7NOV

Crystal structure of Mycobacterium tuberculosis ArgF in complex with (4-methyl-3-nitrophenyl)boronic acid.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004585	molecular_function	ornithine carbamoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0006591	biological_process	ornithine metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0019240	biological_process	citrulline biosynthetic process
A	0042450	biological_process	L-arginine biosynthetic process via ornithine
B	0004585	molecular_function	ornithine carbamoyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0006591	biological_process	ornithine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0019240	biological_process	citrulline biosynthetic process
B	0042450	biological_process	L-arginine biosynthetic process via ornithine
C	0004585	molecular_function	ornithine carbamoyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0006591	biological_process	ornithine metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0019240	biological_process	citrulline biosynthetic process
C	0042450	biological_process	L-arginine biosynthetic process via ornithine
D	0004585	molecular_function	ornithine carbamoyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006520	biological_process	amino acid metabolic process
D	0006526	biological_process	L-arginine biosynthetic process
D	0006591	biological_process	ornithine metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0019240	biological_process	citrulline biosynthetic process
D	0042450	biological_process	L-arginine biosynthetic process via ornithine
E	0004585	molecular_function	ornithine carbamoyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006520	biological_process	amino acid metabolic process
E	0006526	biological_process	L-arginine biosynthetic process
E	0006591	biological_process	ornithine metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0019240	biological_process	citrulline biosynthetic process
E	0042450	biological_process	L-arginine biosynthetic process via ornithine
F	0004585	molecular_function	ornithine carbamoyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006520	biological_process	amino acid metabolic process
F	0006526	biological_process	L-arginine biosynthetic process
F	0006591	biological_process	ornithine metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0019240	biological_process	citrulline biosynthetic process
F	0042450	biological_process	L-arginine biosynthetic process via ornithine

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue UK2 A 401

Chain	Residue
A	THR87
A	UK2405
A	HOH587
C	ARG52

---

site_id	AC2
Number of Residues	5
Details	binding site for residue PO4 A 402

Chain	Residue
A	ASN248
A	SER249
A	THR274
A	HOH524
A	HOH551

---

site_id	AC3
Number of Residues	6
Details	binding site for residue PO4 A 403

Chain	Residue
A	SER50
A	LEU123
A	HOH503
A	HOH620
A	HOH626
A	HOH716

---

site_id	AC4
Number of Residues	9
Details	binding site for residue PO4 A 404

Chain	Residue
A	HIS67
A	HOH504
A	HOH506
A	HOH526
A	HOH536
A	HOH549
A	HOH581
B	HIS67
C	HIS67

---

site_id	AC5
Number of Residues	9
Details	binding site for residue UK2 A 405

Chain	Residue
A	GLU82
A	VAL90
A	TYR94
A	UK2401
A	HOH599
C	ARG52
C	PHE55
C	LEU265
C	ARG292

---

site_id	AC6
Number of Residues	8
Details	binding site for residue UK2 B 501

Chain	Residue
A	ARG52
A	PHE55
A	LEU265
A	ALA289
A	ARG292
B	GLU82
B	VAL90
B	TYR94

---

site_id	AC7
Number of Residues	6
Details	binding site for residue PO4 B 502

Chain	Residue
B	ASN248
B	SER249
B	ARG250
B	THR274
B	HOH684
E	GLY235

---

site_id	AC8
Number of Residues	7
Details	binding site for residue UK2 C 401

Chain	Residue
B	ARG52
B	LEU265
B	ALA289
B	ARG292
C	GLU82
C	VAL90
C	TYR94

---

site_id	AC9
Number of Residues	6
Details	binding site for residue PO4 C 402

Chain	Residue
C	SER50
C	PRO266
C	HOH504
C	HOH537
C	HOH609
C	HOH611

---

site_id	AD1
Number of Residues	8
Details	binding site for residue UK2 D 401

Chain	Residue
D	ARG52
D	ALA289
D	ARG292
D	HOH520
D	HOH637
E	GLU82
E	VAL90
E	TYR94

---

site_id	AD2
Number of Residues	4
Details	binding site for residue PO4 D 402

Chain	Residue
D	SER249
D	THR274
D	HOH548
D	HOH635

---

site_id	AD3
Number of Residues	4
Details	binding site for residue PO4 D 403

Chain	Residue
D	SER50
D	HOH502
D	HOH560
D	HOH563

---

site_id	AD4
Number of Residues	7
Details	binding site for residue UK2 D 404

Chain	Residue
D	GLU82
D	VAL90
D	TYR94
F	ARG52
F	ALA289
F	ARG292
F	HOH607

---

site_id	AD5
Number of Residues	5
Details	binding site for residue PO4 E 501

Chain	Residue
E	ASN248
E	SER249
E	THR274
E	HOH646
E	HOH653

---

site_id	AD6
Number of Residues	4
Details	binding site for residue PO4 E 502

Chain	Residue
E	SER50
E	LEU123
E	HOH601
E	HOH720

---

site_id	AD7
Number of Residues	8
Details	binding site for residue UK2 F 401

Chain	Residue
F	UK2402
E	ARG52
E	ALA289
E	ARG292
E	HOH692
F	GLU82
F	VAL90
F	TYR94

---

site_id	AD8
Number of Residues	10
Details	binding site for residue UK2 F 402

Chain	Residue
E	ARG52
E	PHE55
E	HOH738
F	ILE45
F	SER75
F	THR76
F	LEU78
F	GLU82
F	THR87
F	UK2401

---

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FdKnSTRT

Chain	Residue	Details
A	PHE46-THR53

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18062991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2I6U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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