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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7NTF

Cryo-EM structure of unliganded O-GlcNAc transferase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000123cellular_componenthistone acetyltransferase complex
A0000423biological_processmitophagy
A0000432biological_processpositive regulation of transcription from RNA polymerase II promoter by glucose
A0005515molecular_functionprotein binding
A0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006110biological_processregulation of glycolytic process
A0006111biological_processregulation of gluconeogenesis
A0006325biological_processchromatin organization
A0006357biological_processregulation of transcription by RNA polymerase II
A0006486biological_processobsolete protein glycosylation
A0006493biological_processprotein O-linked glycosylation
A0006915biological_processapoptotic process
A0007165biological_processsignal transduction
A0007584biological_processresponse to nutrient
A0008289molecular_functionlipid binding
A0008375molecular_functionacetylglucosaminyltransferase activity
A0016020cellular_componentmembrane
A0016485biological_processprotein processing
A0016740molecular_functiontransferase activity
A0016757molecular_functionglycosyltransferase activity
A0017122cellular_componentprotein N-acetylglucosaminyltransferase complex
A0030097biological_processhemopoiesis
A0030336biological_processnegative regulation of cell migration
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0031397biological_processnegative regulation of protein ubiquitination
A0031490molecular_functionchromatin DNA binding
A0031966cellular_componentmitochondrial membrane
A0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032868biological_processresponse to insulin
A0032922biological_processcircadian regulation of gene expression
A0032991cellular_componentprotein-containing complex
A0035020biological_processregulation of Rac protein signal transduction
A0042995cellular_componentcell projection
A0044545cellular_componentNSL complex
A0045202cellular_componentsynapse
A0045727biological_processpositive regulation of translation
A0045862biological_processpositive regulation of proteolysis
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046626biological_processregulation of insulin receptor signaling pathway
A0048511biological_processrhythmic process
A0051963biological_processregulation of synapse assembly
A0060544biological_processregulation of necroptotic process
A0070822cellular_componentSin3-type complex
A0071333biological_processcellular response to glucose stimulus
A0097363molecular_functionprotein O-acetylglucosaminyltransferase activity
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098978cellular_componentglutamatergic synapse
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0160076biological_processnegative regulation of non-canonical inflammasome complex assembly
A1902455biological_processnegative regulation of stem cell population maintenance
A1902459biological_processpositive regulation of stem cell population maintenance
A1904263biological_processpositive regulation of TORC1 signaling
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000123cellular_componenthistone acetyltransferase complex
B0000423biological_processmitophagy
B0000432biological_processpositive regulation of transcription from RNA polymerase II promoter by glucose
B0005515molecular_functionprotein binding
B0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006110biological_processregulation of glycolytic process
B0006111biological_processregulation of gluconeogenesis
B0006325biological_processchromatin organization
B0006357biological_processregulation of transcription by RNA polymerase II
B0006486biological_processobsolete protein glycosylation
B0006493biological_processprotein O-linked glycosylation
B0006915biological_processapoptotic process
B0007165biological_processsignal transduction
B0007584biological_processresponse to nutrient
B0008289molecular_functionlipid binding
B0008375molecular_functionacetylglucosaminyltransferase activity
B0016020cellular_componentmembrane
B0016485biological_processprotein processing
B0016740molecular_functiontransferase activity
B0016757molecular_functionglycosyltransferase activity
B0017122cellular_componentprotein N-acetylglucosaminyltransferase complex
B0030097biological_processhemopoiesis
B0030336biological_processnegative regulation of cell migration
B0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
B0031397biological_processnegative regulation of protein ubiquitination
B0031490molecular_functionchromatin DNA binding
B0031966cellular_componentmitochondrial membrane
B0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032868biological_processresponse to insulin
B0032922biological_processcircadian regulation of gene expression
B0032991cellular_componentprotein-containing complex
B0035020biological_processregulation of Rac protein signal transduction
B0042995cellular_componentcell projection
B0044545cellular_componentNSL complex
B0045202cellular_componentsynapse
B0045727biological_processpositive regulation of translation
B0045862biological_processpositive regulation of proteolysis
B0045893biological_processpositive regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046626biological_processregulation of insulin receptor signaling pathway
B0048511biological_processrhythmic process
B0051963biological_processregulation of synapse assembly
B0060544biological_processregulation of necroptotic process
B0070822cellular_componentSin3-type complex
B0071333biological_processcellular response to glucose stimulus
B0097363molecular_functionprotein O-acetylglucosaminyltransferase activity
B0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
B0098978cellular_componentglutamatergic synapse
B0120162biological_processpositive regulation of cold-induced thermogenesis
B0160076biological_processnegative regulation of non-canonical inflammasome complex assembly
B1902455biological_processnegative regulation of stem cell population maintenance
B1902459biological_processpositive regulation of stem cell population maintenance
B1904263biological_processpositive regulation of TORC1 signaling
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues33
DetailsRepeat: {"description":"TPR 2"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues33
DetailsRepeat: {"description":"TPR 3"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues33
DetailsRepeat: {"description":"TPR 4"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues66
DetailsRepeat: {"description":"TPR 5"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues66
DetailsRepeat: {"description":"TPR 6"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues66
DetailsRepeat: {"description":"TPR 7"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues66
DetailsRepeat: {"description":"TPR 8"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues66
DetailsRepeat: {"description":"TPR 9"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues66
DetailsRepeat: {"description":"TPR 10"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues66
DetailsRepeat: {"description":"TPR 11"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues66
DetailsRepeat: {"description":"TPR 12"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues20
DetailsRepeat: {"description":"TPR 13; truncated"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues38
DetailsRegion: {"description":"Required for phosphatidylinositol 3,4,5-triphosphate binding","evidences":[{"source":"UniProtKB","id":"P56558","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsMotif: {"description":"DFP motif","evidences":[{"source":"PubMed","id":"27713473","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues32
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"21240259","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26678539","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23103939","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GYW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by AMPK","evidences":[{"source":"PubMed","id":"24563466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37541260","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P56558","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsGlycosylation: {"description":"O-linked (GlcNAc) serine; by autocatalysis","evidences":[{"source":"PubMed","id":"27713473","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2025-12-03

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