7NNR
Crystal structure of Mycobacterium tuberculosis ArgC in complex with xanthene-9-carboxylic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003942 | molecular_function | N-acetyl-gamma-glutamyl-phosphate reductase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006526 | biological_process | arginine biosynthetic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070401 | molecular_function | NADP+ binding |
| B | 0003942 | molecular_function | N-acetyl-gamma-glutamyl-phosphate reductase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006526 | biological_process | arginine biosynthetic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0046983 | molecular_function | protein dimerization activity |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue UJQ A 401 |
| Chain | Residue |
| A | HIS90 |
| A | TYR159 |
| A | SER186 |
| A | GLY187 |
| A | GLY190 |
| A | ALA191 |
| A | TYR211 |
| A | HIS217 |
| A | LEU243 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue BTB A 402 |
| Chain | Residue |
| A | HIS32 |
| A | ALA34 |
| A | ASP37 |
| A | ARG39 |
| A | TRP339 |
| A | PRO340 |
| A | ASP343 |
| A | HOH716 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue UJQ B 401 |
| Chain | Residue |
| B | HIS90 |
| B | TYR159 |
| B | SER186 |
| B | GLY187 |
| B | GLY190 |
| B | ALA191 |
| B | TYR211 |
| B | HIS217 |
| B | LEU243 |
| B | HOH659 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue BTB B 402 |
| Chain | Residue |
| B | HIS32 |
| B | ALA34 |
| B | ASP37 |
| B | ARG39 |
| B | TRP339 |
| B | PRO340 |
| B | ASP343 |
| B | HOH650 |
Functional Information from PROSITE/UniProt
| site_id | PS01224 |
| Number of Residues | 17 |
| Details | ARGC N-acetyl-gamma-glutamyl-phosphate reductase active site. IAvPGCYPTAallALfP |
| Chain | Residue | Details |
| A | ILE153-PRO169 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00150 |
| Chain | Residue | Details |
| B | CYS158 | |
| A | CYS158 |
