7NNZ

Crystal structure of Mycobacterium tuberculosis ArgF in complex with 5-methyl-4-phenylthiazol-2-amine.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004585	molecular_function	ornithine carbamoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0006591	biological_process	ornithine metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0019240	biological_process	citrulline biosynthetic process
A	0042450	biological_process	L-arginine biosynthetic process via ornithine
B	0004585	molecular_function	ornithine carbamoyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0006591	biological_process	ornithine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0019240	biological_process	citrulline biosynthetic process
B	0042450	biological_process	L-arginine biosynthetic process via ornithine
C	0004585	molecular_function	ornithine carbamoyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0006591	biological_process	ornithine metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0019240	biological_process	citrulline biosynthetic process
C	0042450	biological_process	L-arginine biosynthetic process via ornithine
D	0004585	molecular_function	ornithine carbamoyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006520	biological_process	amino acid metabolic process
D	0006526	biological_process	L-arginine biosynthetic process
D	0006591	biological_process	ornithine metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0019240	biological_process	citrulline biosynthetic process
D	0042450	biological_process	L-arginine biosynthetic process via ornithine
E	0004585	molecular_function	ornithine carbamoyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006520	biological_process	amino acid metabolic process
E	0006526	biological_process	L-arginine biosynthetic process
E	0006591	biological_process	ornithine metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0019240	biological_process	citrulline biosynthetic process
E	0042450	biological_process	L-arginine biosynthetic process via ornithine
F	0004585	molecular_function	ornithine carbamoyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006520	biological_process	amino acid metabolic process
F	0006526	biological_process	L-arginine biosynthetic process
F	0006591	biological_process	ornithine metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0019240	biological_process	citrulline biosynthetic process
F	0042450	biological_process	L-arginine biosynthetic process via ornithine

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue PO4 A 401

Chain	Residue
A	SER50
A	ARG52
A	THR53
A	HIS128
A	CYS264
A	LEU265
A	ARG292
A	HOH709

---

site_id	AC2
Number of Residues	6
Details	binding site for residue PO4 A 402

Chain	Residue
A	SER249
A	THR274
A	HOH560
A	HOH579
A	HOH640
A	ASN248

---

site_id	AC3
Number of Residues	6
Details	binding site for residue PTZ A 403

Chain	Residue
A	THR76
A	THR87
A	VAL90
A	LEU91
C	ARG52
C	PHE55

---

site_id	AC4
Number of Residues	5
Details	binding site for residue PO4 C 401

Chain	Residue
C	SER249
C	THR274
C	HOH512
C	HOH519
C	HOH522

---

site_id	AC5
Number of Residues	8
Details	binding site for residue PTZ C 402

Chain	Residue
B	THR51
B	ARG52
B	HOH499
C	THR76
C	LEU78
C	GLU82
C	VAL90
C	LEU91

---

site_id	AC6
Number of Residues	6
Details	binding site for residue PTZ D 401

Chain	Residue
D	ILE45
D	THR76
D	LEU78
D	LEU91
F	THR51
F	ARG52

---

site_id	AC7
Number of Residues	7
Details	binding site for residue PO4 D 402

Chain	Residue
D	SER50
D	THR51
D	ARG52
D	PO4404
D	HOH512
D	HOH538
E	PTZ501

---

site_id	AC8
Number of Residues	7
Details	binding site for residue PO4 D 403

Chain	Residue
C	LYS240
D	ASN248
D	SER249
D	THR274
D	HOH505
D	HOH620
D	HOH657

---

site_id	AC9
Number of Residues	4
Details	binding site for residue PO4 D 404

Chain	Residue
D	SER50
D	ARG52
D	PO4402
D	HOH546

---

site_id	AD1
Number of Residues	7
Details	binding site for residue PTZ E 501

Chain	Residue
D	THR51
D	PHE55
D	PO4402
E	ILE45
E	THR76
E	VAL90
E	LEU91

---

site_id	AD2
Number of Residues	6
Details	binding site for residue PO4 E 502

Chain	Residue
E	ASN248
E	SER249
E	THR274
E	HOH616
E	HOH683
E	HOH794

---

site_id	AD3
Number of Residues	7
Details	binding site for residue PO4 E 503

Chain	Residue
E	THR51
E	ARG52
E	HOH625
E	HOH631
F	ASP81
F	PO4501
F	PTZ502

---

site_id	AD4
Number of Residues	10
Details	binding site for residue PO4 F 501

Chain	Residue
E	ASN49
E	SER50
E	THR51
E	PO4503
F	SER75
F	THR76
F	PTZ502
F	HOH633
F	HOH648
F	HOH650

---

site_id	AD5
Number of Residues	7
Details	binding site for residue PTZ F 502

Chain	Residue
E	THR51
E	ARG52
E	PHE55
E	PO4503
F	ILE45
F	THR76
F	PO4501

---

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FdKnSTRT

Chain	Residue	Details
A	PHE46-THR53

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	74
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18062991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2I6U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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