7NKX

RNA polymerase II-Spt4/5-nucleosome-Chd1 structure

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000786	cellular_component	nucleosome
a	0003677	molecular_function	DNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005694	cellular_component	chromosome
a	0030527	molecular_function	structural constituent of chromatin
a	0046982	molecular_function	protein heterodimerization activity
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0001172	biological_process	RNA-templated transcription
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005665	cellular_component	RNA polymerase II, core complex
A	0005739	cellular_component	mitochondrion
A	0006351	biological_process	DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0008270	molecular_function	zinc ion binding
A	0010494	cellular_component	cytoplasmic stress granule
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0019985	biological_process	translesion synthesis
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0042789	biological_process	mRNA transcription by RNA polymerase II
A	0046872	molecular_function	metal ion binding
b	0000786	cellular_component	nucleosome
b	0003677	molecular_function	DNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005694	cellular_component	chromosome
b	0006334	biological_process	nucleosome assembly
b	0030527	molecular_function	structural constituent of chromatin
b	0046982	molecular_function	protein heterodimerization activity
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0001172	biological_process	RNA-templated transcription
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003729	molecular_function	mRNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005665	cellular_component	RNA polymerase II, core complex
B	0005739	cellular_component	mitochondrion
B	0006351	biological_process	DNA-templated transcription
B	0006366	biological_process	transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0008270	molecular_function	zinc ion binding
B	0010494	cellular_component	cytoplasmic stress granule
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
c	0000786	cellular_component	nucleosome
c	0003677	molecular_function	DNA binding
c	0005634	cellular_component	nucleus
c	0005694	cellular_component	chromosome
c	0030527	molecular_function	structural constituent of chromatin
c	0031507	biological_process	heterochromatin formation
c	0046982	molecular_function	protein heterodimerization activity
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0001172	biological_process	RNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0003968	molecular_function	RNA-directed RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005665	cellular_component	RNA polymerase II, core complex
C	0006351	biological_process	DNA-templated transcription
C	0006366	biological_process	transcription by RNA polymerase II
C	0006367	biological_process	transcription initiation at RNA polymerase II promoter
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0006369	biological_process	termination of RNA polymerase II transcription
C	0008270	molecular_function	zinc ion binding
C	0046872	molecular_function	metal ion binding
C	0046983	molecular_function	protein dimerization activity
C	0055029	cellular_component	nuclear DNA-directed RNA polymerase complex
d	0000786	cellular_component	nucleosome
d	0003677	molecular_function	DNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005694	cellular_component	chromosome
d	0030527	molecular_function	structural constituent of chromatin
d	0046982	molecular_function	protein heterodimerization activity
D	0000166	molecular_function	nucleotide binding
D	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0000932	cellular_component	P-body
D	0001172	biological_process	RNA-templated transcription
D	0003697	molecular_function	single-stranded DNA binding
D	0003727	molecular_function	single-stranded RNA binding
D	0003968	molecular_function	RNA-directed RNA polymerase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005665	cellular_component	RNA polymerase II, core complex
D	0005737	cellular_component	cytoplasm
D	0006352	biological_process	DNA-templated transcription initiation
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0006397	biological_process	mRNA processing
D	0030880	cellular_component	RNA polymerase complex
D	0031369	molecular_function	translation initiation factor binding
D	0045948	biological_process	positive regulation of translational initiation
D	1990328	cellular_component	RPB4-RPB7 complex
e	0000786	cellular_component	nucleosome
e	0003677	molecular_function	DNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005694	cellular_component	chromosome
e	0030527	molecular_function	structural constituent of chromatin
e	0046982	molecular_function	protein heterodimerization activity
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0001172	biological_process	RNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0003968	molecular_function	RNA-directed RNA polymerase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005736	cellular_component	RNA polymerase I complex
