7NA9

Crystal structure of BoNT/B-LC-JSG-C1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. WSgDRTYCAD

Chain	Residue	Details
D	TRP53-ASP62

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site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. ILMHELIHVL

Chain	Residue	Details
A	ILE227-LEU236

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
A	GLU231

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:10932256, ECO:0000305|PubMed:1429690, ECO:0007744|PDB:1EPW, ECO:0007744|PDB:1F31, ECO:0007744|PDB:2NP0

Chain	Residue	Details
A	HIS230
A	HIS234

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:10932256, ECO:0007744|PDB:1EPW, ECO:0007744|PDB:1F31, ECO:0007744|PDB:2NP0

Chain	Residue	Details
A	GLU268

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 626

Chain	Residue	Details
A	HIS230	metal ligand
A	GLU231	proton acceptor, proton donor
A	HIS234	metal ligand
A	GLU268	metal ligand
A	ARG370	electrostatic stabiliser

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