Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7NIE

putative glycerol kinase-like proteins anchored on an array of voltage dependent anion channels in the outer mitochondrial membrane of pig sperm mitochondria

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004370	molecular_function	glycerol kinase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005975	biological_process	carbohydrate metabolic process
A	0006071	biological_process	glycerol metabolic process
A	0006641	biological_process	triglyceride metabolic process
A	0016301	molecular_function	kinase activity
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0019563	biological_process	glycerol catabolic process
A	0046167	biological_process	glycerol-3-phosphate biosynthetic process
B	0004370	molecular_function	glycerol kinase activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005975	biological_process	carbohydrate metabolic process
B	0006071	biological_process	glycerol metabolic process
B	0006641	biological_process	triglyceride metabolic process
B	0016301	molecular_function	kinase activity
B	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
B	0019563	biological_process	glycerol catabolic process
B	0046167	biological_process	glycerol-3-phosphate biosynthetic process
C	0005244	molecular_function	voltage-gated monoatomic ion channel activity
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0006820	biological_process	monoatomic anion transport
C	0008142	molecular_function	oxysterol binding
C	0008308	molecular_function	voltage-gated monoatomic anion channel activity
C	0015485	molecular_function	cholesterol binding
C	0016020	cellular_component	membrane
C	0031210	molecular_function	phosphatidylcholine binding
C	0055085	biological_process	transmembrane transport
C	0097001	molecular_function	ceramide binding
C	0097225	cellular_component	sperm midpiece
C	0097345	biological_process	mitochondrial outer membrane permeabilization
C	0098656	biological_process	monoatomic anion transmembrane transport
D	0005244	molecular_function	voltage-gated monoatomic ion channel activity
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0006820	biological_process	monoatomic anion transport
D	0008142	molecular_function	oxysterol binding
D	0008308	molecular_function	voltage-gated monoatomic anion channel activity
D	0015485	molecular_function	cholesterol binding
D	0016020	cellular_component	membrane
D	0031210	molecular_function	phosphatidylcholine binding
D	0055085	biological_process	transmembrane transport
D	0097001	molecular_function	ceramide binding
D	0097225	cellular_component	sperm midpiece
D	0097345	biological_process	mitochondrial outer membrane permeabilization
D	0098656	biological_process	monoatomic anion transmembrane transport
E	0005244	molecular_function	voltage-gated monoatomic ion channel activity
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0006820	biological_process	monoatomic anion transport
E	0008142	molecular_function	oxysterol binding
E	0008308	molecular_function	voltage-gated monoatomic anion channel activity
E	0015485	molecular_function	cholesterol binding
E	0016020	cellular_component	membrane
E	0031210	molecular_function	phosphatidylcholine binding
E	0055085	biological_process	transmembrane transport
E	0097001	molecular_function	ceramide binding
E	0097225	cellular_component	sperm midpiece
E	0097345	biological_process	mitochondrial outer membrane permeabilization
E	0098656	biological_process	monoatomic anion transmembrane transport
F	0005244	molecular_function	voltage-gated monoatomic ion channel activity
F	0005739	cellular_component	mitochondrion
F	0005741	cellular_component	mitochondrial outer membrane
F	0006820	biological_process	monoatomic anion transport
F	0008142	molecular_function	oxysterol binding
F	0008308	molecular_function	voltage-gated monoatomic anion channel activity
F	0015485	molecular_function	cholesterol binding
F	0016020	cellular_component	membrane
F	0031210	molecular_function	phosphatidylcholine binding
F	0055085	biological_process	transmembrane transport
F	0097001	molecular_function	ceramide binding
F	0097225	cellular_component	sperm midpiece
F	0097345	biological_process	mitochondrial outer membrane permeabilization
F	0098656	biological_process	monoatomic anion transmembrane transport
G	0005244	molecular_function	voltage-gated monoatomic ion channel activity
G	0005739	cellular_component	mitochondrion
G	0005741	cellular_component	mitochondrial outer membrane
G	0006820	biological_process	monoatomic anion transport
G	0008142	molecular_function	oxysterol binding
G	0008308	molecular_function	voltage-gated monoatomic anion channel activity
G	0015485	molecular_function	cholesterol binding
G	0016020	cellular_component	membrane
G	0031210	molecular_function	phosphatidylcholine binding
G	0055085	biological_process	transmembrane transport
G	0097001	molecular_function	ceramide binding
G	0097225	cellular_component	sperm midpiece
G	0097345	biological_process	mitochondrial outer membrane permeabilization
G	0098656	biological_process	monoatomic anion transmembrane transport
H	0005244	molecular_function	voltage-gated monoatomic ion channel activity
H	0005739	cellular_component	mitochondrion
H	0005741	cellular_component	mitochondrial outer membrane
H	0006820	biological_process	monoatomic anion transport
H	0008142	molecular_function	oxysterol binding
H	0008308	molecular_function	voltage-gated monoatomic anion channel activity
H	0015485	molecular_function	cholesterol binding
H	0016020	cellular_component	membrane
H	0031210	molecular_function	phosphatidylcholine binding
H	0055085	biological_process	transmembrane transport
H	0097001	molecular_function	ceramide binding
H	0097225	cellular_component	sperm midpiece
H	0097345	biological_process	mitochondrial outer membrane permeabilization
H	0098656	biological_process	monoatomic anion transmembrane transport
I	0005244	molecular_function	voltage-gated monoatomic ion channel activity
I	0005739	cellular_component	mitochondrion
