Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7NOT

Crystal structure of Mycobacterium tuberculosis ArgC in complex with nicotinamide adenine dinucleotide phosphate (NADP+) and 5-Methoxy-3-indoleacetic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006526	biological_process	L-arginine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0051287	molecular_function	NAD binding
A	0070401	molecular_function	NADP+ binding
B	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006526	biological_process	L-arginine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0051287	molecular_function	NAD binding
B	0070401	molecular_function	NADP+ binding
C	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006526	biological_process	L-arginine biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0051287	molecular_function	NAD binding
C	0070401	molecular_function	NADP+ binding
D	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006526	biological_process	L-arginine biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0051287	molecular_function	NAD binding
D	0070401	molecular_function	NADP+ binding
E	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0006526	biological_process	L-arginine biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0051287	molecular_function	NAD binding
E	0070401	molecular_function	NADP+ binding
F	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0006526	biological_process	L-arginine biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0051287	molecular_function	NAD binding
F	0070401	molecular_function	NADP+ binding
G	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0006526	biological_process	L-arginine biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0051287	molecular_function	NAD binding
G	0070401	molecular_function	NADP+ binding
H	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0006526	biological_process	L-arginine biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0051287	molecular_function	NAD binding
H	0070401	molecular_function	NADP+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue MYI A 401

Chain	Residue
A	CYS158
A	HOH510
A	TYR159
A	SER186
A	GLY187
A	GLY190
A	ALA191
A	TYR211
A	HIS217
A	LEU243

site_id	AC2
Number of Residues	7
Details	binding site for residue MYI B 401

Chain	Residue
B	SER186
B	GLY187
B	GLY190
B	ALA191
B	TYR211
B	HIS217
B	LEU243

site_id	AC3
Number of Residues	24
Details	binding site for residue NAP C 401

Chain	Residue
C	GLY16
C	SER18
C	GLY19
C	TYR20
C	ALA21
C	ALA47
C	ALA48
C	THR49
C	SER50
C	THR73
C	ALA87
C	LEU88
C	PRO89
C	HIS92
C	CYS109
C	GLY110
C	SER189
C	GLY190
C	GLY192
C	ARG193
C	ALA194
C	ASN320
C	GLY324
C	THR325

site_id	AC4
Number of Residues	8
Details	binding site for residue MYI C 402

Chain	Residue
C	TYR159
C	SER186
C	GLY187
C	GLY190
C	ALA191
C	TYR211
C	HIS217
C	LEU243

site_id	AC5
Number of Residues	25
Details	binding site for residue NAP D 401

Chain	Residue
D	GLY16
D	SER18
D	GLY19
D	TYR20
D	ALA21
D	ALA47
D	ALA48
D	THR49
D	SER50
D	THR73
D	ALA87
D	LEU88
D	HIS92
D	CYS109
D	GLY110
D	SER189
D	GLY190
D	GLY192
D	ARG193
D	ALA194
D	ASN320
D	LEU321
D	GLY324
D	THR325
D	HOH514

site_id	AC6
Number of Residues	8
Details	binding site for residue MYI D 402

Chain	Residue
D	SER186
D	GLY187
D	GLY190
D	ALA191
D	TYR211
D	HIS217
D	HIS219
D	LEU243

Functional Information from PROSITE/UniProt

site_id	PS01224
Number of Residues	17
Details	ARGC N-acetyl-gamma-glutamyl-phosphate reductase active site. IAvPGCYPTAallALfP

Chain	Residue	Details
A	ILE153-PRO169

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00150

Chain	Residue	Details
A	CYS158
B	CYS158
C	CYS158
D	CYS158
E	CYS158
F	CYS158
G	CYS158
H	CYS158

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)