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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7N9X

CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AAA0016032biological_processviral process
BBB0016032biological_processviral process
CCC0016032biological_processviral process
GGG0000413biological_processprotein peptidyl-prolyl isomerization
GGG0001933biological_processnegative regulation of protein phosphorylation
GGG0001934biological_processpositive regulation of protein phosphorylation
GGG0003723molecular_functionRNA binding
GGG0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
GGG0005178molecular_functionintegrin binding
GGG0005515molecular_functionprotein binding
GGG0005576cellular_componentextracellular region
GGG0005615cellular_componentextracellular space
GGG0005634cellular_componentnucleus
GGG0005737cellular_componentcytoplasm
GGG0005829cellular_componentcytosol
GGG0005886cellular_componentplasma membrane
GGG0005925cellular_componentfocal adhesion
GGG0006457biological_processprotein folding
GGG0006469biological_processnegative regulation of protein kinase activity
GGG0006915biological_processapoptotic process
GGG0016018molecular_functioncyclosporin A binding
GGG0016020cellular_componentmembrane
GGG0016853molecular_functionisomerase activity
GGG0019076biological_processviral release from host cell
GGG0030168biological_processplatelet activation
GGG0030593biological_processneutrophil chemotaxis
GGG0030595biological_processleukocyte chemotaxis
GGG0031982cellular_componentvesicle
GGG0032148biological_processactivation of protein kinase B activity
GGG0032873biological_processnegative regulation of stress-activated MAPK cascade
GGG0032991cellular_componentprotein-containing complex
GGG0034389biological_processlipid droplet organization
GGG0034599biological_processcellular response to oxidative stress
GGG0034774cellular_componentsecretory granule lumen
GGG0042118biological_processendothelial cell activation
GGG0043410biological_processpositive regulation of MAPK cascade
GGG0045069biological_processregulation of viral genome replication
GGG0045070biological_processpositive regulation of viral genome replication
GGG0046790molecular_functionvirion binding
GGG0050714biological_processpositive regulation of protein secretion
GGG0051082molecular_functionunfolded protein binding
GGG0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
GGG0060352biological_processcell adhesion molecule production
GGG0061944biological_processnegative regulation of protein K48-linked ubiquitination
GGG0070062cellular_componentextracellular exosome
GGG0070527biological_processplatelet aggregation
GGG1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GGG1903901biological_processnegative regulation of viral life cycle
GGG1904399molecular_functionheparan sulfate binding
GGG1904813cellular_componentficolin-1-rich granule lumen
GGG2001233biological_processregulation of apoptotic signaling pathway
HHH0000413biological_processprotein peptidyl-prolyl isomerization
HHH0001933biological_processnegative regulation of protein phosphorylation
HHH0001934biological_processpositive regulation of protein phosphorylation
HHH0003723molecular_functionRNA binding
HHH0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
HHH0005178molecular_functionintegrin binding
HHH0005515molecular_functionprotein binding
HHH0005576cellular_componentextracellular region
HHH0005615cellular_componentextracellular space
HHH0005634cellular_componentnucleus
HHH0005737cellular_componentcytoplasm
HHH0005829cellular_componentcytosol
HHH0005886cellular_componentplasma membrane
HHH0005925cellular_componentfocal adhesion
HHH0006457biological_processprotein folding
HHH0006469biological_processnegative regulation of protein kinase activity
HHH0006915biological_processapoptotic process
HHH0016018molecular_functioncyclosporin A binding
HHH0016020cellular_componentmembrane
HHH0016853molecular_functionisomerase activity
HHH0019076biological_processviral release from host cell
HHH0030168biological_processplatelet activation
HHH0030593biological_processneutrophil chemotaxis
HHH0030595biological_processleukocyte chemotaxis
HHH0031982cellular_componentvesicle
HHH0032148biological_processactivation of protein kinase B activity
HHH0032873biological_processnegative regulation of stress-activated MAPK cascade
HHH0032991cellular_componentprotein-containing complex
HHH0034389biological_processlipid droplet organization
HHH0034599biological_processcellular response to oxidative stress
HHH0034774cellular_componentsecretory granule lumen
HHH0042118biological_processendothelial cell activation
HHH0043410biological_processpositive regulation of MAPK cascade
HHH0045069biological_processregulation of viral genome replication