I	0005741	cellular_component	mitochondrial outer membrane
I	0006820	biological_process	monoatomic anion transport
I	0008142	molecular_function	oxysterol binding
I	0008308	molecular_function	voltage-gated monoatomic anion channel activity
I	0015485	molecular_function	cholesterol binding
I	0016020	cellular_component	membrane
I	0031210	molecular_function	phosphatidylcholine binding
I	0055085	biological_process	transmembrane transport
I	0097001	molecular_function	ceramide binding
I	0097225	cellular_component	sperm midpiece
I	0097345	biological_process	mitochondrial outer membrane permeabilization
I	0098656	biological_process	monoatomic anion transmembrane transport
J	0005244	molecular_function	voltage-gated monoatomic ion channel activity
J	0005739	cellular_component	mitochondrion
J	0005741	cellular_component	mitochondrial outer membrane
J	0006820	biological_process	monoatomic anion transport
J	0008142	molecular_function	oxysterol binding
J	0008308	molecular_function	voltage-gated monoatomic anion channel activity
J	0015485	molecular_function	cholesterol binding
J	0016020	cellular_component	membrane
J	0031210	molecular_function	phosphatidylcholine binding
J	0055085	biological_process	transmembrane transport
J	0097001	molecular_function	ceramide binding
J	0097225	cellular_component	sperm midpiece
J	0097345	biological_process	mitochondrial outer membrane permeabilization
J	0098656	biological_process	monoatomic anion transmembrane transport
K	0005244	molecular_function	voltage-gated monoatomic ion channel activity
K	0005739	cellular_component	mitochondrion
K	0005741	cellular_component	mitochondrial outer membrane
K	0006820	biological_process	monoatomic anion transport
K	0008142	molecular_function	oxysterol binding
K	0008308	molecular_function	voltage-gated monoatomic anion channel activity
K	0015485	molecular_function	cholesterol binding
K	0016020	cellular_component	membrane
K	0031210	molecular_function	phosphatidylcholine binding
K	0055085	biological_process	transmembrane transport
K	0097001	molecular_function	ceramide binding
K	0097225	cellular_component	sperm midpiece
K	0097345	biological_process	mitochondrial outer membrane permeabilization
K	0098656	biological_process	monoatomic anion transmembrane transport
L	0005244	molecular_function	voltage-gated monoatomic ion channel activity
L	0005739	cellular_component	mitochondrion
L	0005741	cellular_component	mitochondrial outer membrane
L	0006820	biological_process	monoatomic anion transport
L	0008142	molecular_function	oxysterol binding
L	0008308	molecular_function	voltage-gated monoatomic anion channel activity
L	0015485	molecular_function	cholesterol binding
L	0016020	cellular_component	membrane
L	0031210	molecular_function	phosphatidylcholine binding
L	0055085	biological_process	transmembrane transport
L	0097001	molecular_function	ceramide binding
L	0097225	cellular_component	sperm midpiece
L	0097345	biological_process	mitochondrial outer membrane permeabilization
L	0098656	biological_process	monoatomic anion transmembrane transport
M	0005244	molecular_function	voltage-gated monoatomic ion channel activity
M	0005739	cellular_component	mitochondrion
M	0005741	cellular_component	mitochondrial outer membrane
M	0006820	biological_process	monoatomic anion transport
M	0008142	molecular_function	oxysterol binding
M	0008308	molecular_function	voltage-gated monoatomic anion channel activity
M	0015485	molecular_function	cholesterol binding
M	0016020	cellular_component	membrane
M	0031210	molecular_function	phosphatidylcholine binding
M	0055085	biological_process	transmembrane transport
M	0097001	molecular_function	ceramide binding
M	0097225	cellular_component	sperm midpiece
M	0097345	biological_process	mitochondrial outer membrane permeabilization
M	0098656	biological_process	monoatomic anion transmembrane transport
N	0005244	molecular_function	voltage-gated monoatomic ion channel activity
N	0005739	cellular_component	mitochondrion
N	0005741	cellular_component	mitochondrial outer membrane
N	0006820	biological_process	monoatomic anion transport
N	0008142	molecular_function	oxysterol binding
N	0008308	molecular_function	voltage-gated monoatomic anion channel activity
N	0015485	molecular_function	cholesterol binding
N	0016020	cellular_component	membrane
N	0031210	molecular_function	phosphatidylcholine binding
N	0055085	biological_process	transmembrane transport
N	0097001	molecular_function	ceramide binding
N	0097225	cellular_component	sperm midpiece
N	0097345	biological_process	mitochondrial outer membrane permeabilization
N	0098656	biological_process	monoatomic anion transmembrane transport
O	0004370	molecular_function	glycerol kinase activity
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005741	cellular_component	mitochondrial outer membrane
O	0005975	biological_process	carbohydrate metabolic process
O	0006071	biological_process	glycerol metabolic process
O	0006641	biological_process	triglyceride metabolic process
O	0016301	molecular_function	kinase activity
O	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
O	0019563	biological_process	glycerol catabolic process
O	0046167	biological_process	glycerol-3-phosphate biosynthetic process
P	0004370	molecular_function	glycerol kinase activity
P	0005737	cellular_component	cytoplasm
P	0005739	cellular_component	mitochondrion
P	0005741	cellular_component	mitochondrial outer membrane
P	0005975	biological_process	carbohydrate metabolic process
P	0006071	biological_process	glycerol metabolic process
P	0006641	biological_process	triglyceride metabolic process
P	0016301	molecular_function	kinase activity
P	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
P	0019563	biological_process	glycerol catabolic process
P	0046167	biological_process	glycerol-3-phosphate biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00445
Number of Residues	21
Details	FGGY_KINASES_2 FGGY family of carbohydrate kinases signature 2. GiICGLtqftnkc.HIAFAALE

