7NGW

Mycobacterium tuberculosis transcriptional regulator EthR with bound inhibitory compound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue UAW A 301

Chain	Residue
A	ILE107
A	LEU183
A	TRP207
A	PHE110
A	TRP138
A	MET142
A	TYR148
A	THR149
A	ASN176
A	ASN179
A	GLU180

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 302

Chain	Residue
A	SER46
A	VAL47
A	ASP48
A	ARG58

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 303

Chain	Residue
A	ARG25
A	PHE63
A	GLU112

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 304

Chain	Residue
A	PHE111
A	GLU112
A	GLY115
A	GLU196

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 A 305

Chain	Residue
A	ASP84
A	LEU87
A	GLN88
A	LYS144

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Domain: {"description":"HTH tetR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	19
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Inhibitor-binding"}

Chain

Residue

Details

---