7NPH

Crystal structure of Mycobacterium tuberculosis ArgC in complex with 5-methoxy-1,3-benzoxazole-2-carboxylic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006526	biological_process	L-arginine biosynthetic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0051287	molecular_function	NAD binding
A	0070401	molecular_function	NADP+ binding
B	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006526	biological_process	L-arginine biosynthetic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0051287	molecular_function	NAD binding
B	0070401	molecular_function	NADP+ binding
C	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006526	biological_process	L-arginine biosynthetic process
C	0008652	biological_process	amino acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0051287	molecular_function	NAD binding
C	0070401	molecular_function	NADP+ binding
D	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006526	biological_process	L-arginine biosynthetic process
D	0008652	biological_process	amino acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0051287	molecular_function	NAD binding
D	0070401	molecular_function	NADP+ binding
E	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0006526	biological_process	L-arginine biosynthetic process
E	0008652	biological_process	amino acid biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0051287	molecular_function	NAD binding
E	0070401	molecular_function	NADP+ binding
F	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0006526	biological_process	L-arginine biosynthetic process
F	0008652	biological_process	amino acid biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0051287	molecular_function	NAD binding
F	0070401	molecular_function	NADP+ binding
G	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0006526	biological_process	L-arginine biosynthetic process
G	0008652	biological_process	amino acid biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0051287	molecular_function	NAD binding
G	0070401	molecular_function	NADP+ binding
H	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0006526	biological_process	L-arginine biosynthetic process
H	0008652	biological_process	amino acid biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0051287	molecular_function	NAD binding
H	0070401	molecular_function	NADP+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue UKE C 401

Chain	Residue
C	GLY19
C	TYR20
C	LEU88
C	CYS109
C	GLY192
C	ARG193
C	PO4402

---

site_id	AC2
Number of Residues	5
Details	binding site for residue PO4 C 402

Chain	Residue
C	CYS158
C	HIS219
C	UKE401
C	ARG114
C	GLY157

---

Functional Information from PROSITE/UniProt

site_id	PS01224
Number of Residues	17
Details	ARGC N-acetyl-gamma-glutamyl-phosphate reductase active site. IAvPGCYPTAallALfP

Chain	Residue	Details
A	ILE153-PRO169

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---