Chain	Residue	Details
A	GLY351-GLU371

site_id	PS00558
Number of Residues	23
Details	EUKARYOTIC_PORIN Eukaryotic mitochondrial porin signature. YqlDPtAsisAKVNNssliGVgY

Chain	Residue	Details
C	TYR236-TYR258

site_id	PS00933
Number of Residues	13
Details	FGGY_KINASES_1 FGGY family of carbohydrate kinases signature 1. YfSavKLRWLLDN

Chain	Residue	Details
A	TYR148-ASN160

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	564
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P45880","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	276
Details	Intramembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"P45880","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1968
Details	Transmembrane: {"description":"Beta stranded","evidences":[{"source":"UniProtKB","id":"P45880","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	240
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"UniProtKB","id":"P45880","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	48
Details	Motif: {"description":"Mitochondrial localization signal","evidences":[{"source":"UniProtKB","id":"J5JPV3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	120
Details	Motif: {"description":"C-terminal beta-signal","evidences":[{"source":"UniProtKB","id":"J5JPV3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q60932","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P21796","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Site: {"description":"Involved in ceramide and phosphatidylcholine binding","evidences":[{"source":"UniProtKB","id":"P45880","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	12
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P45880","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	12
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q60930","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	12
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q60932","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	12
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P21796","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q60930","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P21796","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P21796","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	48
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P45880","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P45880","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P21796","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)