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7NAQ

Human PA200-20S proteasome complex

Functional Information from GO Data
ChainGOidnamespacecontents
a0000502cellular_componentproteasome complex
a0001530molecular_functionlipopolysaccharide binding
a0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
a0005515molecular_functionprotein binding
a0005634cellular_componentnucleus
a0005654cellular_componentnucleoplasm
a0005737cellular_componentcytoplasm
a0005739cellular_componentmitochondrion
a0005829cellular_componentcytosol
a0005839cellular_componentproteasome core complex
a0019774cellular_componentproteasome core complex, beta-subunit complex
a0036064cellular_componentciliary basal body
a0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
a0051603biological_processproteolysis involved in protein catabolic process
a0070062cellular_componentextracellular exosome
A0000502cellular_componentproteasome complex
A0000932cellular_componentP-body
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005839cellular_componentproteasome core complex
A0006511biological_processubiquitin-dependent protein catabolic process
A0009615biological_processresponse to virus
A0019773cellular_componentproteasome core complex, alpha-subunit complex
A0034774cellular_componentsecretory granule lumen
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0051603biological_processproteolysis involved in protein catabolic process
A0070062cellular_componentextracellular exosome
A1904813cellular_componentficolin-1-rich granule lumen
b0000502cellular_componentproteasome complex
b0004175molecular_functionendopeptidase activity
b0004298molecular_functionthreonine-type endopeptidase activity
b0005515molecular_functionprotein binding
b0005634cellular_componentnucleus
b0005654cellular_componentnucleoplasm
b0005737cellular_componentcytoplasm
b0005739cellular_componentmitochondrion
b0005829cellular_componentcytosol
b0005839cellular_componentproteasome core complex
b0006508biological_processproteolysis
b0019774cellular_componentproteasome core complex, beta-subunit complex
b0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
b0045296molecular_functioncadherin binding
b0051603biological_processproteolysis involved in protein catabolic process
b0070062cellular_componentextracellular exosome
B0000502cellular_componentproteasome complex
B0000932cellular_componentP-body
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005839cellular_componentproteasome core complex
B0006511biological_processubiquitin-dependent protein catabolic process
B0019773cellular_componentproteasome core complex, alpha-subunit complex
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043231cellular_componentintracellular membrane-bounded organelle
B0051603biological_processproteolysis involved in protein catabolic process
B0070062cellular_componentextracellular exosome
c0000502cellular_componentproteasome complex
c0005515molecular_functionprotein binding
c0005634cellular_componentnucleus
c0005654cellular_componentnucleoplasm
c0005737cellular_componentcytoplasm
c0005829cellular_componentcytosol
c0006281biological_processDNA repair
c0006974biological_processDNA damage response
c0007283biological_processspermatogenesis
c0010499biological_processproteasomal ubiquitin-independent protein catabolic process
c0016504molecular_functionpeptidase activator activity
c0016607cellular_componentnuclear speck
c0030154biological_processcell differentiation
c0035092biological_processsperm DNA condensation
c0070577molecular_functionlysine-acetylated histone binding
c0070628molecular_functionproteasome binding
c1990111cellular_componentspermatoproteasome complex
C0000502cellular_componentproteasome complex
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005839cellular_componentproteasome core complex
C0006511biological_processubiquitin-dependent protein catabolic process
C0019773cellular_componentproteasome core complex, alpha-subunit complex
C0042802molecular_functionidentical protein binding
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0051603biological_processproteolysis involved in protein catabolic process
C0070062cellular_componentextracellular exosome
C0098794cellular_componentpostsynapse
D0000502cellular_componentproteasome complex
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005839cellular_componentproteasome core complex
D0006511biological_processubiquitin-dependent protein catabolic process
D0019773cellular_componentproteasome core complex, alpha-subunit complex
D0034774cellular_componentsecretory granule lumen
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0051603biological_processproteolysis involved in protein catabolic process
D0070062cellular_componentextracellular exosome
D1904813cellular_componentficolin-1-rich granule lumen
E0000502cellular_componentproteasome complex
E0001530molecular_functionlipopolysaccharide binding
E0002376biological_processimmune system process
E0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005829cellular_componentcytosol
E0005839cellular_componentproteasome core complex
E0006511biological_processubiquitin-dependent protein catabolic process
E0019773cellular_componentproteasome core complex, alpha-subunit complex
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0051603biological_processproteolysis involved in protein catabolic process
E0070062cellular_componentextracellular exosome
F0000502cellular_componentproteasome complex