E	0006351	biological_process	DNA-templated transcription
E	0006360	biological_process	transcription by RNA polymerase I
E	0006361	biological_process	transcription initiation at RNA polymerase I promoter
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006363	biological_process	termination of RNA polymerase I transcription
E	0006366	biological_process	transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0006383	biological_process	transcription by RNA polymerase III
E	0006384	biological_process	transcription initiation at RNA polymerase III promoter
E	0006386	biological_process	termination of RNA polymerase III transcription
E	0042254	biological_process	ribosome biogenesis
E	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
E	0042797	biological_process	tRNA transcription by RNA polymerase III
f	0000786	cellular_component	nucleosome
f	0003677	molecular_function	DNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005694	cellular_component	chromosome
f	0006334	biological_process	nucleosome assembly
f	0030527	molecular_function	structural constituent of chromatin
f	0046982	molecular_function	protein heterodimerization activity
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001172	biological_process	RNA-templated transcription
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0003968	molecular_function	RNA-directed RNA polymerase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005736	cellular_component	RNA polymerase I complex
F	0005737	cellular_component	cytoplasm
F	0006351	biological_process	DNA-templated transcription
F	0006360	biological_process	transcription by RNA polymerase I
F	0006361	biological_process	transcription initiation at RNA polymerase I promoter
F	0006362	biological_process	transcription elongation by RNA polymerase I
F	0006363	biological_process	termination of RNA polymerase I transcription
F	0006366	biological_process	transcription by RNA polymerase II
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0006383	biological_process	transcription by RNA polymerase III
F	0006384	biological_process	transcription initiation at RNA polymerase III promoter
F	0006386	biological_process	termination of RNA polymerase III transcription
F	0042254	biological_process	ribosome biogenesis
F	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
F	0042797	biological_process	tRNA transcription by RNA polymerase III
g	0000786	cellular_component	nucleosome
g	0003677	molecular_function	DNA binding
g	0005634	cellular_component	nucleus
g	0005694	cellular_component	chromosome
g	0030527	molecular_function	structural constituent of chromatin
g	0031507	biological_process	heterochromatin formation
g	0046982	molecular_function	protein heterodimerization activity
G	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0000932	cellular_component	P-body
G	0000956	biological_process	nuclear-transcribed mRNA catabolic process
G	0001172	biological_process	RNA-templated transcription
G	0003676	molecular_function	nucleic acid binding
G	0003697	molecular_function	single-stranded DNA binding
G	0003727	molecular_function	single-stranded RNA binding
G	0003968	molecular_function	RNA-directed RNA polymerase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005665	cellular_component	RNA polymerase II, core complex
G	0005737	cellular_component	cytoplasm
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
G	0006366	biological_process	transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0031369	molecular_function	translation initiation factor binding
G	0045948	biological_process	positive regulation of translational initiation
G	0060213	biological_process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
G	1990328	cellular_component	RPB4-RPB7 complex
h	0000786	cellular_component	nucleosome
h	0003677	molecular_function	DNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005694	cellular_component	chromosome
h	0030527	molecular_function	structural constituent of chromatin
h	0046982	molecular_function	protein heterodimerization activity
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0001172	biological_process	RNA-templated transcription
H	0003677	molecular_function	DNA binding
H	0003899	molecular_function	DNA-directed RNA polymerase activity
H	0003968	molecular_function	RNA-directed RNA polymerase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005736	cellular_component	RNA polymerase I complex
H	0006351	biological_process	DNA-templated transcription
H	0006360	biological_process	transcription by RNA polymerase I
H	0006361	biological_process	transcription initiation at RNA polymerase I promoter
H	0006362	biological_process	transcription elongation by RNA polymerase I
H	0006363	biological_process	termination of RNA polymerase I transcription
H	0006366	biological_process	transcription by RNA polymerase II
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0006383	biological_process	transcription by RNA polymerase III
H	0006384	biological_process	transcription initiation at RNA polymerase III promoter
H	0006386	biological_process	termination of RNA polymerase III transcription
