Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7NEP

Homology model of the in situ actomyosin complex from the A-band of mouse psoas muscle sarcomere in the rigor state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001725	cellular_component	stress fiber
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005865	cellular_component	striated muscle thin filament
A	0005884	cellular_component	actin filament
A	0009612	biological_process	response to mechanical stimulus
A	0009991	biological_process	obsolete response to extracellular stimulus
A	0010628	biological_process	positive regulation of gene expression
A	0015629	cellular_component	actin cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0030017	cellular_component	sarcomere
A	0030027	cellular_component	lamellipodium
A	0030175	cellular_component	filopodium
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0032991	cellular_component	protein-containing complex
A	0043503	biological_process	skeletal muscle fiber adaptation
A	0044297	cellular_component	cell body
A	0048545	biological_process	response to steroid hormone
A	0048741	biological_process	skeletal muscle fiber development
A	0071417	biological_process	cellular response to organonitrogen compound
A	0090131	biological_process	mesenchyme migration
B	0001725	cellular_component	stress fiber
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0009612	biological_process	response to mechanical stimulus
B	0009991	biological_process	obsolete response to extracellular stimulus
B	0010628	biological_process	positive regulation of gene expression
B	0015629	cellular_component	actin cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0030017	cellular_component	sarcomere
B	0030027	cellular_component	lamellipodium
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0032991	cellular_component	protein-containing complex
B	0043503	biological_process	skeletal muscle fiber adaptation
B	0044297	cellular_component	cell body
B	0048545	biological_process	response to steroid hormone
B	0048741	biological_process	skeletal muscle fiber development
B	0071417	biological_process	cellular response to organonitrogen compound
B	0090131	biological_process	mesenchyme migration
C	0001725	cellular_component	stress fiber
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0009612	biological_process	response to mechanical stimulus
C	0009991	biological_process	obsolete response to extracellular stimulus
C	0010628	biological_process	positive regulation of gene expression
C	0015629	cellular_component	actin cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0030017	cellular_component	sarcomere
C	0030027	cellular_component	lamellipodium
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0032991	cellular_component	protein-containing complex
C	0043503	biological_process	skeletal muscle fiber adaptation
C	0044297	cellular_component	cell body
C	0048545	biological_process	response to steroid hormone
C	0048741	biological_process	skeletal muscle fiber development
C	0071417	biological_process	cellular response to organonitrogen compound
C	0090131	biological_process	mesenchyme migration
D	0001725	cellular_component	stress fiber
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005865	cellular_component	striated muscle thin filament
D	0005884	cellular_component	actin filament
D	0009612	biological_process	response to mechanical stimulus
D	0009991	biological_process	obsolete response to extracellular stimulus
D	0010628	biological_process	positive regulation of gene expression
D	0015629	cellular_component	actin cytoskeleton
D	0016787	molecular_function	hydrolase activity
D	0030017	cellular_component	sarcomere
D	0030027	cellular_component	lamellipodium
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0032991	cellular_component	protein-containing complex
D	0043503	biological_process	skeletal muscle fiber adaptation
D	0044297	cellular_component	cell body
D	0048545	biological_process	response to steroid hormone
D	0048741	biological_process	skeletal muscle fiber development
D	0071417	biological_process	cellular response to organonitrogen compound
D	0090131	biological_process	mesenchyme migration
E	0001725	cellular_component	stress fiber
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005865	cellular_component	striated muscle thin filament
E	0005884	cellular_component	actin filament
E	0009612	biological_process	response to mechanical stimulus
E	0009991	biological_process	obsolete response to extracellular stimulus
E	0010628	biological_process	positive regulation of gene expression
E	0015629	cellular_component	actin cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0030017	cellular_component	sarcomere
E	0030027	cellular_component	lamellipodium
E	0030175	cellular_component	filopodium
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0032991	cellular_component	protein-containing complex
E	0043503	biological_process	skeletal muscle fiber adaptation
E	0044297	cellular_component	cell body
E	0048545	biological_process	response to steroid hormone
E	0048741	biological_process	skeletal muscle fiber development
E	0071417	biological_process	cellular response to organonitrogen compound
E	0090131	biological_process	mesenchyme migration
F	0001725	cellular_component	stress fiber
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005865	cellular_component	striated muscle thin filament
F	0005884	cellular_component	actin filament
F	0009612	biological_process	response to mechanical stimulus
F	0009991	biological_process	obsolete response to extracellular stimulus
F	0010628	biological_process	positive regulation of gene expression
F	0015629	cellular_component	actin cytoskeleton
F	0016787	molecular_function	hydrolase activity
F	0030017	cellular_component	sarcomere
F	0030027	cellular_component	lamellipodium
F	0030175	cellular_component	filopodium
F	0030240	biological_process	skeletal muscle thin filament assembly
F	0032991	cellular_component	protein-containing complex
F	0043503	biological_process	skeletal muscle fiber adaptation
F	0044297	cellular_component	cell body
F	0048545	biological_process	response to steroid hormone
F	0048741	biological_process	skeletal muscle fiber development
