7NOR
Crystal structure of Mycobacterium tuberculosis ArgF in complex with 2-fluoro-4-hydroxybenzonitrile.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006526 | biological_process | arginine biosynthetic process |
| A | 0006591 | biological_process | ornithine metabolic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| A | 0019240 | biological_process | citrulline biosynthetic process |
| A | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| B | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006526 | biological_process | arginine biosynthetic process |
| B | 0006591 | biological_process | ornithine metabolic process |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| B | 0019240 | biological_process | citrulline biosynthetic process |
| B | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| C | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006526 | biological_process | arginine biosynthetic process |
| C | 0006591 | biological_process | ornithine metabolic process |
| C | 0016597 | molecular_function | amino acid binding |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| C | 0019240 | biological_process | citrulline biosynthetic process |
| C | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| D | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0006526 | biological_process | arginine biosynthetic process |
| D | 0006591 | biological_process | ornithine metabolic process |
| D | 0016597 | molecular_function | amino acid binding |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| D | 0019240 | biological_process | citrulline biosynthetic process |
| D | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| E | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006520 | biological_process | amino acid metabolic process |
| E | 0006526 | biological_process | arginine biosynthetic process |
| E | 0006591 | biological_process | ornithine metabolic process |
| E | 0016597 | molecular_function | amino acid binding |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| E | 0019240 | biological_process | citrulline biosynthetic process |
| E | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| F | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006520 | biological_process | amino acid metabolic process |
| F | 0006526 | biological_process | arginine biosynthetic process |
| F | 0006591 | biological_process | ornithine metabolic process |
| F | 0016597 | molecular_function | amino acid binding |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| F | 0019240 | biological_process | citrulline biosynthetic process |
| F | 0042450 | biological_process | arginine biosynthetic process via ornithine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 A 401 |
| Chain | Residue |
| A | SER50 |
| A | ARG52 |
| A | THR53 |
| A | HIS128 |
| A | CYS264 |
| A | LEU265 |
| A | ARG292 |
| A | HOH550 |
| A | HOH558 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 402 |
| Chain | Residue |
| A | HIS67 |
| A | HOH543 |
| A | HOH635 |
| B | HIS67 |
| C | HIS67 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 403 |
| Chain | Residue |
| A | ASN248 |
| A | SER249 |
| A | THR274 |
| A | HOH520 |
| A | HOH539 |
| A | HOH546 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 404 |
| Chain | Residue |
| A | THR225 |
| A | TRP226 |
| A | THR227 |
| A | HIS268 |
| A | ASP271 |
| A | GLU272 |
| A | HOH533 |
| B | ASP81 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue 8H8 A 405 |
| Chain | Residue |
| A | VAL71 |
| A | THR76 |
| A | LEU78 |
| A | LEU91 |
| C | THR51 |
| C | ARG52 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue 8H8 A 406 |
| Chain | Residue |
| A | ASN49 |
| A | THR51 |
| A | ARG54 |
| A | PHE55 |
| A | HOH516 |
| B | ILE45 |
| B | VAL71 |
| B | SER75 |
| B | THR76 |
| B | LEU78 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 C 401 |
| Chain | Residue |
| C | SER249 |
| C | THR274 |
| C | HOH509 |
| C | HOH528 |
| C | HOH538 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 C 402 |
| Chain | Residue |
| C | SER50 |
| C | ARG52 |
| C | THR53 |
| C | HIS128 |
| C | LEU265 |
| C | ARG292 |
| C | HOH615 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 D 501 |
| Chain | Residue |
| C | LYS240 |
| D | ASN248 |
| D | SER249 |
| D | THR274 |
| D | ALA276 |
| D | HOH602 |
| D | HOH725 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue 8H8 D 502 |
| Chain | Residue |
| D | LEU78 |
| D | GLU82 |
| D | THR87 |
| D | VAL90 |
| D | LEU91 |
| F | THR51 |
| F | ARG52 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 E 601 |
| Chain | Residue |
| E | SER50 |
| E | THR51 |
| E | ARG52 |
| E | PRO266 |
| E | HOH796 |
| F | PO4501 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 E 602 |
| Chain | Residue |
| E | ASN248 |
| E | SER249 |
| E | THR274 |
| E | HOH731 |
| E | HOH793 |
| site_id | AD4 |
| Number of Residues | 9 |
| Details | binding site for residue 8H8 E 603 |
| Chain | Residue |
| E | THR51 |
| E | ARG52 |
| E | PHE55 |
| E | HOH702 |
| F | THR76 |
| F | LEU78 |
| F | GLU82 |
| F | THR87 |
| F | VAL90 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 F 501 |
| Chain | Residue |
| E | ASN49 |
| E | SER50 |
| E | THR51 |
| E | ARG52 |
| E | PO4601 |
| E | HOH702 |
| F | SER75 |
| F | THR76 |
Functional Information from PROSITE/UniProt
| site_id | PS00097 |
| Number of Residues | 8 |
| Details | CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FdKnSTRT |
| Chain | Residue | Details |
| A | PHE46-THR53 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18062991, ECO:0007744|PDB:2I6U |
| Chain | Residue | Details |
| A | SER50 | |
| B | SER50 | |
| B | GLN77 | |
| B | ARG101 | |
| B | HIS128 | |
| B | ASN160 | |
| B | ASP224 | |
| B | SER228 | |
| B | CYS264 | |
| B | ARG292 | |
| C | SER50 | |
| A | GLN77 | |
| C | GLN77 | |
| C | ARG101 | |
| C | HIS128 | |
| C | ASN160 | |
| C | ASP224 | |
| C | SER228 | |
| C | CYS264 | |
| C | ARG292 | |
| D | SER50 | |
| D | GLN77 | |
| A | ARG101 | |
| D | ARG101 | |
| D | HIS128 | |
| D | ASN160 | |
| D | ASP224 | |
| D | SER228 | |
| D | CYS264 | |
| D | ARG292 | |
| E | SER50 | |
| E | GLN77 | |
| E | ARG101 | |
| A | HIS128 | |
| E | HIS128 | |
| E | ASN160 | |
| E | ASP224 | |
| E | SER228 | |
| E | CYS264 | |
| E | ARG292 | |
| F | SER50 | |
| F | GLN77 | |
| F | ARG101 | |
| F | HIS128 | |
| A | ASN160 | |
| F | ASN160 | |
| F | ASP224 | |
| F | SER228 | |
| F | CYS264 | |
| F | ARG292 | |
| A | ASP224 | |
| A | SER228 | |
| A | CYS264 | |
| A | ARG292 |
