7NT3
Crystal structure of SARS CoV2 main protease in complex with FSCU015
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 601 |
| Chain | Residue |
| A | MET6 |
| A | ALA7 |
| A | PHE8 |
| A | GLN127 |
| A | ARG298 |
| A | HOH712 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue DMS B 701 |
| Chain | Residue |
| B | GLY15 |
| B | MET17 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue DMS B 702 |
| Chain | Residue |
| B | ASN84 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue UQZ B 703 |
| Chain | Residue |
| B | HIS41 |
| B | MET49 |
| B | TYR54 |
| B | PHE140 |
| B | LEU141 |
| B | ASN142 |
| B | SER144 |
| B | HIS163 |
| B | HIS164 |
| B | MET165 |
| B | GLU166 |
| B | ASP187 |
| B | ARG188 |
| B | GLN189 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue DMS B 704 |
| Chain | Residue |
| B | TYR37 |
| B | PHE103 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32198291","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile; for 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32198291","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"39223933","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