F	0071417	biological_process	cellular response to organonitrogen compound
F	0090131	biological_process	mesenchyme migration
G	0001725	cellular_component	stress fiber
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005865	cellular_component	striated muscle thin filament
G	0005884	cellular_component	actin filament
G	0009612	biological_process	response to mechanical stimulus
G	0009991	biological_process	obsolete response to extracellular stimulus
G	0010628	biological_process	positive regulation of gene expression
G	0015629	cellular_component	actin cytoskeleton
G	0016787	molecular_function	hydrolase activity
G	0030017	cellular_component	sarcomere
G	0030027	cellular_component	lamellipodium
G	0030175	cellular_component	filopodium
G	0030240	biological_process	skeletal muscle thin filament assembly
G	0032991	cellular_component	protein-containing complex
G	0043503	biological_process	skeletal muscle fiber adaptation
G	0044297	cellular_component	cell body
G	0048545	biological_process	response to steroid hormone
G	0048741	biological_process	skeletal muscle fiber development
G	0071417	biological_process	cellular response to organonitrogen compound
G	0090131	biological_process	mesenchyme migration
H	0001725	cellular_component	stress fiber
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005865	cellular_component	striated muscle thin filament
H	0005884	cellular_component	actin filament
H	0009612	biological_process	response to mechanical stimulus
H	0009991	biological_process	obsolete response to extracellular stimulus
H	0010628	biological_process	positive regulation of gene expression
H	0015629	cellular_component	actin cytoskeleton
H	0016787	molecular_function	hydrolase activity
H	0030017	cellular_component	sarcomere
H	0030027	cellular_component	lamellipodium
H	0030175	cellular_component	filopodium
H	0030240	biological_process	skeletal muscle thin filament assembly
H	0032991	cellular_component	protein-containing complex
H	0043503	biological_process	skeletal muscle fiber adaptation
H	0044297	cellular_component	cell body
H	0048545	biological_process	response to steroid hormone
H	0048741	biological_process	skeletal muscle fiber development
H	0071417	biological_process	cellular response to organonitrogen compound
H	0090131	biological_process	mesenchyme migration
I	0001725	cellular_component	stress fiber
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005865	cellular_component	striated muscle thin filament
I	0005884	cellular_component	actin filament
I	0009612	biological_process	response to mechanical stimulus
I	0009991	biological_process	obsolete response to extracellular stimulus
I	0010628	biological_process	positive regulation of gene expression
I	0015629	cellular_component	actin cytoskeleton
I	0016787	molecular_function	hydrolase activity
I	0030017	cellular_component	sarcomere
I	0030027	cellular_component	lamellipodium
I	0030175	cellular_component	filopodium
I	0030240	biological_process	skeletal muscle thin filament assembly
I	0032991	cellular_component	protein-containing complex
I	0043503	biological_process	skeletal muscle fiber adaptation
I	0044297	cellular_component	cell body
I	0048545	biological_process	response to steroid hormone
I	0048741	biological_process	skeletal muscle fiber development
I	0071417	biological_process	cellular response to organonitrogen compound
I	0090131	biological_process	mesenchyme migration
J	0001725	cellular_component	stress fiber
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005865	cellular_component	striated muscle thin filament
J	0005884	cellular_component	actin filament
J	0009612	biological_process	response to mechanical stimulus
J	0009991	biological_process	obsolete response to extracellular stimulus
J	0010628	biological_process	positive regulation of gene expression
J	0015629	cellular_component	actin cytoskeleton
J	0016787	molecular_function	hydrolase activity
J	0030017	cellular_component	sarcomere
J	0030027	cellular_component	lamellipodium
J	0030175	cellular_component	filopodium
J	0030240	biological_process	skeletal muscle thin filament assembly
J	0032991	cellular_component	protein-containing complex
J	0043503	biological_process	skeletal muscle fiber adaptation
J	0044297	cellular_component	cell body
J	0048545	biological_process	response to steroid hormone
J	0048741	biological_process	skeletal muscle fiber development
J	0071417	biological_process	cellular response to organonitrogen compound
J	0090131	biological_process	mesenchyme migration
K	0001725	cellular_component	stress fiber
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005865	cellular_component	striated muscle thin filament
K	0005884	cellular_component	actin filament
K	0009612	biological_process	response to mechanical stimulus
K	0009991	biological_process	obsolete response to extracellular stimulus
K	0010628	biological_process	positive regulation of gene expression
K	0015629	cellular_component	actin cytoskeleton
K	0016787	molecular_function	hydrolase activity
K	0030017	cellular_component	sarcomere
K	0030027	cellular_component	lamellipodium
K	0030175	cellular_component	filopodium
K	0030240	biological_process	skeletal muscle thin filament assembly
K	0032991	cellular_component	protein-containing complex
K	0043503	biological_process	skeletal muscle fiber adaptation
K	0044297	cellular_component	cell body
K	0048545	biological_process	response to steroid hormone
K	0048741	biological_process	skeletal muscle fiber development
K	0071417	biological_process	cellular response to organonitrogen compound
K	0090131	biological_process	mesenchyme migration
L	0003774	molecular_function	cytoskeletal motor activity
L	0005524	molecular_function	ATP binding
L	0016459	cellular_component	myosin complex
L	0051015	molecular_function	actin filament binding
M	0003774	molecular_function	cytoskeletal motor activity
M	0005524	molecular_function	ATP binding
M	0016459	cellular_component	myosin complex
M	0051015	molecular_function	actin filament binding
N	0005509	molecular_function	calcium ion binding
O	0005509	molecular_function	calcium ion binding
R	0005509	molecular_function	calcium ion binding
S	0005509	molecular_function	calcium ion binding

