7NUJ
Crystal structure of holo-SwHPA-Mg (hydroxy ketone aldolase) from Sphingomonas wittichii RW1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016832 | molecular_function | aldehyde-lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016832 | molecular_function | aldehyde-lyase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"Q47098","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36214476","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2019","firstPage":"2649","lastPage":"2649","volume":"361","journal":"Adv. Synth. Catal.","title":"CH-pi Interactions Promote the Conversion of Hydroxypyruvate in a Class II Pyruvate Aldolase.","authors":["Marsden S.R.","Mestrom L.","Bento I.","Hagedoorn P.L.","McMillan D.G.G.","Hanefeld U."],"citationCrossReferences":[{"database":"DOI","id":"10.1002/adsc.201900205"}]}},{"source":"PDB","id":"6R62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7O5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ADQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36214476","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2019","firstPage":"2649","lastPage":"2649","volume":"361","journal":"Adv. Synth. Catal.","title":"CH-pi Interactions Promote the Conversion of Hydroxypyruvate in a Class II Pyruvate Aldolase.","authors":["Marsden S.R.","Mestrom L.","Bento I.","Hagedoorn P.L.","McMillan D.G.G.","Hanefeld U."],"citationCrossReferences":[{"database":"DOI","id":"10.1002/adsc.201900205"}]}},{"source":"PDB","id":"6R62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NR1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NUJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ADQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"Q47098","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Increases basicity of active site His","evidences":[{"source":"UniProtKB","id":"Q47098","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Improves activity by CH-pi interactions","evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"journal article","publicationDate":"2019","firstPage":"2649","lastPage":"2649","volume":"361","journal":"Adv. Synth. Catal.","title":"CH-pi Interactions Promote the Conversion of Hydroxypyruvate in a Class II Pyruvate Aldolase.","authors":["Marsden S.R.","Mestrom L.","Bento I.","Hagedoorn P.L.","McMillan D.G.G.","Hanefeld U."],"citationCrossReferences":[{"database":"DOI","id":"10.1002/adsc.201900205"}]}}]} |
| Chain | Residue | Details |
