7NPJ

Crystal structure of Mycobacterium tuberculosis ArgC in complex with 6-phenoxy-3-pyridinamine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006526	biological_process	arginine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0051287	molecular_function	NAD binding
A	0070401	molecular_function	NADP+ binding
B	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006526	biological_process	arginine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0051287	molecular_function	NAD binding
B	0070401	molecular_function	NADP+ binding
C	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006526	biological_process	arginine biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0051287	molecular_function	NAD binding
C	0070401	molecular_function	NADP+ binding
D	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006526	biological_process	arginine biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0051287	molecular_function	NAD binding
D	0070401	molecular_function	NADP+ binding
E	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0006526	biological_process	arginine biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0051287	molecular_function	NAD binding
E	0070401	molecular_function	NADP+ binding
F	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0006526	biological_process	arginine biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0051287	molecular_function	NAD binding
F	0070401	molecular_function	NADP+ binding
G	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0006526	biological_process	arginine biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0051287	molecular_function	NAD binding
G	0070401	molecular_function	NADP+ binding
H	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0006526	biological_process	arginine biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0051287	molecular_function	NAD binding
H	0070401	molecular_function	NADP+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue UKK B 401

Chain	Residue
B	GLY19
B	TYR20
B	GLY192
B	ARG193
B	THR325

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Functional Information from PROSITE/UniProt

site_id	PS01224
Number of Residues	17
Details	ARGC N-acetyl-gamma-glutamyl-phosphate reductase active site. IAvPGCYPTAallALfP

Chain	Residue	Details
A	ILE153-PRO169

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00150

Chain	Residue	Details
A	CYS158
B	CYS158
C	CYS158
D	CYS158
E	CYS158
F	CYS158
G	CYS158
H	CYS158

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