7NNF

Crystal structure of Mycobacterium tuberculosis ArgF in apo form.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004585	molecular_function	ornithine carbamoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0006591	biological_process	ornithine metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0019240	biological_process	citrulline biosynthetic process
A	0042450	biological_process	L-arginine biosynthetic process via ornithine
B	0004585	molecular_function	ornithine carbamoyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0006591	biological_process	ornithine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0019240	biological_process	citrulline biosynthetic process
B	0042450	biological_process	L-arginine biosynthetic process via ornithine
C	0004585	molecular_function	ornithine carbamoyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0006591	biological_process	ornithine metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0019240	biological_process	citrulline biosynthetic process
C	0042450	biological_process	L-arginine biosynthetic process via ornithine
D	0004585	molecular_function	ornithine carbamoyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006520	biological_process	amino acid metabolic process
D	0006526	biological_process	L-arginine biosynthetic process
D	0006591	biological_process	ornithine metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0019240	biological_process	citrulline biosynthetic process
D	0042450	biological_process	L-arginine biosynthetic process via ornithine
E	0004585	molecular_function	ornithine carbamoyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006520	biological_process	amino acid metabolic process
E	0006526	biological_process	L-arginine biosynthetic process
E	0006591	biological_process	ornithine metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0019240	biological_process	citrulline biosynthetic process
E	0042450	biological_process	L-arginine biosynthetic process via ornithine
F	0004585	molecular_function	ornithine carbamoyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006520	biological_process	amino acid metabolic process
F	0006526	biological_process	L-arginine biosynthetic process
F	0006591	biological_process	ornithine metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0019240	biological_process	citrulline biosynthetic process
F	0042450	biological_process	L-arginine biosynthetic process via ornithine

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue PO4 A 401

Chain	Residue
A	ASN248
A	SER249
A	THR274
A	HOH541
A	HOH560

---

site_id	AC2
Number of Residues	5
Details	binding site for residue PO4 B 401

Chain	Residue
C	ASP81
B	SER50
B	THR51
B	ARG52
B	PRO266

---

site_id	AC3
Number of Residues	6
Details	binding site for residue PO4 C 401

Chain	Residue
C	SER249
C	THR274
C	ALA276
C	HOH523
C	HOH526
D	LYS240

---

site_id	AC4
Number of Residues	9
Details	binding site for residue PO4 C 402

Chain	Residue
A	HIS67
B	HIS67
B	HOH618
C	HIS67
C	HOH501
C	HOH502
C	HOH508
C	HOH605
C	HOH619

---

site_id	AC5
Number of Residues	4
Details	binding site for residue PO4 D 401

Chain	Residue
D	SER249
D	THR274
D	HOH526
D	HOH569

---

site_id	AC6
Number of Residues	9
Details	binding site for residue PO4 D 402

Chain	Residue
D	SER50
D	ARG52
D	THR53
D	LEU123
D	HIS128
D	LEU265
D	ARG292
D	HOH503
D	HOH532

---

site_id	AC7
Number of Residues	8
Details	binding site for residue PO4 D 403

Chain	Residue
D	HIS67
D	HOH505
D	HOH524
D	HOH632
E	HIS67
E	HOH662
F	HIS67
F	HOH627

---

site_id	AC8
Number of Residues	8
Details	binding site for residue PO4 E 401

Chain	Residue
E	SER50
E	ARG52
E	THR53
E	HIS128
E	LEU265
E	ARG292
E	HOH529
E	HOH536

---

site_id	AC9
Number of Residues	7
Details	binding site for residue PO4 E 402

Chain	Residue
E	ASN248
E	SER249
E	THR274
E	HOH517
E	HOH546
E	HOH645
E	HOH651

---

site_id	AD1
Number of Residues	6
Details	binding site for residue PO4 F 401

Chain	Residue
A	GLY235
F	ASN248
F	SER249
F	ARG250
F	THR274
F	HOH603

---

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FdKnSTRT

Chain	Residue	Details
A	PHE46-THR53

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	74
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18062991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2I6U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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