H	0042254	biological_process	ribosome biogenesis
H	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
H	0042797	biological_process	tRNA transcription by RNA polymerase III
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001172	biological_process	RNA-templated transcription
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed RNA polymerase activity
I	0003968	molecular_function	RNA-directed RNA polymerase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006281	biological_process	DNA repair
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0006368	biological_process	transcription elongation by RNA polymerase II
I	0006974	biological_process	DNA damage response
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0001172	biological_process	RNA-templated transcription
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed RNA polymerase activity
J	0003968	molecular_function	RNA-directed RNA polymerase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005665	cellular_component	RNA polymerase II, core complex
J	0005666	cellular_component	RNA polymerase III complex
J	0005730	cellular_component	nucleolus
J	0005736	cellular_component	RNA polymerase I complex
J	0006351	biological_process	DNA-templated transcription
J	0006360	biological_process	transcription by RNA polymerase I
J	0006361	biological_process	transcription initiation at RNA polymerase I promoter
J	0006362	biological_process	transcription elongation by RNA polymerase I
J	0006363	biological_process	termination of RNA polymerase I transcription
J	0006366	biological_process	transcription by RNA polymerase II
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0006383	biological_process	transcription by RNA polymerase III
J	0006384	biological_process	transcription initiation at RNA polymerase III promoter
J	0006386	biological_process	termination of RNA polymerase III transcription
J	0008270	molecular_function	zinc ion binding
J	0042254	biological_process	ribosome biogenesis
J	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
J	0042797	biological_process	tRNA transcription by RNA polymerase III
J	0046872	molecular_function	metal ion binding
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0001172	biological_process	RNA-templated transcription
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0003968	molecular_function	RNA-directed RNA polymerase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0006367	biological_process	transcription initiation at RNA polymerase II promoter
K	0006368	biological_process	transcription elongation by RNA polymerase II
K	0006369	biological_process	termination of RNA polymerase II transcription
K	0046983	molecular_function	protein dimerization activity
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0001172	biological_process	RNA-templated transcription
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0003968	molecular_function	RNA-directed RNA polymerase activity
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005730	cellular_component	nucleolus
L	0005736	cellular_component	RNA polymerase I complex
L	0005737	cellular_component	cytoplasm
L	0005777	cellular_component	peroxisome
L	0006351	biological_process	DNA-templated transcription
L	0006360	biological_process	transcription by RNA polymerase I
L	0006361	biological_process	transcription initiation at RNA polymerase I promoter
L	0006362	biological_process	transcription elongation by RNA polymerase I
L	0006363	biological_process	termination of RNA polymerase I transcription
L	0006366	biological_process	transcription by RNA polymerase II
L	0006367	biological_process	transcription initiation at RNA polymerase II promoter
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0006383	biological_process	transcription by RNA polymerase III
L	0006384	biological_process	transcription initiation at RNA polymerase III promoter
L	0006386	biological_process	termination of RNA polymerase III transcription
L	0008270	molecular_function	zinc ion binding
L	0042254	biological_process	ribosome biogenesis
L	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
L	0042797	biological_process	tRNA transcription by RNA polymerase III
L	0046872	molecular_function	metal ion binding
W	0000123	cellular_component	histone acetyltransferase complex
W	0000124	cellular_component	SAGA complex
W	0000166	molecular_function	nucleotide binding
W	0000182	molecular_function	rDNA binding
W	0000724	biological_process	double-strand break repair via homologous recombination
W	0000729	biological_process	DNA double-strand break processing
W	0000785	cellular_component	chromatin
W	0000976	molecular_function	transcription cis-regulatory region binding
W	0001178	biological_process	regulation of transcriptional start site selection at RNA polymerase II promoter
W	0003677	molecular_function	DNA binding
W	0003682	molecular_function	chromatin binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005739	cellular_component	mitochondrion
W	0006325	biological_process	chromatin organization
W	0006338	biological_process	chromatin remodeling
