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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7NVW

TFIIH in a pre-translocated state (without ADP-BeF3)

Functional Information from GO Data
ChainGOidnamespacecontents
00000166molecular_functionnucleotide binding
00000439cellular_componenttranscription factor TFIIH core complex
00003676molecular_functionnucleic acid binding
00003677molecular_functionDNA binding
00003678molecular_functionDNA helicase activity
00003684molecular_functiondamaged DNA binding
00004386molecular_functionhelicase activity
00005515molecular_functionprotein binding
00005524molecular_functionATP binding
00005634cellular_componentnucleus
00005654cellular_componentnucleoplasm
00005669cellular_componenttranscription factor TFIID complex
00005675cellular_componenttranscription factor TFIIH holo complex
00005737cellular_componentcytoplasm
00005819cellular_componentspindle
00006139biological_processnucleobase-containing compound metabolic process
00006281biological_processDNA repair
00006283biological_processtranscription-coupled nucleotide-excision repair
00006289biological_processnucleotide-excision repair
00006351biological_processDNA-templated transcription
00006357biological_processregulation of transcription by RNA polymerase II
00006366biological_processtranscription by RNA polymerase II
00006367biological_processtranscription initiation at RNA polymerase II promoter
00006915biological_processapoptotic process
00006974biological_processDNA damage response
00006979biological_processresponse to oxidative stress
00007059biological_processchromosome segregation
00016787molecular_functionhydrolase activity
00016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
00016853molecular_functionisomerase activity
00016887molecular_functionATP hydrolysis activity
00030674molecular_functionprotein-macromolecule adaptor activity
00035315biological_processhair cell differentiation
00043139molecular_function5'-3' DNA helicase activity
00045951biological_processpositive regulation of mitotic recombination
00046872molecular_functionmetal ion binding
00051536molecular_functioniron-sulfur cluster binding
00051539molecular_function4 iron, 4 sulfur cluster binding
00070516cellular_componentCAK-ERCC2 complex
00071817cellular_componentMMXD complex
01901990biological_processregulation of mitotic cell cycle phase transition
10000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
10000439cellular_componenttranscription factor TFIIH core complex
10003682molecular_functionchromatin binding
10005515molecular_functionprotein binding
10005634cellular_componentnucleus
10005654cellular_componentnucleoplasm
10005675cellular_componenttranscription factor TFIIH holo complex
10006281biological_processDNA repair
10006289biological_processnucleotide-excision repair
10006351biological_processDNA-templated transcription
10006360biological_processtranscription by RNA polymerase I
10006366biological_processtranscription by RNA polymerase II
10006367biological_processtranscription initiation at RNA polymerase II promoter
10006974biological_processDNA damage response
10009755biological_processhormone-mediated signaling pathway
10045893biological_processpositive regulation of DNA-templated transcription
10046966molecular_functionnuclear thyroid hormone receptor binding
20000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
20000439cellular_componenttranscription factor TFIIH core complex
20001671molecular_functionATPase activator activity
20003690molecular_functiondouble-stranded DNA binding
20005515molecular_functionprotein binding
20005634cellular_componentnucleus
20005654cellular_componentnucleoplasm
20005669cellular_componenttranscription factor TFIID complex
20005675cellular_componenttranscription factor TFIIH holo complex
20006281biological_processDNA repair
20006289biological_processnucleotide-excision repair
20006351biological_processDNA-templated transcription
20006366biological_processtranscription by RNA polymerase II
20006367biological_processtranscription initiation at RNA polymerase II promoter
20006974biological_processDNA damage response
20016251molecular_functionRNA polymerase II general transcription initiation factor activity
20016607cellular_componentnuclear speck
30000082biological_processG1/S transition of mitotic cell cycle
30000439cellular_componenttranscription factor TFIIH core complex
30005515molecular_functionprotein binding
30005634cellular_componentnucleus
30005654cellular_componentnucleoplasm
30005675cellular_componenttranscription factor TFIIH holo complex
30006281biological_processDNA repair
30006289biological_processnucleotide-excision repair
30006351biological_processDNA-templated transcription
30006357biological_processregulation of transcription by RNA polymerase II
30006367biological_processtranscription initiation at RNA polymerase II promoter
30008270molecular_functionzinc ion binding
30043066biological_processnegative regulation of apoptotic process
30045737biological_processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
30046872molecular_functionmetal ion binding
30048661biological_processpositive regulation of smooth muscle cell proliferation
30061575molecular_functioncyclin-dependent protein serine/threonine kinase activator activity
30070516cellular_componentCAK-ERCC2 complex
30070985cellular_componenttranscription factor TFIIK complex
32000045biological_processregulation of G1/S transition of mitotic cell cycle
40000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
40000439cellular_componenttranscription factor TFIIH core complex
40005515molecular_functionprotein binding
40005634cellular_componentnucleus
40005654cellular_componentnucleoplasm
40005669cellular_componenttranscription factor TFIID complex
40005675cellular_componenttranscription factor TFIIH holo complex
40006281biological_processDNA repair
40006289biological_processnucleotide-excision repair
40006351biological_processDNA-templated transcription
40006355biological_processregulation of DNA-templated transcription
40006366biological_processtranscription by RNA polymerase II
