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7NVV

XPB-containing part of TFIIH in a post-translocated state (with ADP-BeF3)

Functional Information from GO Data
ChainGOidnamespacecontents
20000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
20000439cellular_componenttranscription factor TFIIH core complex
20001671molecular_functionATPase activator activity
20003690molecular_functiondouble-stranded DNA binding
20005515molecular_functionprotein binding
20005634cellular_componentnucleus
20005654cellular_componentnucleoplasm
20005669cellular_componenttranscription factor TFIID complex
20005675cellular_componenttranscription factor TFIIH holo complex
20006281biological_processDNA repair
20006289biological_processnucleotide-excision repair
20006366biological_processtranscription by RNA polymerase II
20016251molecular_functionRNA polymerase II general transcription initiation factor activity
20016607cellular_componentnuclear speck
50000439cellular_componenttranscription factor TFIIH core complex
50000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
50005515molecular_functionprotein binding
50005634cellular_componentnucleus
50005654cellular_componentnucleoplasm
50005669cellular_componenttranscription factor TFIID complex
50005675cellular_componenttranscription factor TFIIH holo complex
50005730cellular_componentnucleolus
50005737cellular_componentcytoplasm
50006281biological_processDNA repair
50006289biological_processnucleotide-excision repair
50006294biological_processnucleotide-excision repair, preincision complex assembly
50006362biological_processtranscription elongation by RNA polymerase I
50006366biological_processtranscription by RNA polymerase II
50006367biological_processtranscription initiation at RNA polymerase II promoter
50071480biological_processcellular response to gamma radiation
70000112cellular_componentnucleotide-excision repair factor 3 complex
70000439cellular_componenttranscription factor TFIIH core complex
70000717biological_processnucleotide-excision repair, DNA duplex unwinding
70001666biological_processresponse to hypoxia
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003684molecular_functiondamaged DNA binding
70004386molecular_functionhelicase activity
70005515molecular_functionprotein binding
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70005654cellular_componentnucleoplasm
70005669cellular_componenttranscription factor TFIID complex
70005675cellular_componenttranscription factor TFIIH holo complex
70006265biological_processDNA topological change
70006281biological_processDNA repair
70006283biological_processtranscription-coupled nucleotide-excision repair
70006289biological_processnucleotide-excision repair
70006366biological_processtranscription by RNA polymerase II
70006367biological_processtranscription initiation at RNA polymerase II promoter
70006368biological_processtranscription elongation by RNA polymerase II
70006915biological_processapoptotic process
70006979biological_processresponse to oxidative stress
70008104biological_processprotein localization
70009411biological_processresponse to UV
70009650biological_processUV protection
70016787molecular_functionhydrolase activity
70016853molecular_functionisomerase activity
70016887molecular_functionATP hydrolysis activity
70035315biological_processhair cell differentiation
70043065biological_processpositive regulation of apoptotic process
70043138molecular_function3'-5' DNA helicase activity
70048568biological_processembryonic organ development
70097550cellular_componenttranscription preinitiation complex
71901990biological_processregulation of mitotic cell cycle phase transition
71990841molecular_functionpromoter-specific chromatin binding
W0001113biological_processtranscription open complex formation at RNA polymerase II promoter
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005654cellular_componentnucleoplasm
W0005669cellular_componenttranscription factor TFIID complex
W0005673cellular_componenttranscription factor TFIIE complex
W0005829cellular_componentcytosol
W0006366biological_processtranscription by RNA polymerase II
W0006367biological_processtranscription initiation at RNA polymerase II promoter
W0016251molecular_functionRNA polymerase II general transcription initiation factor activity
W0046872molecular_functionmetal ion binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsZN_FING: C4-type => ECO:0000255
ChainResidueDetails
WCYS129-CYS157

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:27193682, ECO:0007744|PDB:5IY6
ChainResidueDetails
WCYS129
WCYS132
WCYS154
WCYS157

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.3, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
WALA2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
WLYS67

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
WSER268

224572

PDB entries from 2024-09-04

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