7NJ4
1918 H1N1 Viral influenza polymerase heterotrimer with Nb8198 core
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0039523 | biological_process | symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity |
| A | 0039657 | biological_process | symbiont-mediated suppression of host gene expression |
| A | 0039694 | biological_process | viral RNA genome replication |
| A | 0042025 | cellular_component | host cell nucleus |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0075523 | biological_process | viral translational frameshifting |
| A | 0075526 | biological_process | cap snatching |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0001172 | biological_process | RNA-templated transcription |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0019083 | biological_process | viral transcription |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| B | 0039523 | biological_process | symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity |
| B | 0039657 | biological_process | symbiont-mediated suppression of host gene expression |
| B | 0039694 | biological_process | viral RNA genome replication |
| B | 0042025 | cellular_component | host cell nucleus |
| C | 0003723 | molecular_function | RNA binding |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0019865 | molecular_function | immunoglobulin binding |
| C | 0039694 | biological_process | viral RNA genome replication |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 15 |
| Details | Motif: {"description":"Nuclear localization signal 1 (NLS1)","evidences":[{"source":"UniProtKB","id":"P03433","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 63 |
| Details | Motif: {"description":"Nuclear localization signal 2 (NLS2)","evidences":[{"source":"UniProtKB","id":"P03433","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 197 |
| Details | Domain: {"description":"RdRp catalytic","evidences":[{"source":"HAMAP-Rule","id":"MF_04065","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 29 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 7 |
| Details | Region: {"description":"Promoter-binding site","evidences":[{"source":"HAMAP-Rule","id":"MF_04065","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 9 |
| Details | Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
