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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7NDU

Gag:02 TCR in complex with HLA-E featuring a non-natural amino acid

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
BBB0000139cellular_componentGolgi membrane
BBB0002376biological_processimmune system process
BBB0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
BBB0002477biological_processantigen processing and presentation of exogenous peptide antigen via MHC class Ib
BBB0002502biological_processpeptide antigen assembly with MHC class I protein complex
BBB0002503biological_processpeptide antigen assembly with MHC class II protein complex
BBB0002715biological_processregulation of natural killer cell mediated immunity
BBB0002726biological_processpositive regulation of T cell cytokine production
BBB0005198molecular_functionstructural molecule activity
BBB0005515molecular_functionprotein binding
BBB0005576cellular_componentextracellular region
BBB0005615cellular_componentextracellular space
BBB0005765cellular_componentlysosomal membrane
BBB0005783cellular_componentendoplasmic reticulum
BBB0005788cellular_componentendoplasmic reticulum lumen
BBB0005794cellular_componentGolgi apparatus
BBB0005886cellular_componentplasma membrane
BBB0005925cellular_componentfocal adhesion
BBB0006879biological_processintracellular iron ion homeostasis
BBB0006955biological_processimmune response
BBB0007608biological_processsensory perception of smell
BBB0007611biological_processlearning or memory
BBB0009897cellular_componentexternal side of plasma membrane
BBB0009986cellular_componentcell surface
BBB0010038biological_processresponse to metal ion
BBB0012507cellular_componentER to Golgi transport vesicle membrane
BBB0016020cellular_componentmembrane
BBB0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
BBB0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
BBB0023026molecular_functionMHC class II protein complex binding
BBB0030670cellular_componentphagocytic vesicle membrane
BBB0031901cellular_componentearly endosome membrane
BBB0031902cellular_componentlate endosome membrane
BBB0031905cellular_componentearly endosome lumen
BBB0033572biological_processtransferrin transport
BBB0034756biological_processregulation of iron ion transport
BBB0034757biological_processnegative regulation of iron ion transport
BBB0035580cellular_componentspecific granule lumen
BBB0042605molecular_functionpeptide antigen binding
BBB0042612cellular_componentMHC class I protein complex
BBB0042613cellular_componentMHC class II protein complex
BBB0042802molecular_functionidentical protein binding
BBB0042803molecular_functionprotein homodimerization activity
BBB0042824cellular_componentMHC class I peptide loading complex
BBB0048260biological_processpositive regulation of receptor-mediated endocytosis
BBB0048261biological_processnegative regulation of receptor-mediated endocytosis
BBB0050680biological_processnegative regulation of epithelial cell proliferation
BBB0050768biological_processnegative regulation of neurogenesis
BBB0050778biological_processpositive regulation of immune response
BBB0050870biological_processpositive regulation of T cell activation
BBB0051289biological_processprotein homotetramerization
BBB0055038cellular_componentrecycling endosome membrane
BBB0070062cellular_componentextracellular exosome
BBB0071281biological_processcellular response to iron ion
BBB0071316biological_processcellular response to nicotine
BBB1904724cellular_componenttertiary granule lumen
BBB1990000biological_processamyloid fibril formation
BBB1990712cellular_componentHFE-transferrin receptor complex
BBB2000774biological_processpositive regulation of cellular senescence
BBB2000978biological_processnegative regulation of forebrain neuron differentiation
EEE0002250biological_processadaptive immune response
EEE0002376biological_processimmune system process
EEE0005886cellular_componentplasma membrane
EEE0042101cellular_componentT cell receptor complex
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH
ChainResidueDetails
AAATYR257-HIS263
BBBTYR78-HIS84
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues176
DetailsDomain: {"description":"Ig-like C1-type"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues89
DetailsRegion: {"description":"Alpha-1"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues91
DetailsRegion: {"description":"Alpha-2"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues91
DetailsRegion: {"description":"Alpha-3"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30087334","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35705051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7P4B","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35705051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7P49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P4B","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35705051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7P4B","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18339401","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsRegion: {"description":"CDR1","evidences":[{"source":"PubMed","id":"12796775","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27036003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11096259","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsRegion: {"description":"CDR2","evidences":[{"source":"PubMed","id":"12796775","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27036003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11096259","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"UniProtKB","id":"P01848","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues93
DetailsDomain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-12-24

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