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DQNRDGIIDkeDL

Chain	Residue	Details
R	ASP38-LEU50

site_id	PS00326
Number of Residues	9
Details	TROPOMYOSIN Tropomyosins signature. LKEAEtRAE

Chain	Residue	Details
P	LEU232-GLU240

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR55-GLY65

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
A	TRP358-GLU366

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU106-ARG118

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00448

Chain	Residue	Details
R	ASP38
E	MET49
F	MET46
F	MET49
G	MET46
G	MET49
H	MET46
H	MET49
I	MET46
I	MET49
J	MET46
R	ASN40
J	MET49
K	MET46
K	MET49
R	ASP42
R	ASP49
S	ASP38
S	ASN40
S	ASP42
S	ASP49
E	MET46

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P04466

Chain	Residue	Details
R	THR25
T	SER186
T	SER206
T	SER252
U	SER174
U	SER186
U	SER206
U	SER252
R	THR35
R	THR101
S	THR25
S	THR35
S	THR101
M	SER392
M	SER625
T	SER174

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P04466

Chain	Residue	Details
R	SER75
M	THR776
K	HIS75
S	SER75
L	THR391
L	THR419
L	THR776
M	THR64
M	THR69
M	THR391
M	THR419

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6,N6,N6-trimethyllysine => ECO:0000255

Chain	Residue	Details
L	LYS130
J	LYS86
K	LYS86
M	LYS130
C	LYS86
D	LYS86
E	LYS86
F	LYS86
G	LYS86
H	LYS86
I	LYS86

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:Q29RW1

Chain	Residue	Details
L	TYR389
L	TYR424
M	TYR389
M	TYR424

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Pros-methylhistidine => ECO:0000250\|UniProtKB:Q28641

Chain	Residue	Details
L	HIS757
M	HIS757

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)