40006367biological_processtranscription initiation at RNA polymerase II promoter
40006974biological_processDNA damage response
40008270molecular_functionzinc ion binding
40016251molecular_functionRNA polymerase II general transcription initiation factor activity
40046872molecular_functionmetal ion binding
40097550cellular_componenttranscription preinitiation complex
50000439cellular_componenttranscription factor TFIIH core complex
50005515molecular_functionprotein binding
50005634cellular_componentnucleus
50005654cellular_componentnucleoplasm
50005669cellular_componenttranscription factor TFIID complex
50005675cellular_componenttranscription factor TFIIH holo complex
50005730cellular_componentnucleolus
50005737cellular_componentcytoplasm
50006281biological_processDNA repair
50006289biological_processnucleotide-excision repair
50006294biological_processnucleotide-excision repair, preincision complex assembly
50006351biological_processDNA-templated transcription
50006366biological_processtranscription by RNA polymerase II
50006367biological_processtranscription initiation at RNA polymerase II promoter
50006974biological_processDNA damage response
60000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
60000439cellular_componenttranscription factor TFIIH core complex
60002031biological_processG protein-coupled receptor internalization
60005515molecular_functionprotein binding
60005634cellular_componentnucleus
60005654cellular_componentnucleoplasm
60005669cellular_componenttranscription factor TFIID complex
60005675cellular_componenttranscription factor TFIIH holo complex
60006281biological_processDNA repair
60006289biological_processnucleotide-excision repair
60006351biological_processDNA-templated transcription
60006357biological_processregulation of transcription by RNA polymerase II
60006366biological_processtranscription by RNA polymerase II
60006367biological_processtranscription initiation at RNA polymerase II promoter
60006974biological_processDNA damage response
60008270molecular_functionzinc ion binding
60009411biological_processresponse to UV
60016251molecular_functionRNA polymerase II general transcription initiation factor activity
60016607cellular_componentnuclear speck
60046872molecular_functionmetal ion binding
70000112cellular_componentnucleotide-excision repair factor 3 complex
70000166molecular_functionnucleotide binding
70000439cellular_componenttranscription factor TFIIH core complex
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003684molecular_functiondamaged DNA binding
70004386molecular_functionhelicase activity
70005515molecular_functionprotein binding
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70005654cellular_componentnucleoplasm
70005669cellular_componenttranscription factor TFIID complex
70005675cellular_componenttranscription factor TFIIH holo complex
70006265biological_processDNA topological change
70006281biological_processDNA repair
70006283biological_processtranscription-coupled nucleotide-excision repair
70006289biological_processnucleotide-excision repair
70006351biological_processDNA-templated transcription
70006366biological_processtranscription by RNA polymerase II
70006367biological_processtranscription initiation at RNA polymerase II promoter
70006368biological_processtranscription elongation by RNA polymerase II
70006915biological_processapoptotic process
70006974biological_processDNA damage response
70006979biological_processresponse to oxidative stress
70008104biological_processintracellular protein localization
70009411biological_processresponse to UV
70016787molecular_functionhydrolase activity
70016853molecular_functionisomerase activity
70016887molecular_functionATP hydrolysis activity
70035315biological_processhair cell differentiation
70043065biological_processpositive regulation of apoptotic process
70043138molecular_function3'-5' DNA helicase activity
70048568biological_processembryonic organ development
70097550cellular_componenttranscription preinitiation complex
71901990biological_processregulation of mitotic cell cycle phase transition
71990841molecular_functionpromoter-specific chromatin binding
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005654cellular_componentnucleoplasm
W0005669cellular_componenttranscription factor TFIID complex
W0005673cellular_componenttranscription factor TFIIE complex
W0006351biological_processDNA-templated transcription
W0006366biological_processtranscription by RNA polymerase II
W0006367biological_processtranscription initiation at RNA polymerase II promoter
W0008270molecular_functionzinc ion binding
W0016251molecular_functionRNA polymerase II general transcription initiation factor activity
W0046872molecular_functionmetal ion binding
W0051123biological_processRNA polymerase II preinitiation complex assembly
Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues21
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H
ChainResidueDetails
6CYS360-HIS380
site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CgHtLCesCV
ChainResidueDetails
3CYS26-VAL35
site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN
ChainResidueDetails
0ALA229-ASN238
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues437
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues199
DetailsRegion: {"description":"Mediates interaction with MMS19"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsMotif: {"description":"DEAH box"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues13
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues44
DetailsZinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues34
DetailsZinc finger: {"description":"C4-type"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues176
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"A0JN27","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues160
DetailsDomain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues3
DetailsMotif: {"description":"DEVH box"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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