7NVP

Trypanothione reductase from Trypanosoma brucei in complex with N-{4-methoxy-3-[(4-methoxyphenyl)sulfamoyl]phenyl}-5-nitrothiophene-2-carboxamide

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000166	molecular_function	nucleotide binding
AAA	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
AAA	0005654	cellular_component	nucleoplasm
AAA	0005737	cellular_component	cytoplasm
AAA	0015036	molecular_function	disulfide oxidoreductase activity
AAA	0015042	molecular_function	trypanothione-disulfide reductase (NADPH) activity
AAA	0016491	molecular_function	oxidoreductase activity
AAA	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
AAA	0020015	cellular_component	glycosome
AAA	0020023	cellular_component	kinetoplast
AAA	0031981	cellular_component	nuclear lumen
AAA	0045454	biological_process	cell redox homeostasis
AAA	0046872	molecular_function	metal ion binding
AAA	0050660	molecular_function	flavin adenine dinucleotide binding
AAA	0097014	cellular_component	ciliary plasm
AAA	0098869	biological_process	cellular oxidant detoxification
BBB	0000166	molecular_function	nucleotide binding
BBB	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
BBB	0005654	cellular_component	nucleoplasm
BBB	0005737	cellular_component	cytoplasm
BBB	0015036	molecular_function	disulfide oxidoreductase activity
BBB	0015042	molecular_function	trypanothione-disulfide reductase (NADPH) activity
BBB	0016491	molecular_function	oxidoreductase activity
BBB	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
BBB	0020015	cellular_component	glycosome
BBB	0020023	cellular_component	kinetoplast
BBB	0031981	cellular_component	nuclear lumen
BBB	0045454	biological_process	cell redox homeostasis
BBB	0046872	molecular_function	metal ion binding
BBB	0050660	molecular_function	flavin adenine dinucleotide binding
BBB	0097014	cellular_component	ciliary plasm
BBB	0098869	biological_process	cellular oxidant detoxification

Functional Information from PROSITE/UniProt

site_id	PS00076
Number of Residues	11
Details	PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP

Chain	Residue	Details
AAA	GLY49-PRO59

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