Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7NNY

Crystal structure of Mycobacterium tuberculosis ArgF in complex with naphthalen-1-ol.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004585	molecular_function	ornithine carbamoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0006591	biological_process	ornithine metabolic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0019240	biological_process	citrulline biosynthetic process
A	0042450	biological_process	arginine biosynthetic process via ornithine
B	0004585	molecular_function	ornithine carbamoyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0006591	biological_process	ornithine metabolic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0019240	biological_process	citrulline biosynthetic process
B	0042450	biological_process	arginine biosynthetic process via ornithine
C	0004585	molecular_function	ornithine carbamoyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0006591	biological_process	ornithine metabolic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0019240	biological_process	citrulline biosynthetic process
C	0042450	biological_process	arginine biosynthetic process via ornithine
D	0004585	molecular_function	ornithine carbamoyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006520	biological_process	amino acid metabolic process
D	0006526	biological_process	L-arginine biosynthetic process
D	0006591	biological_process	ornithine metabolic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0019240	biological_process	citrulline biosynthetic process
D	0042450	biological_process	arginine biosynthetic process via ornithine
E	0004585	molecular_function	ornithine carbamoyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006520	biological_process	amino acid metabolic process
E	0006526	biological_process	L-arginine biosynthetic process
E	0006591	biological_process	ornithine metabolic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0019240	biological_process	citrulline biosynthetic process
E	0042450	biological_process	arginine biosynthetic process via ornithine
F	0004585	molecular_function	ornithine carbamoyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006520	biological_process	amino acid metabolic process
F	0006526	biological_process	L-arginine biosynthetic process
F	0006591	biological_process	ornithine metabolic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0019240	biological_process	citrulline biosynthetic process
F	0042450	biological_process	arginine biosynthetic process via ornithine

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue PO4 A 601

Chain	Residue
A	ASN248
A	SER249
A	THR274
A	HOH720
A	HOH793
A	HOH815

site_id	AC2
Number of Residues	8
Details	binding site for residue PO4 A 602

Chain	Residue
A	1NP603
C	SER50
C	THR51
C	ARG52
C	HOH834
A	SER75
A	THR76
A	ASP81

site_id	AC3
Number of Residues	5
Details	binding site for residue 1NP A 603

Chain	Residue
A	THR76
A	LEU78
A	PO4602
A	1NP604
C	ARG52

site_id	AC4
Number of Residues	6
Details	binding site for residue 1NP A 604

Chain	Residue
A	GLU82
A	VAL90
A	TYR94
A	1NP603
C	ARG52
C	LEU265

site_id	AC5
Number of Residues	6
Details	binding site for residue 1NP A 605

Chain	Residue
A	ARG52
A	LEU265
B	GLU82
B	VAL90
B	TYR94
B	1NP602

site_id	AC6
Number of Residues	9
Details	binding site for residue PO4 A 606

Chain	Residue
A	HIS67
A	HOH701
A	HOH705
A	HOH726
A	HOH728
A	HOH750
A	HOH779
B	HIS67
C	HIS67

site_id	AC7
Number of Residues	6
Details	binding site for residue PO4 B 601

Chain	Residue
B	ASN248
B	SER249
B	ARG250
B	THR274
B	HOH710
E	GLY235

site_id	AC8
Number of Residues	7
Details	binding site for residue 1NP B 602

Chain	Residue
A	THR51
A	ARG52
A	PHE55
A	1NP605
B	THR76
B	GLN77
B	LEU78

site_id	AC9
Number of Residues	5
Details	binding site for residue PO4 C 601

Chain	Residue
C	ASN248
C	SER249
C	THR274
C	HOH723
C	HOH750

site_id	AD1
Number of Residues	9
Details	binding site for residue PO4 C 602

Chain	Residue
B	SER50
B	THR51
B	ARG52
B	HOH777
C	SER75
C	THR76
C	ASP81
C	1NP604
C	HOH809

site_id	AD2
Number of Residues	5
Details	binding site for residue 1NP C 603

Chain	Residue
B	ARG52
C	GLU82
C	VAL90
C	TYR94
C	1NP604

site_id	AD3
Number of Residues	5
Details	binding site for residue 1NP C 604

Chain	Residue
B	ARG52
C	THR76
C	LEU78
C	PO4602
C	1NP603

site_id	AD4
Number of Residues	6
Details	binding site for residue PO4 D 601

Chain	Residue
D	ASN248
D	SER249
D	THR274
D	ALA276
D	HOH744
D	HOH800

site_id	AD5
Number of Residues	5
Details	binding site for residue PO4 D 602

Chain	Residue
D	SER75
D	THR76
D	ASP81
F	SER50
F	THR51

site_id	AD6
Number of Residues	6
Details	binding site for residue 1NP D 603

Chain	Residue
D	GLU82
D	VAL90
D	TYR94
D	1NP604
F	ARG52
F	LEU265

site_id	AD7
Number of Residues	6
Details	binding site for residue 1NP D 604

Chain	Residue
F	ARG52
D	VAL71
D	THR76
D	LEU78
D	1NP603
F	THR51

site_id	AD8
Number of Residues	5
Details	binding site for residue PO4 E 501

Chain	Residue
E	ASN248
E	SER249
E	THR274
E	HOH659
E	HOH661

site_id	AD9
Number of Residues	6
Details	binding site for residue PO4 E 502

Chain	Residue
E	SER50
E	THR51
E	ARG52
E	PRO266
E	PO4503
E	HOH606

site_id	AE1
Number of Residues	6
Details	binding site for residue PO4 E 503

Chain	Residue
E	SER50
E	THR51
E	PO4502
E	HOH711
F	SER75
F	THR76

site_id	AE2
Number of Residues	5
Details	binding site for residue 1NP E 504

Chain	Residue
D	ARG52
E	GLU82
E	VAL90
E	TYR94
E	1NP505

site_id	AE3
Number of Residues	6
Details	binding site for residue 1NP E 505

Chain	Residue
D	PHE55
E	ILE45
E	VAL71
E	THR76
E	LEU78
E	1NP504

site_id	AE4
Number of Residues	5
Details	binding site for residue 1NP F 401

Chain	Residue
E	ARG52
F	GLU82
F	VAL90
F	TYR94
F	1NP402

site_id	AE5
Number of Residues	6
Details	binding site for residue 1NP F 402

Chain	Residue
E	THR51
E	ARG52
F	ILE45
F	THR76
F	LEU78
F	1NP401

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FdKnSTRT

Chain	Residue	Details
A	PHE46-THR53

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	54
Details	BINDING: BINDING => ECO:0000269\|PubMed:18062991, ECO:0007744\|PDB:2I6U

Chain	Residue	Details
A	SER50
B	SER50
B	GLN77
B	ARG101
B	HIS128
B	ASN160
B	ASP224
B	SER228
B	CYS264
B	ARG292
C	SER50
A	GLN77
C	GLN77
C	ARG101
C	HIS128
C	ASN160
C	ASP224
C	SER228
C	CYS264
C	ARG292
D	SER50
D	GLN77
A	ARG101
D	ARG101
D	HIS128
D	ASN160
D	ASP224
D	SER228
D	CYS264
D	ARG292
E	SER50
E	GLN77
E	ARG101
A	HIS128
E	HIS128
E	ASN160
E	ASP224
E	SER228
E	CYS264
E	ARG292
F	SER50
F	GLN77
F	ARG101
F	HIS128
A	ASN160
F	ASN160
F	ASP224
F	SER228
F	CYS264
F	ARG292
A	ASP224
A	SER228
A	CYS264
A	ARG292

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)