7NNZ
Crystal structure of Mycobacterium tuberculosis ArgF in complex with 5-methyl-4-phenylthiazol-2-amine.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006526 | biological_process | arginine biosynthetic process |
| A | 0006591 | biological_process | ornithine metabolic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| A | 0019240 | biological_process | citrulline biosynthetic process |
| A | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| B | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006526 | biological_process | arginine biosynthetic process |
| B | 0006591 | biological_process | ornithine metabolic process |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| B | 0019240 | biological_process | citrulline biosynthetic process |
| B | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| C | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006526 | biological_process | arginine biosynthetic process |
| C | 0006591 | biological_process | ornithine metabolic process |
| C | 0016597 | molecular_function | amino acid binding |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| C | 0019240 | biological_process | citrulline biosynthetic process |
| C | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| D | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0006526 | biological_process | arginine biosynthetic process |
| D | 0006591 | biological_process | ornithine metabolic process |
| D | 0016597 | molecular_function | amino acid binding |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| D | 0019240 | biological_process | citrulline biosynthetic process |
| D | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| E | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006520 | biological_process | amino acid metabolic process |
| E | 0006526 | biological_process | arginine biosynthetic process |
| E | 0006591 | biological_process | ornithine metabolic process |
| E | 0016597 | molecular_function | amino acid binding |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| E | 0019240 | biological_process | citrulline biosynthetic process |
| E | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| F | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006520 | biological_process | amino acid metabolic process |
| F | 0006526 | biological_process | arginine biosynthetic process |
| F | 0006591 | biological_process | ornithine metabolic process |
| F | 0016597 | molecular_function | amino acid binding |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| F | 0019240 | biological_process | citrulline biosynthetic process |
| F | 0042450 | biological_process | arginine biosynthetic process via ornithine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 401 |
| Chain | Residue |
| A | SER50 |
| A | ARG52 |
| A | THR53 |
| A | HIS128 |
| A | CYS264 |
| A | LEU265 |
| A | ARG292 |
| A | HOH709 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 402 |
| Chain | Residue |
| A | SER249 |
| A | THR274 |
| A | HOH560 |
| A | HOH579 |
| A | HOH640 |
| A | ASN248 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PTZ A 403 |
| Chain | Residue |
| A | THR76 |
| A | THR87 |
| A | VAL90 |
| A | LEU91 |
| C | ARG52 |
| C | PHE55 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 C 401 |
| Chain | Residue |
| C | SER249 |
| C | THR274 |
| C | HOH512 |
| C | HOH519 |
| C | HOH522 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue PTZ C 402 |
| Chain | Residue |
| B | THR51 |
| B | ARG52 |
| B | HOH499 |
| C | THR76 |
| C | LEU78 |
| C | GLU82 |
| C | VAL90 |
| C | LEU91 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue PTZ D 401 |
| Chain | Residue |
| D | ILE45 |
| D | THR76 |
| D | LEU78 |
| D | LEU91 |
| F | THR51 |
| F | ARG52 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 D 402 |
| Chain | Residue |
| D | SER50 |
| D | THR51 |
| D | ARG52 |
| D | PO4404 |
| D | HOH512 |
| D | HOH538 |
| E | PTZ501 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 D 403 |
| Chain | Residue |
| C | LYS240 |
| D | ASN248 |
| D | SER249 |
| D | THR274 |
| D | HOH505 |
| D | HOH620 |
| D | HOH657 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 D 404 |
| Chain | Residue |
| D | SER50 |
| D | ARG52 |
| D | PO4402 |
| D | HOH546 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue PTZ E 501 |
| Chain | Residue |
| D | THR51 |
| D | PHE55 |
| D | PO4402 |
| E | ILE45 |
| E | THR76 |
| E | VAL90 |
| E | LEU91 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 E 502 |
| Chain | Residue |
| E | ASN248 |
| E | SER249 |
| E | THR274 |
| E | HOH616 |
| E | HOH683 |
| E | HOH794 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 E 503 |
| Chain | Residue |
| E | THR51 |
| E | ARG52 |
| E | HOH625 |
| E | HOH631 |
| F | ASP81 |
| F | PO4501 |
| F | PTZ502 |
| site_id | AD4 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 F 501 |
| Chain | Residue |
| E | ASN49 |
| E | SER50 |
| E | THR51 |
| E | PO4503 |
| F | SER75 |
| F | THR76 |
| F | PTZ502 |
| F | HOH633 |
| F | HOH648 |
| F | HOH650 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue PTZ F 502 |
| Chain | Residue |
| E | THR51 |
| E | ARG52 |
| E | PHE55 |
| E | PO4503 |
| F | ILE45 |
| F | THR76 |
| F | PO4501 |
Functional Information from PROSITE/UniProt
| site_id | PS00097 |
| Number of Residues | 8 |
| Details | CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FdKnSTRT |
| Chain | Residue | Details |
| A | PHE46-THR53 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18062991, ECO:0007744|PDB:2I6U |
| Chain | Residue | Details |
| A | SER50 | |
| B | SER50 | |
| B | GLN77 | |
| B | ARG101 | |
| B | HIS128 | |
| B | ASN160 | |
| B | ASP224 | |
| B | SER228 | |
| B | CYS264 | |
| B | ARG292 | |
| C | SER50 | |
| A | GLN77 | |
| C | GLN77 | |
| C | ARG101 | |
| C | HIS128 | |
| C | ASN160 | |
| C | ASP224 | |
| C | SER228 | |
| C | CYS264 | |
| C | ARG292 | |
| D | SER50 | |
| D | GLN77 | |
| A | ARG101 | |
| D | ARG101 | |
| D | HIS128 | |
| D | ASN160 | |
| D | ASP224 | |
| D | SER228 | |
| D | CYS264 | |
| D | ARG292 | |
| E | SER50 | |
| E | GLN77 | |
| E | ARG101 | |
| A | HIS128 | |
| E | HIS128 | |
| E | ASN160 | |
| E | ASP224 | |
| E | SER228 | |
| E | CYS264 | |
| E | ARG292 | |
| F | SER50 | |
| F | GLN77 | |
| F | ARG101 | |
| F | HIS128 | |
| A | ASN160 | |
| F | ASN160 | |
| F | ASP224 | |
| F | SER228 | |
| F | CYS264 | |
| F | ARG292 | |
| A | ASP224 | |
| A | SER228 | |
| A | CYS264 | |
| A | ARG292 |
