7NP0

Crystal structure of Mycobacterium tuberculosis ArgF in complex with (4-nitrophenyl)boronic acid.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004585	molecular_function	ornithine carbamoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0006591	biological_process	ornithine metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0019240	biological_process	citrulline biosynthetic process
A	0042450	biological_process	L-arginine biosynthetic process via ornithine
B	0004585	molecular_function	ornithine carbamoyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0006591	biological_process	ornithine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0019240	biological_process	citrulline biosynthetic process
B	0042450	biological_process	L-arginine biosynthetic process via ornithine
C	0004585	molecular_function	ornithine carbamoyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0006591	biological_process	ornithine metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0019240	biological_process	citrulline biosynthetic process
C	0042450	biological_process	L-arginine biosynthetic process via ornithine
D	0004585	molecular_function	ornithine carbamoyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006520	biological_process	amino acid metabolic process
D	0006526	biological_process	L-arginine biosynthetic process
D	0006591	biological_process	ornithine metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0019240	biological_process	citrulline biosynthetic process
D	0042450	biological_process	L-arginine biosynthetic process via ornithine
E	0004585	molecular_function	ornithine carbamoyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006520	biological_process	amino acid metabolic process
E	0006526	biological_process	L-arginine biosynthetic process
E	0006591	biological_process	ornithine metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0019240	biological_process	citrulline biosynthetic process
E	0042450	biological_process	L-arginine biosynthetic process via ornithine
F	0004585	molecular_function	ornithine carbamoyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006520	biological_process	amino acid metabolic process
F	0006526	biological_process	L-arginine biosynthetic process
F	0006591	biological_process	ornithine metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0019240	biological_process	citrulline biosynthetic process
F	0042450	biological_process	L-arginine biosynthetic process via ornithine

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue PO4 A 401

Chain	Residue
A	ASN248
A	SER249
A	THR274
A	HOH516
A	HOH517
A	HOH598
A	HOH701

---

site_id	AC2
Number of Residues	9
Details	binding site for residue PO4 A 402

Chain	Residue
A	HOH511
A	HOH512
A	HOH547
A	HOH609
A	HOH631
B	HIS67
C	HIS67
A	HIS67
A	HOH510

---

site_id	AC3
Number of Residues	8
Details	binding site for residue UKH B 401

Chain	Residue
B	ARG52
B	PHE55
B	SER56
B	LEU265
B	ARG292
C	GLU82
C	VAL90
C	TYR94

---

site_id	AC4
Number of Residues	8
Details	binding site for residue PO4 B 402

Chain	Residue
B	ASN49
B	SER50
B	THR51
B	ARG52
B	HOH582
C	SER75
C	THR76
C	HOH506

---

site_id	AC5
Number of Residues	8
Details	binding site for residue UKH C 401

Chain	Residue
A	GLU82
A	VAL90
A	TYR94
C	ARG52
C	PHE55
C	SER56
C	LEU265
C	ARG292

---

site_id	AC6
Number of Residues	4
Details	binding site for residue PO4 C 402

Chain	Residue
C	SER249
C	THR274
C	HOH513
C	HOH528

---

site_id	AC7
Number of Residues	5
Details	binding site for residue PO4 C 403

Chain	Residue
C	SER50
C	HOH502
C	HOH551
C	HOH592
C	HOH660

---

site_id	AC8
Number of Residues	5
Details	binding site for residue PO4 D 501

Chain	Residue
D	ASN248
D	SER249
D	THR274
D	HOH629
D	HOH652

---

site_id	AC9
Number of Residues	8
Details	binding site for residue UKH D 502

Chain	Residue
D	GLU82
D	VAL90
D	TYR94
F	ARG52
F	PHE55
F	SER56
F	LEU265
F	ARG292

---

site_id	AD1
Number of Residues	8
Details	binding site for residue UKH E 401

Chain	Residue
D	ARG52
D	PHE55
D	SER56
D	ARG292
E	GLU82
E	THR87
E	VAL90
E	TYR94

---

site_id	AD2
Number of Residues	5
Details	binding site for residue PO4 E 402

Chain	Residue
E	ASN248
E	SER249
E	THR274
E	HOH514
E	HOH553

---

site_id	AD3
Number of Residues	5
Details	binding site for residue PO4 E 403

Chain	Residue
E	SER50
E	LEU123
E	HOH503
E	HOH562
E	HOH588

---

site_id	AD4
Number of Residues	8
Details	binding site for residue UKH E 404

Chain	Residue
E	ARG52
E	PHE55
E	SER56
E	LEU265
E	ARG292
F	GLU82
F	VAL90
F	TYR94

---

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FdKnSTRT

Chain	Residue	Details
A	PHE46-THR53

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	73
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18062991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2I6U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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