7NOR

Crystal structure of Mycobacterium tuberculosis ArgF in complex with 2-fluoro-4-hydroxybenzonitrile.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004585	molecular_function	ornithine carbamoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0006591	biological_process	ornithine metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0019240	biological_process	citrulline biosynthetic process
A	0042450	biological_process	L-arginine biosynthetic process via ornithine
B	0004585	molecular_function	ornithine carbamoyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0006591	biological_process	ornithine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0019240	biological_process	citrulline biosynthetic process
B	0042450	biological_process	L-arginine biosynthetic process via ornithine
C	0004585	molecular_function	ornithine carbamoyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0006591	biological_process	ornithine metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0019240	biological_process	citrulline biosynthetic process
C	0042450	biological_process	L-arginine biosynthetic process via ornithine
D	0004585	molecular_function	ornithine carbamoyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006520	biological_process	amino acid metabolic process
D	0006526	biological_process	L-arginine biosynthetic process
D	0006591	biological_process	ornithine metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0019240	biological_process	citrulline biosynthetic process
D	0042450	biological_process	L-arginine biosynthetic process via ornithine
E	0004585	molecular_function	ornithine carbamoyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006520	biological_process	amino acid metabolic process
E	0006526	biological_process	L-arginine biosynthetic process
E	0006591	biological_process	ornithine metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0019240	biological_process	citrulline biosynthetic process
E	0042450	biological_process	L-arginine biosynthetic process via ornithine
F	0004585	molecular_function	ornithine carbamoyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006520	biological_process	amino acid metabolic process
F	0006526	biological_process	L-arginine biosynthetic process
F	0006591	biological_process	ornithine metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0019240	biological_process	citrulline biosynthetic process
F	0042450	biological_process	L-arginine biosynthetic process via ornithine

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue PO4 A 401

Chain	Residue
A	SER50
A	ARG52
A	THR53
A	HIS128
A	CYS264
A	LEU265
A	ARG292
A	HOH550
A	HOH558

---

site_id	AC2
Number of Residues	5
Details	binding site for residue PO4 A 402

Chain	Residue
A	HIS67
A	HOH543
A	HOH635
B	HIS67
C	HIS67

---

site_id	AC3
Number of Residues	6
Details	binding site for residue PO4 A 403

Chain	Residue
A	ASN248
A	SER249
A	THR274
A	HOH520
A	HOH539
A	HOH546

---

site_id	AC4
Number of Residues	8
Details	binding site for residue PO4 A 404

Chain	Residue
A	THR225
A	TRP226
A	THR227
A	HIS268
A	ASP271
A	GLU272
A	HOH533
B	ASP81

---

site_id	AC5
Number of Residues	6
Details	binding site for residue 8H8 A 405

Chain	Residue
A	VAL71
A	THR76
A	LEU78
A	LEU91
C	THR51
C	ARG52

---

site_id	AC6
Number of Residues	10
Details	binding site for residue 8H8 A 406

Chain	Residue
A	ASN49
A	THR51
A	ARG54
A	PHE55
A	HOH516
B	ILE45
B	VAL71
B	SER75
B	THR76
B	LEU78

---

site_id	AC7
Number of Residues	5
Details	binding site for residue PO4 C 401

Chain	Residue
C	SER249
C	THR274
C	HOH509
C	HOH528
C	HOH538

---

site_id	AC8
Number of Residues	7
Details	binding site for residue PO4 C 402

Chain	Residue
C	SER50
C	ARG52
C	THR53
C	HIS128
C	LEU265
C	ARG292
C	HOH615

---

site_id	AC9
Number of Residues	7
Details	binding site for residue PO4 D 501

Chain	Residue
C	LYS240
D	ASN248
D	SER249
D	THR274
D	ALA276
D	HOH602
D	HOH725

---

site_id	AD1
Number of Residues	7
Details	binding site for residue 8H8 D 502

Chain	Residue
D	LEU78
D	GLU82
D	THR87
D	VAL90
D	LEU91
F	THR51
F	ARG52

---

site_id	AD2
Number of Residues	6
Details	binding site for residue PO4 E 601

Chain	Residue
E	SER50
E	THR51
E	ARG52
E	PRO266
E	HOH796
F	PO4501

---

site_id	AD3
Number of Residues	5
Details	binding site for residue PO4 E 602

Chain	Residue
E	ASN248
E	SER249
E	THR274
E	HOH731
E	HOH793

---

site_id	AD4
Number of Residues	9
Details	binding site for residue 8H8 E 603

Chain	Residue
E	THR51
E	ARG52
E	PHE55
E	HOH702
F	THR76
F	LEU78
F	GLU82
F	THR87
F	VAL90

---

site_id	AD5
Number of Residues	8
Details	binding site for residue PO4 F 501

Chain	Residue
E	ASN49
E	SER50
E	THR51
E	ARG52
E	PO4601
E	HOH702
F	SER75
F	THR76

---

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FdKnSTRT

Chain	Residue	Details
A	PHE46-THR53

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	74
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18062991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2I6U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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