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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7NVV

XPB-containing part of TFIIH in a post-translocated state (with ADP-BeF3)

Functional Information from GO Data
ChainGOidnamespacecontents
20000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
20000439cellular_componenttranscription factor TFIIH core complex
20001671molecular_functionATPase activator activity
20003690molecular_functiondouble-stranded DNA binding
20005515molecular_functionprotein binding
20005634cellular_componentnucleus
20005654cellular_componentnucleoplasm
20005669cellular_componenttranscription factor TFIID complex
20005675cellular_componenttranscription factor TFIIH holo complex
20006281biological_processDNA repair
20006289biological_processnucleotide-excision repair
20006366biological_processtranscription by RNA polymerase II
20006974biological_processDNA damage response
20016251molecular_functionRNA polymerase II general transcription initiation factor activity
20016607cellular_componentnuclear speck
50000439cellular_componenttranscription factor TFIIH core complex
50000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
50005515molecular_functionprotein binding
50005634cellular_componentnucleus
50005654cellular_componentnucleoplasm
50005669cellular_componenttranscription factor TFIID complex
50005675cellular_componenttranscription factor TFIIH holo complex
50005730cellular_componentnucleolus
50005737cellular_componentcytoplasm
50006281biological_processDNA repair
50006289biological_processnucleotide-excision repair
50006294biological_processnucleotide-excision repair, preincision complex assembly
50006362biological_processtranscription elongation by RNA polymerase I
50006366biological_processtranscription by RNA polymerase II
50006367biological_processtranscription initiation at RNA polymerase II promoter
50006974biological_processDNA damage response
50071480biological_processcellular response to gamma radiation
70000112cellular_componentnucleotide-excision repair factor 3 complex
70000166molecular_functionnucleotide binding
70000439cellular_componenttranscription factor TFIIH core complex
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003684molecular_functiondamaged DNA binding
70004386molecular_functionhelicase activity
70005515molecular_functionprotein binding
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70005654cellular_componentnucleoplasm
70005669cellular_componenttranscription factor TFIID complex
70005675cellular_componenttranscription factor TFIIH holo complex
70006265biological_processDNA topological change
70006281biological_processDNA repair
70006283biological_processtranscription-coupled nucleotide-excision repair
70006289biological_processnucleotide-excision repair
70006366biological_processtranscription by RNA polymerase II
70006367biological_processtranscription initiation at RNA polymerase II promoter
70006368biological_processtranscription elongation by RNA polymerase II
70006915biological_processapoptotic process
70006974biological_processDNA damage response
70006979biological_processresponse to oxidative stress
70008104biological_processintracellular protein localization
70009411biological_processresponse to UV
70009650biological_processUV protection
70016787molecular_functionhydrolase activity
70016853molecular_functionisomerase activity
70016887molecular_functionATP hydrolysis activity
70035315biological_processhair cell differentiation
70043065biological_processpositive regulation of apoptotic process
70043138molecular_function3'-5' DNA helicase activity
70048568biological_processembryonic organ development
70097550cellular_componenttranscription preinitiation complex
71901990biological_processregulation of mitotic cell cycle phase transition
71990841molecular_functionpromoter-specific chromatin binding
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005654cellular_componentnucleoplasm
W0005669cellular_componenttranscription factor TFIID complex
W0005673cellular_componenttranscription factor TFIIE complex
W0005829cellular_componentcytosol
W0006366biological_processtranscription by RNA polymerase II
W0006367biological_processtranscription initiation at RNA polymerase II promoter
W0008270molecular_functionzinc ion binding
W0016251molecular_functionRNA polymerase II general transcription initiation factor activity
W0046872molecular_functionmetal ion binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues161
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues160
DetailsDomain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsMotif: {"description":"DEVH box"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2025-10-22

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