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005839cellular_componentproteasome core complex
F0006511biological_processubiquitin-dependent protein catabolic process
F0019773cellular_componentproteasome core complex, alpha-subunit complex
F0031625molecular_functionubiquitin protein ligase binding
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0045202cellular_componentsynapse
F0051603biological_processproteolysis involved in protein catabolic process
F0052548biological_processregulation of endopeptidase activity
F0070062cellular_componentextracellular exosome
G0000502cellular_componentproteasome complex
G0000932cellular_componentP-body
G0003723molecular_functionRNA binding
G0004175molecular_functionendopeptidase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005839cellular_componentproteasome core complex
G0005840cellular_componentribosome
G0006511biological_processubiquitin-dependent protein catabolic process
G0016363cellular_componentnuclear matrix
G0019773cellular_componentproteasome core complex, alpha-subunit complex
G0030016cellular_componentmyofibril
G0030017cellular_componentsarcomere
G0035639molecular_functionpurine ribonucleoside triphosphate binding
G0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
G0050727biological_processregulation of inflammatory response
G0051059molecular_functionNF-kappaB binding
G0051092biological_processpositive regulation of NF-kappaB transcription factor activity
G0051603biological_processproteolysis involved in protein catabolic process
G0070062cellular_componentextracellular exosome
H0000502cellular_componentproteasome complex
H0004175molecular_functionendopeptidase activity
H0004298molecular_functionthreonine-type endopeptidase activity
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005839cellular_componentproteasome core complex
H0006508biological_processproteolysis
H0016604cellular_componentnuclear body
H0019774cellular_componentproteasome core complex, beta-subunit complex
H0034774cellular_componentsecretory granule lumen
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0051603biological_processproteolysis involved in protein catabolic process
H1904813cellular_componentficolin-1-rich granule lumen
I0000502cellular_componentproteasome complex
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005839cellular_componentproteasome core complex
I0019774cellular_componentproteasome core complex, beta-subunit complex
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0051603biological_processproteolysis involved in protein catabolic process
I0070062cellular_componentextracellular exosome
J0000502cellular_componentproteasome complex
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005839cellular_componentproteasome core complex
J0010243biological_processresponse to organonitrogen compound
J0010498biological_processproteasomal protein catabolic process
J0014070biological_processresponse to organic cyclic compound
J0016020cellular_componentmembrane
J0019774cellular_componentproteasome core complex, beta-subunit complex
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0051603biological_processproteolysis involved in protein catabolic process
J0070062cellular_componentextracellular exosome
K0000502cellular_componentproteasome complex
K0004175molecular_functionendopeptidase activity
K0004298molecular_functionthreonine-type endopeptidase activity
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005813cellular_componentcentrosome
K0005829cellular_componentcytosol
K0005839cellular_componentproteasome core complex
K0006508biological_processproteolysis
K0006979biological_processresponse to oxidative stress
K0008233molecular_functionpeptidase activity
K0019774cellular_componentproteasome core complex, beta-subunit complex
K0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K0051603biological_processproteolysis involved in protein catabolic process
K0070062cellular_componentextracellular exosome
L0000502cellular_componentproteasome complex
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0005839cellular_componentproteasome core complex
L0019774cellular_componentproteasome core complex, beta-subunit complex
L0034774cellular_componentsecretory granule lumen
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
L0051603biological_processproteolysis involved in protein catabolic process
L0070062cellular_componentextracellular exosome
L1904813cellular_componentficolin-1-rich granule lumen
M0000502cellular_componentproteasome complex
M0001530molecular_functionlipopolysaccharide binding
M0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0005737cellular_componentcytoplasm
M0005739cellular_componentmitochondrion
M0005829cellular_componentcytosol
M0005839cellular_componentproteasome core complex
M0019774cellular_componentproteasome core complex, beta-subunit complex
M0036064cellular_componentciliary basal body
M0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0051603biological_processproteolysis involved in protein catabolic process
M0070062cellular_componentextracellular exosome
N0000502cellular_componentproteasome complex
N0004175molecular_functionendopeptidase activity
N0004298molecular_functionthreonine-type endopeptidase activity
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005737cellular_componentcytoplasm
N0005739cellular_componentmitochondrion
N0005829cellular_componentcytosol
N0005839cellular_componentproteasome core complex
N0006508biological_processproteolysis
