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7NVW

TFIIH in a pre-translocated state (without ADP-BeF3)

Functional Information from GO Data
ChainGOidnamespacecontents
00000439cellular_componenttranscription factor TFIIH core complex
00000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
00001666biological_processresponse to hypoxia
00001701biological_processin utero embryonic development
00003676molecular_functionnucleic acid binding
00003677molecular_functionDNA binding
00003678molecular_functionDNA helicase activity
00003684molecular_functiondamaged DNA binding
00004386molecular_functionhelicase activity
00005515molecular_functionprotein binding
00005524molecular_functionATP binding
00005634cellular_componentnucleus
00005654cellular_componentnucleoplasm
00005669cellular_componenttranscription factor TFIID complex
00005675cellular_componenttranscription factor TFIIH holo complex
00005737cellular_componentcytoplasm
00005819cellular_componentspindle
00005829cellular_componentcytosol
00005856cellular_componentcytoskeleton
00006139biological_processnucleobase-containing compound metabolic process
00006259biological_processDNA metabolic process
00006281biological_processDNA repair
00006283biological_processtranscription-coupled nucleotide-excision repair
00006289biological_processnucleotide-excision repair
00006357biological_processregulation of transcription by RNA polymerase II
00006362biological_processtranscription elongation by RNA polymerase I
00006366biological_processtranscription by RNA polymerase II
00006367biological_processtranscription initiation at RNA polymerase II promoter
00006915biological_processapoptotic process
00006974biological_processDNA damage response
00006979biological_processresponse to oxidative stress
00007059biological_processchromosome segregation
00008340biological_processdetermination of adult lifespan
00009411biological_processresponse to UV
00009650biological_processUV protection
00009791biological_processpost-embryonic development
00016787molecular_functionhydrolase activity
00016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
00016853molecular_functionisomerase activity
00016887molecular_functionATP hydrolysis activity
00021510biological_processspinal cord development
00022405biological_processhair cycle process
00030198biological_processextracellular matrix organization
00030282biological_processbone mineralization
00030674molecular_functionprotein-macromolecule adaptor activity
00032289biological_processcentral nervous system myelin formation
00032508biological_processDNA duplex unwinding
00035264biological_processmulticellular organism growth
00035315biological_processhair cell differentiation
00040016biological_processembryonic cleavage
00042274biological_processribosomal small subunit biogenesis
00043139molecular_function5'-3' DNA helicase activity
00043249biological_processerythrocyte maturation
00043588biological_processskin development
00045951biological_processpositive regulation of mitotic recombination
00046872molecular_functionmetal ion binding
00048009biological_processinsulin-like growth factor receptor signaling pathway
00048568biological_processembryonic organ development
00048820biological_processhair follicle maturation
00051539molecular_function4 iron, 4 sulfur cluster binding
00060218biological_processhematopoietic stem cell differentiation
00070516cellular_componentCAK-ERCC2 complex
00071425biological_processhematopoietic stem cell proliferation
00071817cellular_componentMMXD complex
00072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
01901990biological_processregulation of mitotic cell cycle phase transition
10000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
10000439cellular_componenttranscription factor TFIIH core complex
10003682molecular_functionchromatin binding
10005515molecular_functionprotein binding
10005634cellular_componentnucleus
10005654cellular_componentnucleoplasm
10005675cellular_componenttranscription factor TFIIH holo complex
10006281biological_processDNA repair
10006289biological_processnucleotide-excision repair
10006351biological_processDNA-templated transcription
10006360biological_processtranscription by RNA polymerase I
10006366biological_processtranscription by RNA polymerase II
10006367biological_processtranscription initiation at RNA polymerase II promoter
10009755biological_processhormone-mediated signaling pathway
10045893biological_processpositive regulation of DNA-templated transcription
10046966molecular_functionnuclear thyroid hormone receptor binding
20000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
20000439cellular_componenttranscription factor TFIIH core complex
20001671molecular_functionATPase activator activity
20003690molecular_functiondouble-stranded DNA binding
20005515molecular_functionprotein binding
20005634cellular_componentnucleus
20005654cellular_componentnucleoplasm
20005669cellular_componenttranscription factor TFIID complex
20005675cellular_componenttranscription factor TFIIH holo complex
20006281biological_processDNA repair
20006289biological_processnucleotide-excision repair
20006366biological_processtranscription by RNA polymerase II
20016251molecular_functionRNA polymerase II general transcription initiation factor activity
20016607cellular_componentnuclear speck
30000082biological_processG1/S transition of mitotic cell cycle
30000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
30000439cellular_componenttranscription factor TFIIH core complex
30005515molecular_functionprotein binding
30005634cellular_componentnucleus
30005654cellular_componentnucleoplasm
30005675cellular_componenttranscription factor TFIIH holo complex
30006281biological_processDNA repair
30006289biological_processnucleotide-excision repair
30006355biological_processregulation of DNA-templated transcription
30006357biological_processregulation of transcription by RNA polymerase II
30006367biological_processtranscription initiation at RNA polymerase II promoter
30007512biological_processadult heart development
30008270molecular_functionzinc ion binding
30021591biological_processventricular system development
30043066biological_processnegative regulation of apoptotic process
30045737biological_processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
30046872molecular_functionmetal ion binding
30048661biological_processpositive regulation of smooth muscle cell proliferation
