7N9Q
State 3 of TcdB and FZD2 at pH5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0008289 | molecular_function | lipid binding |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0020002 | cellular_component | host cell plasma membrane |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0044164 | cellular_component | host cell cytosol |
| A | 0044174 | cellular_component | host cell endosome |
| A | 0044175 | cellular_component | host cell endosome membrane |
| A | 0046527 | molecular_function | glucosyltransferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0090729 | molecular_function | toxin activity |
| A | 0141030 | biological_process | symbiont-mediated perturbation of host actin cytoskeleton via filamentous actin depolymerization |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 372 |
| Details | Domain: {"description":"GT44","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 207 |
| Details | Domain: {"description":"Peptidase C80","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | Repeat: {"description":"Cell wall-binding 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 22 |
| Details | Repeat: {"description":"Cell wall-binding 13"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 14"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 15"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 16"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 17"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 18"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 89 |
| Details | Region: {"description":"Four-helical bundle","evidences":[{"source":"PubMed","id":"25882477","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 372 |
| Details | Region: {"description":"Glucosyltransferase region","evidences":[{"source":"PubMed","id":"29146177","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 255 |
| Details | Region: {"description":"Autoprocessing region","evidences":[{"source":"PubMed","id":"29146177","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 32 |
| Details | Region: {"description":"Interaction with host frizzled receptors FZD1, FZD2 and FZD7","evidences":[{"source":"PubMed","id":"29748286","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 532 |
| Details | Region: {"description":"Receptor-binding (CROPS) region","evidences":[{"source":"PubMed","id":"29146177","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27571750","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; for protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27571750","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16054646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28433497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31308519","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OQ7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16054646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28433497","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31308519","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6OQ5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI31 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16054646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28433497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31308519","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2BVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OQ7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI32 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P16154","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI33 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31308519","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OQ5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI34 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31308519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27571750","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6OQ5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI35 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by autolysis","evidences":[{"source":"PubMed","id":"15632438","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
