
6	0008270	molecular_function	zinc ion binding
6	0009411	biological_process	response to UV
6	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
6	0016607	cellular_component	nuclear speck
6	0046872	molecular_function	metal ion binding
7	0000112	cellular_component	nucleotide-excision repair factor 3 complex
7	0000166	molecular_function	nucleotide binding
7	0000439	cellular_component	transcription factor TFIIH core complex
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003684	molecular_function	damaged DNA binding
7	0004386	molecular_function	helicase activity
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005669	cellular_component	transcription factor TFIID complex
7	0005675	cellular_component	transcription factor TFIIH holo complex
7	0006265	biological_process	DNA topological change
7	0006281	biological_process	DNA repair
7	0006283	biological_process	transcription-coupled nucleotide-excision repair
7	0006289	biological_process	nucleotide-excision repair
7	0006366	biological_process	transcription by RNA polymerase II
7	0006367	biological_process	transcription initiation at RNA polymerase II promoter
7	0006368	biological_process	transcription elongation by RNA polymerase II
7	0006915	biological_process	apoptotic process
7	0006974	biological_process	DNA damage response
7	0006979	biological_process	response to oxidative stress
7	0008104	biological_process	intracellular protein localization
7	0009411	biological_process	response to UV
7	0009650	biological_process	UV protection
7	0016787	molecular_function	hydrolase activity
7	0016853	molecular_function	isomerase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0035315	biological_process	hair cell differentiation
7	0043065	biological_process	positive regulation of apoptotic process
7	0043138	molecular_function	3'-5' DNA helicase activity
7	0048568	biological_process	embryonic organ development
7	0097550	cellular_component	transcription preinitiation complex
7	1901990	biological_process	regulation of mitotic cell cycle phase transition
7	1990841	molecular_function	promoter-specific chromatin binding
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0001172	biological_process	RNA-templated transcription
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0000781	cellular_component	chromosome, telomeric region
B	0001172	biological_process	RNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005665	cellular_component	RNA polymerase II, core complex
B	0006351	biological_process	DNA-templated transcription
B	0006366	biological_process	transcription by RNA polymerase II
B	0008270	molecular_function	zinc ion binding
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005665	cellular_component	RNA polymerase II, core complex
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006366	biological_process	transcription by RNA polymerase II
C	0046983	molecular_function	protein dimerization activity
D	0000166	molecular_function	nucleotide binding
D	0006352	biological_process	DNA-templated transcription initiation
D	0030880	cellular_component	RNA polymerase complex
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005736	cellular_component	RNA polymerase I complex
E	0006351	biological_process	DNA-templated transcription
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006366	biological_process	transcription by RNA polymerase II
E	0042797	biological_process	tRNA transcription by RNA polymerase III
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001650	cellular_component	fibrillar center
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005736	cellular_component	RNA polymerase I complex
F	0006351	biological_process	DNA-templated transcription
F	0006360	biological_process	transcription by RNA polymerase I
F	0006366	biological_process	transcription by RNA polymerase II
F	0042797	biological_process	tRNA transcription by RNA polymerase III
G	0003676	molecular_function	nucleic acid binding
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0003899	molecular_function	DNA-directed RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005736	cellular_component	RNA polymerase I complex
H	0006351	biological_process	DNA-templated transcription
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed RNA polymerase activity
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed RNA polymerase activity
J	0005634	cellular_component	nucleus
J	0005665	cellular_component	RNA polymerase II, core complex
J	0006351	biological_process	DNA-templated transcription
J	0008270	molecular_function	zinc ion binding
J	0046872	molecular_function	metal ion binding
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0046983	molecular_function	protein dimerization activity
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005730	cellular_component	nucleolus
L	0005736	cellular_component	RNA polymerase I complex
L	0006351	biological_process	DNA-templated transcription
L	0006366	biological_process	transcription by RNA polymerase II
L	0008270	molecular_function	zinc ion binding
L	0046872	molecular_function	metal ion binding
M	0000776	cellular_component	kinetochore
M	0000793	cellular_component	condensed chromosome
M	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
M	0000993	molecular_function	RNA polymerase II complex binding
M	0001174	biological_process	transcriptional start site selection at RNA polymerase II promoter
M	0003677	molecular_function	DNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005669	cellular_component	transcription factor TFIID complex
M	0005694	cellular_component	chromosome
M	0006352	biological_process	DNA-templated transcription initiation
M	0006366	biological_process	transcription by RNA polymerase II
M	0006367	biological_process	transcription initiation at RNA polymerase II promoter
M	0006473	biological_process	protein acetylation
M	0008270	molecular_function	zinc ion binding
M	0010467	biological_process	gene expression
M	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
M	0016407	molecular_function	acetyltransferase activity
M	0016604	cellular_component	nuclear body
M	0016740	molecular_function	transferase activity
M	0016746	molecular_function	acyltransferase activity
M	0017025	molecular_function	TBP-class protein binding
M	0019083	biological_process	viral transcription
M	0032153	cellular_component	cell division site
M	0032993	cellular_component	protein-DNA complex
M	0042585	cellular_component	germinal vesicle
M	0046872	molecular_function	metal ion binding
M	0046966	molecular_function	nuclear thyroid hormone receptor binding
M	0051123	biological_process	RNA polymerase II preinitiation complex assembly
M	0051177	biological_process	meiotic sister chromatid cohesion
M	0051225	biological_process	spindle assembly
M	0051276	biological_process	chromosome organization
M	0061733	molecular_function	protein-lysine-acetyltransferase activity
M	0070897	biological_process	transcription preinitiation complex assembly
M	0090575	cellular_component	RNA polymerase II transcription regulator complex
M	0097550	cellular_component	transcription preinitiation complex
M	0140297	molecular_function	DNA-binding transcription factor binding