N0019774cellular_componentproteasome core complex, beta-subunit complex
N0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
N0045296molecular_functioncadherin binding
N0051603biological_processproteolysis involved in protein catabolic process
N0070062cellular_componentextracellular exosome
O0000502cellular_componentproteasome complex
O0000932cellular_componentP-body
O0005515molecular_functionprotein binding
O0005576cellular_componentextracellular region
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005737cellular_componentcytoplasm
O0005829cellular_componentcytosol
O0005839cellular_componentproteasome core complex
O0006511biological_processubiquitin-dependent protein catabolic process
O0009615biological_processresponse to virus
O0019773cellular_componentproteasome core complex, alpha-subunit complex
O0034774cellular_componentsecretory granule lumen
O0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
O0051603biological_processproteolysis involved in protein catabolic process
O0070062cellular_componentextracellular exosome
O1904813cellular_componentficolin-1-rich granule lumen
P0000502cellular_componentproteasome complex
P0000932cellular_componentP-body
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005654cellular_componentnucleoplasm
P0005737cellular_componentcytoplasm
P0005829cellular_componentcytosol
P0005839cellular_componentproteasome core complex
P0006511biological_processubiquitin-dependent protein catabolic process
P0019773cellular_componentproteasome core complex, alpha-subunit complex
P0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
P0043231cellular_componentintracellular membrane-bounded organelle
P0051603biological_processproteolysis involved in protein catabolic process
P0070062cellular_componentextracellular exosome
Q0000502cellular_componentproteasome complex
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005654cellular_componentnucleoplasm
Q0005737cellular_componentcytoplasm
Q0005829cellular_componentcytosol
Q0005839cellular_componentproteasome core complex
Q0006511biological_processubiquitin-dependent protein catabolic process
Q0019773cellular_componentproteasome core complex, alpha-subunit complex
Q0042802molecular_functionidentical protein binding
Q0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Q0051603biological_processproteolysis involved in protein catabolic process
Q0070062cellular_componentextracellular exosome
Q0098794cellular_componentpostsynapse
R0000502cellular_componentproteasome complex
R0005515molecular_functionprotein binding
R0005576cellular_componentextracellular region
R0005634cellular_componentnucleus
R0005654cellular_componentnucleoplasm
R0005737cellular_componentcytoplasm
R0005829cellular_componentcytosol
R0005839cellular_componentproteasome core complex
R0006511biological_processubiquitin-dependent protein catabolic process
R0019773cellular_componentproteasome core complex, alpha-subunit complex
R0034774cellular_componentsecretory granule lumen
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0051603biological_processproteolysis involved in protein catabolic process
R0070062cellular_componentextracellular exosome
R1904813cellular_componentficolin-1-rich granule lumen
S0000502cellular_componentproteasome complex
S0001530molecular_functionlipopolysaccharide binding
S0002376biological_processimmune system process
S0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
S0005515molecular_functionprotein binding
S0005634cellular_componentnucleus
S0005654cellular_componentnucleoplasm
S0005737cellular_componentcytoplasm
S0005813cellular_componentcentrosome
S0005829cellular_componentcytosol
S0005839cellular_componentproteasome core complex
S0006511biological_processubiquitin-dependent protein catabolic process
S0019773cellular_componentproteasome core complex, alpha-subunit complex
S0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
S0051603biological_processproteolysis involved in protein catabolic process
S0070062cellular_componentextracellular exosome
T0000502cellular_componentproteasome complex
T0005515molecular_functionprotein binding
T0005634cellular_componentnucleus
T0005654cellular_componentnucleoplasm
T0005737cellular_componentcytoplasm
T0005829cellular_componentcytosol
T0005839cellular_componentproteasome core complex
T0006511biological_processubiquitin-dependent protein catabolic process
T0019773cellular_componentproteasome core complex, alpha-subunit complex
T0031625molecular_functionubiquitin protein ligase binding
T0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
T0045202cellular_componentsynapse
T0051603biological_processproteolysis involved in protein catabolic process
T0052548biological_processregulation of endopeptidase activity
T0070062cellular_componentextracellular exosome
U0000502cellular_componentproteasome complex
U0000932cellular_componentP-body
U0003723molecular_functionRNA binding
U0004175molecular_functionendopeptidase activity
U0005515molecular_functionprotein binding
U0005634cellular_componentnucleus
U0005654cellular_componentnucleoplasm
U0005737cellular_componentcytoplasm
U0005829cellular_componentcytosol
U0005839cellular_componentproteasome core complex
U0005840cellular_componentribosome
U0006511biological_processubiquitin-dependent protein catabolic process
U0016363cellular_componentnuclear matrix
U0019773cellular_componentproteasome core complex, alpha-subunit complex
U0030016cellular_componentmyofibril
U0030017cellular_componentsarcomere