W	0006357	biological_process	regulation of transcription by RNA polymerase II
W	0006363	biological_process	termination of RNA polymerase I transcription
W	0006366	biological_process	transcription by RNA polymerase II
W	0006368	biological_process	transcription elongation by RNA polymerase II
W	0006369	biological_process	termination of RNA polymerase II transcription
W	0007062	biological_process	sister chromatid cohesion
W	0008094	molecular_function	ATP-dependent activity, acting on DNA
W	0010468	biological_process	regulation of gene expression
W	0016787	molecular_function	hydrolase activity
W	0016887	molecular_function	ATP hydrolysis activity
W	0030874	cellular_component	nucleolar chromatin
W	0031490	molecular_function	chromatin DNA binding
W	0034728	biological_process	nucleosome organization
W	0035861	cellular_component	site of double-strand break
W	0042393	molecular_function	histone binding
W	0046695	cellular_component	SLIK (SAGA-like) complex
W	0140002	molecular_function	histone H3K4me3 reader activity
W	0140658	molecular_function	ATP-dependent chromatin remodeler activity
W	1902275	biological_process	regulation of chromatin organization
W	2000104	biological_process	negative regulation of DNA-templated DNA replication
Y	0000182	molecular_function	rDNA binding
Y	0000775	cellular_component	chromosome, centromeric region
Y	0000776	cellular_component	kinetochore
Y	0000785	cellular_component	chromatin
Y	0000993	molecular_function	RNA polymerase II complex binding
Y	0003727	molecular_function	single-stranded RNA binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005694	cellular_component	chromosome
Y	0006325	biological_process	chromatin organization
Y	0006355	biological_process	regulation of DNA-templated transcription
Y	0006368	biological_process	transcription elongation by RNA polymerase II
Y	0006370	biological_process	7-methylguanosine mRNA capping
Y	0006397	biological_process	mRNA processing
Y	0008270	molecular_function	zinc ion binding
Y	0008298	biological_process	intracellular mRNA localization
Y	0010467	biological_process	gene expression
Y	0010507	biological_process	negative regulation of autophagy
Y	0031507	biological_process	heterochromatin formation
Y	0031934	cellular_component	mating-type region heterochromatin
Y	0032044	cellular_component	DSIF complex
Y	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Y	0033553	cellular_component	rDNA heterochromatin
Y	0044877	molecular_function	protein-containing complex binding
Y	0046872	molecular_function	metal ion binding
Y	0090262	biological_process	regulation of transcription-coupled nucleotide-excision repair
Y	0140673	biological_process	transcription elongation-coupled chromatin remodeling
Y	2000232	biological_process	regulation of rRNA processing
Y	2001208	biological_process	negative regulation of transcription elongation by RNA polymerase I
Y	2001209	biological_process	positive regulation of transcription elongation by RNA polymerase I
Z	0000245	biological_process	spliceosomal complex assembly
Z	0000785	cellular_component	chromatin
Z	0000993	molecular_function	RNA polymerase II complex binding
Z	0001042	molecular_function	RNA polymerase I core binding
Z	0001179	molecular_function	RNA polymerase I general transcription initiation factor binding
Z	0003677	molecular_function	DNA binding
Z	0003727	molecular_function	single-stranded RNA binding
Z	0003729	molecular_function	mRNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005694	cellular_component	chromosome
Z	0005739	cellular_component	mitochondrion
Z	0006338	biological_process	chromatin remodeling
Z	0006354	biological_process	DNA-templated transcription elongation
Z	0006355	biological_process	regulation of DNA-templated transcription
Z	0006357	biological_process	regulation of transcription by RNA polymerase II
Z	0006368	biological_process	transcription elongation by RNA polymerase II
Z	0006397	biological_process	mRNA processing
Z	0008298	biological_process	intracellular mRNA localization
Z	0010508	biological_process	positive regulation of autophagy
Z	0017070	molecular_function	U6 snRNA binding
Z	0019843	molecular_function	rRNA binding
Z	0030619	molecular_function	U1 snRNA binding
Z	0030620	molecular_function	U2 snRNA binding
Z	0030621	molecular_function	U4 snRNA binding
Z	0030623	molecular_function	U5 snRNA binding
Z	0032044	cellular_component	DSIF complex
Z	0032784	biological_process	regulation of DNA-templated transcription elongation
Z	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Z	0032991	cellular_component	protein-containing complex
Z	0033553	cellular_component	rDNA heterochromatin
Z	0042393	molecular_function	histone binding
Z	0044877	molecular_function	protein-containing complex binding
Z	0070990	molecular_function	snRNP binding
Z	0090262	biological_process	regulation of transcription-coupled nucleotide-excision repair
Z	2000232	biological_process	regulation of rRNA processing
Z	2001208	biological_process	negative regulation of transcription elongation by RNA polymerase I
Z	2001209	biological_process	positive regulation of transcription elongation by RNA polymerase I