M	1904798	biological_process	positive regulation of core promoter binding
M	1990114	biological_process	RNA polymerase II core complex assembly
M	1990841	molecular_function	promoter-specific chromatin binding
O	0000785	cellular_component	chromatin
O	0000791	cellular_component	euchromatin
O	0000976	molecular_function	transcription cis-regulatory region binding
O	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
O	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
O	0000995	molecular_function	RNA polymerase III general transcription initiation factor activity
O	0001046	molecular_function	core promoter sequence-specific DNA binding
O	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
O	0001093	molecular_function	TFIIB-class transcription factor binding
O	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
O	0001188	biological_process	RNA polymerase I preinitiation complex assembly
O	0001673	cellular_component	male germ cell nucleus
O	0001674	cellular_component	female germ cell nucleus
O	0001939	cellular_component	female pronucleus
O	0001940	cellular_component	male pronucleus
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005668	cellular_component	RNA polymerase transcription factor SL1 complex
O	0005669	cellular_component	transcription factor TFIID complex
O	0005672	cellular_component	transcription factor TFIIA complex
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006352	biological_process	DNA-templated transcription initiation
O	0006366	biological_process	transcription by RNA polymerase II
O	0006367	biological_process	transcription initiation at RNA polymerase II promoter
O	0006383	biological_process	transcription by RNA polymerase III
O	0007283	biological_process	spermatogenesis
O	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
O	0017162	molecular_function	aryl hydrocarbon receptor binding
O	0019899	molecular_function	enzyme binding
O	0032991	cellular_component	protein-containing complex
O	0042789	biological_process	mRNA transcription by RNA polymerase II
O	0045120	cellular_component	pronucleus
O	0045893	biological_process	positive regulation of DNA-templated transcription
O	0051123	biological_process	RNA polymerase II preinitiation complex assembly
O	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
O	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
O	0140297	molecular_function	DNA-binding transcription factor binding
Q	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
Q	0001096	molecular_function	TFIIF-class transcription factor complex binding
Q	0003677	molecular_function	DNA binding
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005669	cellular_component	transcription factor TFIID complex
Q	0005674	cellular_component	transcription factor TFIIF complex
Q	0006366	biological_process	transcription by RNA polymerase II
Q	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Q	0006368	biological_process	transcription elongation by RNA polymerase II
Q	0009615	biological_process	response to virus
Q	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
Q	0019211	molecular_function	phosphatase activator activity
Q	0019903	molecular_function	protein phosphatase binding
Q	0019904	molecular_function	protein domain specific binding
Q	0030054	cellular_component	cell junction
Q	0032091	biological_process	negative regulation of protein binding
Q	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Q	0032991	cellular_component	protein-containing complex
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	1990841	molecular_function	promoter-specific chromatin binding
R	0003677	molecular_function	DNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005674	cellular_component	transcription factor TFIIF complex
R	0006366	biological_process	transcription by RNA polymerase II
R	0006367	biological_process	transcription initiation at RNA polymerase II promoter
R	0006368	biological_process	transcription elongation by RNA polymerase II
R	0015630	cellular_component	microtubule cytoskeleton
R	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
R	0016591	cellular_component	RNA polymerase II, holoenzyme
R	0045944	biological_process	positive regulation of transcription by RNA polymerase II
R	0090575	cellular_component	RNA polymerase II transcription regulator complex
U	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
U	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
U	0003677	molecular_function	DNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005669	cellular_component	transcription factor TFIID complex
U	0005672	cellular_component	transcription factor TFIIA complex
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0006366	biological_process	transcription by RNA polymerase II
U	0006367	biological_process	transcription initiation at RNA polymerase II promoter
U	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
U	0017025	molecular_function	TBP-class protein binding
U	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	0046982	molecular_function	protein heterodimerization activity
U	0051123	biological_process	RNA polymerase II preinitiation complex assembly
U	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
U	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
U	0097550	cellular_component	transcription preinitiation complex
V	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005669	cellular_component	transcription factor TFIID complex
V	0005672	cellular_component	transcription factor TFIIA complex
V	0005829	cellular_component	cytosol
V	0006366	biological_process	transcription by RNA polymerase II
V	0006367	biological_process	transcription initiation at RNA polymerase II promoter
V	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
V	0017025	molecular_function	TBP-class protein binding
V	0042803	molecular_function	protein homodimerization activity
V	0045944	biological_process	positive regulation of transcription by RNA polymerase II
V	0046982	molecular_function	protein heterodimerization activity
V	0051123	biological_process	RNA polymerase II preinitiation complex assembly
V	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
V	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005669	cellular_component	transcription factor TFIID complex
W	0005673	cellular_component	transcription factor TFIIE complex
W	0005829	cellular_component	cytosol
W	0006366	biological_process	transcription by RNA polymerase II
W	0006367	biological_process	transcription initiation at RNA polymerase II promoter
W	0008270	molecular_function	zinc ion binding
W	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
W	0046872	molecular_function	metal ion binding
X	0001097	molecular_function	TFIIH-class transcription factor complex binding
X	0003677	molecular_function	DNA binding
X	0003723	molecular_function	RNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005669	cellular_component	transcription factor TFIID complex
X	0005673	cellular_component	transcription factor TFIIE complex
X	0005829	cellular_component	cytosol
X	0006366	biological_process	transcription by RNA polymerase II
X	0006367	biological_process	transcription initiation at RNA polymerase II promoter
X	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI

