7NRY

Re-refinement of MAPKAP kinase-2/inhibitor complex 3fyj

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0004672	molecular_function	protein kinase activity
X	0005524	molecular_function	ATP binding
X	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue B97 X 401

Chain	Residue
X	LEU70
X	ASN191
X	THR206
X	ASP207
X	GLY73
X	ALA91
X	LYS93
X	GLU139
X	CYS140
X	LEU141
X	ASP142
X	GLU190

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site_id	AC2
Number of Residues	1
Details	binding site for residue CL X 402

Chain	Residue
X	LYS93

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site_id	AC3
Number of Residues	5
Details	binding site for residue MLA X 403

Chain	Residue
X	LYS55
X	ASP62
X	ASN83
X	ARG85
X	ARG85

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGLGINGKVLqIfnkrtqek..........FALK

Chain	Residue	Details
X	LEU70-LYS93

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDVKpeNLLY

Chain	Residue	Details
X	ILE182-TYR194

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
X	ASP186

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
X	LYS93
X	LEU70

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
X	GLU139

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784

Chain	Residue	Details
X	THR222

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPK14 => ECO:0000269|PubMed:8846784

Chain	Residue	Details
X	SER272

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250

Chain	Residue	Details
X	SER328

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
X	THR334

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site_id	SWS_FT_FI8
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:21131586

Chain	Residue	Details
X	LYS353

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