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
c	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
b	GLY14-HIS18

---

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
A	TYR1549-ALA1555
A	TYR1612-SER1618
A	TYR1619-SER1625
A	TYR1626-SER1632
A	TYR1633-SER1639
A	TYR1640-SER1646
A	TYR1647-SER1653
A	TYR1654-ALA1660
A	TYR1661-SER1667
A	TYR1668-SER1674
A	TYR1675-SER1681
A	TYR1556-SER1562
A	TYR1682-SER1688
A	TYR1689-ASN1695
A	TYR1696-SER1702
A	TYR1563-SER1569
A	TYR1570-SER1576
A	TYR1577-SER1583
A	TYR1584-SER1590
A	TYR1591-SER1597
A	TYR1598-SER1604
A	TYR1605-SER1611

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
a	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
d	ARG89-GLY111

---

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSLRRvmiaeiptlAidsVevetNtTvlaDEfIAhRLGLIP

Chain	Residue	Details
C	ASN31-PRO71

---

site_id	PS00466
Number of Residues	36
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CpkChsrenvffqSQQRRkDTSmvlffvCls...CshiF

Chain	Residue	Details
I	CYS75-PHE110

---

site_id	PS00598
Number of Residues	21
Details	CHROMO_1 Chromo domain signature. FlIKWtDEshlhn.TWETyesI

Chain	Residue	Details
W	PHE213-ILE233
W	TYR307-ILE327

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
a	PRO66-ILE74

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCRDCNNMLypredkennrllfeCrtC

Chain	Residue	Details
I	PHE6-CYS32

---

site_id	PS01108
Number of Residues	18
Details	RIBOSOMAL_L24 Ribosomal protein L24 signature. GDrIeVLnGeqRGsk.GiV

Chain	Residue	Details
Z	GLY537-VAL554

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPKHirLssDE

Chain	Residue	Details
E	HIS147-GLU160

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARiLGtRAlQ

Chain	Residue	Details
F	THR86-GLN100

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IVPVrCFSCG

Chain	Residue	Details
J	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. FekEdHTLgNlIraeLlndrkVlfaaYkveHP

Chain	Residue	Details
K	PHE35-PRO66

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY977-THR989

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	ZN_FING: C4-type => ECO:0000255

Chain	Residue	Details
Y	CYS7-CYS27
A	ASP483
A	ASP485
J	CYS10
J	CYS45
J	CYS46
h	LYS2
h	LYS9
h	LYS12
h	LYS17
A	ASP481

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
J	LYS59
D	THR92
B	CYS1166
B	CYS1182
B	CYS1185

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10145, ECO:0000269|PubMed:11313498, ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:15537538, ECO:0000305|PubMed:11313499

Chain	Residue	Details
I	CYS7
I	CYS10
I	CYS29
I	CYS32

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00472, ECO:0000269|PubMed:11313498, ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:15537538, ECO:0000305|PubMed:11313499

Chain	Residue	Details
I	CYS75
I	CYS78
I	CYS103
I	CYS106

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
I	SER40
c	LYS75
g	LYS74
g	LYS75
f	LYS8
f	LYS16
f	LYS44
f	LYS79

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
W	SER1372
g	GLN104
f	LYS12
f	LYS20

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:12872131

Chain	Residue	Details
W	LYS1144
g	LYS118
f	LYS31
f	LYS91

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250

Chain	Residue	Details
c	LYS13
f	SER47
c	LYS15
c	LYS119
g	LYS13
g	LYS15
g	LYS119

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
b	TYR51
b	TYR88
f	TYR51
f	TYR88

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
b	LYS59
e	LYS64
f	LYS59
a	LYS27
a	LYS36
a	LYS64
e	LYS18
e	LYS23
e	LYS27
e	LYS36

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
b	LYS77
f	LYS77

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
b	LYS31
f	LYS31

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
a	LYS37
b	LYS91
f	LYS91

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
a	TYR41
e	TYR41

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84228

Chain	Residue	Details
a	LYS56
a	LYS79
e	LYS56
e	LYS79

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
a	SER57
e	SER57

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
a	THR80
a	THR107
e	THR80
e	THR107

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
a	SER86
e	SER86

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
a	LYS115
e	LYS115

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
a	LYS122
e	LYS122

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
a	CYS110
e	CYS110

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 788

Chain	Residue	Details
B	ASP837	metal ligand
A	ASP483	metal ligand
A	ASP485	metal ligand

---