Chain	Residue	Details
C	ASP136-ILE148

---

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H

Chain	Residue	Details
6	CYS360-HIS380

---

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
A	TYR1593-ALA1599
A	TYR1671-SER1677
A	TYR1678-SER1684
A	TYR1685-SER1691
A	TYR1692-SER1698
A	TYR1699-SER1705
A	TYR1706-SER1712
A	TYR1713-SER1719
A	TYR1720-SER1726
A	TYR1727-SER1733
A	TYR1734-SER1740
A	TYR1615-SER1621
A	TYR1741-ASN1747
A	TYR1748-ASN1754
A	TYR1755-SER1761
A	TYR1762-SER1768
A	TYR1769-ASN1775
A	TYR1776-ASN1782
A	TYR1783-SER1789
A	TYR1790-SER1796
A	TYR1797-SER1803
A	TYR1818-SER1824
A	TYR1622-SER1628
A	TYR1825-SER1831
A	TYR1832-LYS1838
A	TYR1839-SER1845
A	TYR1853-LYS1859
A	TYR1860-LYS1866
A	TYR1867-LYS1873
A	TYR1874-THR1880
A	TYR1888-THR1894
A	TYR1902-LYS1908
A	TYR1909-THR1915
A	TYR1629-ASN1635
A	TYR1916-LYS1922
A	TYR1923-THR1929
A	TYR1930-LYS1936
A	TYR1947-THR1953
A	TYR1636-SER1642
A	TYR1643-SER1649
A	TYR1650-SER1656
A	TYR1657-SER1663
A	TYR1664-SER1670

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
I	TYR112-HIS118

---

site_id	PS00351
Number of Residues	50
Details	TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePRttaLIFsSGKMvctGAKseeqsrlAarkyarvV

Chain	Residue	Details
O	TYR192-VAL241
O	TYR283-LEU332

---

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
C	ASN32-PRO72

---

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW

Chain	Residue	Details
I	CYS86-TRP123

---

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHtLCesCV

Chain	Residue	Details
3	CYS26-VAL35

---

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN

Chain	Residue	Details
0	ALA229-ASN238

---

site_id	PS00782
Number of Residues	16
Details	TFIIB Transcription factor TFIIB repeat signature. GRandAIASACLYIAC

Chain	Residue	Details
M	GLY153-CYS168
M	GLY247-SER262

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
I	PHE16-CYS42

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
E	HIS142-GLU155

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
F	THR58-GLN72

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
K	ILE35-PRO66

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY932-THR944

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	437
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	199
Details	Region: {"description":"Mediates interaction with MMS19"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Motif: {"description":"DEAH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	13
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	44
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	34
Details	Zinc finger: {"description":"C4-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	176
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"A0JN27","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	160
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	Motif: {"description":"DEVH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	53
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	42
Details	Zinc finger: {"description":"TFIIS-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10145","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	152
Details	Repeat: {"description":"1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	153
Details	Repeat: {"description":"2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	4
Details	Region: {"description":"Core promoter DNA-binding","evidences":[{"source":"PubMed","id":"10619841","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	72
Details	Region: {"description":"Necessary for TATA box-bound TBP complex formation","evidences":[{"source":"PubMed","id":"8515820","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8516311","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	3
Details	Region: {"description":"Core promoter DNA-binding","evidences":[{"source":"PubMed","id":"7675079","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	3
Details	Region: {"description":"Core promoter DNA-binding","evidences":[{"source":"PubMed","id":"10619841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7675079","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00469","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11045620","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14641108","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RLY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00469","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11045620","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14641108","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RLY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IYD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"PubMed","id":"12931194","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by TAF1","evidences":[{"source":"PubMed","id":"11278496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	90
Details	Domain: {"description":"HTH TFE/IIEalpha-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00676","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D902","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---