30051592biological_processresponse to calcium ion
30061575molecular_functioncyclin-dependent protein serine/threonine kinase activator activity
30070516cellular_componentCAK-ERCC2 complex
30070985cellular_componenttranscription factor TFIIK complex
32000045biological_processregulation of G1/S transition of mitotic cell cycle
40000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
40000439cellular_componenttranscription factor TFIIH core complex
40005515molecular_functionprotein binding
40005634cellular_componentnucleus
40005654cellular_componentnucleoplasm
40005669cellular_componenttranscription factor TFIID complex
40005675cellular_componenttranscription factor TFIIH holo complex
40006281biological_processDNA repair
40006289biological_processnucleotide-excision repair
40006355biological_processregulation of DNA-templated transcription
40006366biological_processtranscription by RNA polymerase II
40016251molecular_functionRNA polymerase II general transcription initiation factor activity
40046872molecular_functionmetal ion binding
40097550cellular_componenttranscription preinitiation complex
50000439cellular_componenttranscription factor TFIIH core complex
50000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
50005515molecular_functionprotein binding
50005634cellular_componentnucleus
50005654cellular_componentnucleoplasm
50005669cellular_componenttranscription factor TFIID complex
50005675cellular_componenttranscription factor TFIIH holo complex
50005730cellular_componentnucleolus
50005737cellular_componentcytoplasm
50006281biological_processDNA repair
50006289biological_processnucleotide-excision repair
50006294biological_processnucleotide-excision repair, preincision complex assembly
50006362biological_processtranscription elongation by RNA polymerase I
50006366biological_processtranscription by RNA polymerase II
50006367biological_processtranscription initiation at RNA polymerase II promoter
50071480biological_processcellular response to gamma radiation
60000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
60000439cellular_componenttranscription factor TFIIH core complex
60002031biological_processG protein-coupled receptor internalization
60005515molecular_functionprotein binding
60005634cellular_componentnucleus
60005654cellular_componentnucleoplasm
60005669cellular_componenttranscription factor TFIID complex
60005675cellular_componenttranscription factor TFIIH holo complex
60006281biological_processDNA repair
60006289biological_processnucleotide-excision repair
60006351biological_processDNA-templated transcription
60006357biological_processregulation of transcription by RNA polymerase II
60006366biological_processtranscription by RNA polymerase II
60006367biological_processtranscription initiation at RNA polymerase II promoter
60008270molecular_functionzinc ion binding
60009411biological_processresponse to UV
60016251molecular_functionRNA polymerase II general transcription initiation factor activity
60016607cellular_componentnuclear speck
60046872molecular_functionmetal ion binding
70000112cellular_componentnucleotide-excision repair factor 3 complex
70000439cellular_componenttranscription factor TFIIH core complex
70000717biological_processnucleotide-excision repair, DNA duplex unwinding
70001666biological_processresponse to hypoxia
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003684molecular_functiondamaged DNA binding
70004386molecular_functionhelicase activity
70005515molecular_functionprotein binding
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70005654cellular_componentnucleoplasm
70005669cellular_componenttranscription factor TFIID complex
70005675cellular_componenttranscription factor TFIIH holo complex
70006265biological_processDNA topological change
70006281biological_processDNA repair
70006283biological_processtranscription-coupled nucleotide-excision repair
70006289biological_processnucleotide-excision repair
70006366biological_processtranscription by RNA polymerase II
70006367biological_processtranscription initiation at RNA polymerase II promoter
70006368biological_processtranscription elongation by RNA polymerase II
70006915biological_processapoptotic process
70006979biological_processresponse to oxidative stress
70008104biological_processprotein localization
70009411biological_processresponse to UV
70009650biological_processUV protection
70016787molecular_functionhydrolase activity
70016853molecular_functionisomerase activity
70016887molecular_functionATP hydrolysis activity
70035315biological_processhair cell differentiation
70043065biological_processpositive regulation of apoptotic process
70043138molecular_function3'-5' DNA helicase activity
70048568biological_processembryonic organ development
70097550cellular_componenttranscription preinitiation complex
71901990biological_processregulation of mitotic cell cycle phase transition
71990841molecular_functionpromoter-specific chromatin binding
W0001113biological_processtranscription open complex formation at RNA polymerase II promoter
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005654cellular_componentnucleoplasm
W0005669cellular_componenttranscription factor TFIID complex
W0005673cellular_componenttranscription factor TFIIE complex
W0005829cellular_componentcytosol
W0006366biological_processtranscription by RNA polymerase II
W0006367biological_processtranscription initiation at RNA polymerase II promoter
W0016251molecular_functionRNA polymerase II general transcription initiation factor activity
W0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues21
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H
ChainResidueDetails
6CYS360-HIS380

site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CgHtLCesCV
ChainResidueDetails
3CYS26-VAL35

site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN
ChainResidueDetails
0ALA229-ASN238

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsZN_FING: C4-type => ECO:0000255
ChainResidueDetails
WCYS129-CYS157

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:27193682, ECO:0007744|PDB:5IY6
ChainResidueDetails
WCYS129
WCYS132
WCYS154
WCYS157

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.3, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
WALA2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
WLYS67

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
WSER268

224004

PDB entries from 2024-08-21

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