HHH0045070biological_processpositive regulation of viral genome replication
HHH0046790molecular_functionvirion binding
HHH0050714biological_processpositive regulation of protein secretion
HHH0051082molecular_functionunfolded protein binding
HHH0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
HHH0060352biological_processcell adhesion molecule production
HHH0061944biological_processnegative regulation of protein K48-linked ubiquitination
HHH0070062cellular_componentextracellular exosome
HHH0070527biological_processplatelet aggregation
HHH1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
HHH1903901biological_processnegative regulation of viral life cycle
HHH1904399molecular_functionheparan sulfate binding
HHH1904813cellular_componentficolin-1-rich granule lumen
HHH2001233biological_processregulation of apoptotic signaling pathway
III0000413biological_processprotein peptidyl-prolyl isomerization
III0001933biological_processnegative regulation of protein phosphorylation
III0001934biological_processpositive regulation of protein phosphorylation
III0003723molecular_functionRNA binding
III0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
III0005178molecular_functionintegrin binding
III0005515molecular_functionprotein binding
III0005576cellular_componentextracellular region
III0005615cellular_componentextracellular space
III0005634cellular_componentnucleus
III0005737cellular_componentcytoplasm
III0005829cellular_componentcytosol
III0005886cellular_componentplasma membrane
III0005925cellular_componentfocal adhesion
III0006457biological_processprotein folding
III0006469biological_processnegative regulation of protein kinase activity
III0006915biological_processapoptotic process
III0016018molecular_functioncyclosporin A binding
III0016020cellular_componentmembrane
III0016853molecular_functionisomerase activity
III0019076biological_processviral release from host cell
III0030168biological_processplatelet activation
III0030593biological_processneutrophil chemotaxis
III0030595biological_processleukocyte chemotaxis
III0031982cellular_componentvesicle
III0032148biological_processactivation of protein kinase B activity
III0032873biological_processnegative regulation of stress-activated MAPK cascade
III0032991cellular_componentprotein-containing complex
III0034389biological_processlipid droplet organization
III0034599biological_processcellular response to oxidative stress
III0034774cellular_componentsecretory granule lumen
III0042118biological_processendothelial cell activation
III0043410biological_processpositive regulation of MAPK cascade
III0045069biological_processregulation of viral genome replication
III0045070biological_processpositive regulation of viral genome replication
III0046790molecular_functionvirion binding
III0050714biological_processpositive regulation of protein secretion
III0051082molecular_functionunfolded protein binding
III0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
III0060352biological_processcell adhesion molecule production
III0061944biological_processnegative regulation of protein K48-linked ubiquitination
III0070062cellular_componentextracellular exosome
III0070527biological_processplatelet aggregation
III1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
III1903901biological_processnegative regulation of viral life cycle
III1904399molecular_functionheparan sulfate binding
III1904813cellular_componentficolin-1-rich granule lumen
III2001233biological_processregulation of apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00170
Number of Residues18
DetailsCSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgScFHRIIpgFMcQGG
ChainResidueDetails
GGGTYR48-GLY65
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI2
Number of Residues468
DetailsDomain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"N-acetylvaline; partial; in Peptidyl-prolyl cis-trans isomerase A, N-terminally processed","evidences":[{"source":"PubMed","id":"25489052","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Claeys D."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues9
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues3
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"20364129","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25678563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P17742","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues3
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues6
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
site_idMCSA2
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails
site_idMCSA3
Number of Residues7
DetailsM-CSA 189
ChainResidueDetails

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PDB entries from 2026-03-18

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