U0035639molecular_functionpurine ribonucleoside triphosphate binding
U0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
U0050727biological_processregulation of inflammatory response
U0051059molecular_functionNF-kappaB binding
U0051092biological_processpositive regulation of NF-kappaB transcription factor activity
U0051603biological_processproteolysis involved in protein catabolic process
U0070062cellular_componentextracellular exosome
V0000502cellular_componentproteasome complex
V0004175molecular_functionendopeptidase activity
V0004298molecular_functionthreonine-type endopeptidase activity
V0005515molecular_functionprotein binding
V0005576cellular_componentextracellular region
V0005634cellular_componentnucleus
V0005654cellular_componentnucleoplasm
V0005737cellular_componentcytoplasm
V0005829cellular_componentcytosol
V0005839cellular_componentproteasome core complex
V0006508biological_processproteolysis
V0016604cellular_componentnuclear body
V0019774cellular_componentproteasome core complex, beta-subunit complex
V0034774cellular_componentsecretory granule lumen
V0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
V0051603biological_processproteolysis involved in protein catabolic process
V1904813cellular_componentficolin-1-rich granule lumen
W0000502cellular_componentproteasome complex
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005654cellular_componentnucleoplasm
W0005737cellular_componentcytoplasm
W0005829cellular_componentcytosol
W0005839cellular_componentproteasome core complex
W0019774cellular_componentproteasome core complex, beta-subunit complex
W0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
W0051603biological_processproteolysis involved in protein catabolic process
W0070062cellular_componentextracellular exosome
X0000502cellular_componentproteasome complex
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005654cellular_componentnucleoplasm
X0005737cellular_componentcytoplasm
X0005829cellular_componentcytosol
X0005839cellular_componentproteasome core complex
X0010243biological_processresponse to organonitrogen compound
X0010498biological_processproteasomal protein catabolic process
X0014070biological_processresponse to organic cyclic compound
X0016020cellular_componentmembrane
X0019774cellular_componentproteasome core complex, beta-subunit complex
X0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
X0051603biological_processproteolysis involved in protein catabolic process
X0070062cellular_componentextracellular exosome
Y0000502cellular_componentproteasome complex
Y0004175molecular_functionendopeptidase activity
Y0004298molecular_functionthreonine-type endopeptidase activity
Y0005515molecular_functionprotein binding
Y0005634cellular_componentnucleus
Y0005654cellular_componentnucleoplasm
Y0005737cellular_componentcytoplasm
Y0005813cellular_componentcentrosome
Y0005829cellular_componentcytosol
Y0005839cellular_componentproteasome core complex
Y0006508biological_processproteolysis
Y0006979biological_processresponse to oxidative stress
Y0008233molecular_functionpeptidase activity
Y0019774cellular_componentproteasome core complex, beta-subunit complex
Y0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Y0051603biological_processproteolysis involved in protein catabolic process
Y0070062cellular_componentextracellular exosome
Z0000502cellular_componentproteasome complex
Z0005515molecular_functionprotein binding
Z0005576cellular_componentextracellular region
Z0005634cellular_componentnucleus
Z0005654cellular_componentnucleoplasm
Z0005737cellular_componentcytoplasm
Z0005829cellular_componentcytosol
Z0005839cellular_componentproteasome core complex
Z0019774cellular_componentproteasome core complex, beta-subunit complex
Z0034774cellular_componentsecretory granule lumen
Z0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Z0051603biological_processproteolysis involved in protein catabolic process
Z0070062cellular_componentextracellular exosome
Z1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PROSITE/UniProt
site_idPS00388
Number of Residues23
DetailsPROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdndvTvWSPqGRihQIEYAmeA
ChainResidueDetails
ETYR6-ALA28
BTYR5-ALA27
GPHE9-ALA31
ATYR5-ALA27
DTYR8-ALA30
CTYR3-ALA25
FTYR7-ALA29

site_idPS00854
Number of Residues48
DetailsPROTEASOME_BETA_1 Proteasome beta-type subunits signature. LAFkFrhGVIVAADsratagayiasqtvk.KvieinpyllgtmaGgaAD
ChainResidueDetails
KLEU4-ASP51
bMET4-ASP51
BLEU35-ASP82
aLEU12-ASP59
LLEU13-ASP60
HALA4-ASP51
IMET11-ASP58
JILE5-ASP52

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylserine => ECO:0000269|Ref.3, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895
ChainResidueDetails
ISER1
WSER1
GSER64
USER17
USER63
USER64

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ILYS76
WLYS76
ULYS102
ULYS104
TLYS205
TLYS229

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9QUM9
ChainResidueDetails
GTYR159
UTYR159
PLYS127
PLYS176
OSER13
OSER15

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000250
ChainResidueDetails
GSER5
USER5

site_idSWS_FT_FI5
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
ELYS115
RSER63
ELYS208
SLYS115
SLYS208

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000250
ChainResidueDetails
DSER186
RSER198

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P17220
ChainResidueDetails
ATYR120
OTYR120

222926

PDB entries from 2024-07-24

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