7N9Q
State 3 of TcdB and FZD2 at pH5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0008289 | molecular_function | lipid binding |
| A | 0016020 | cellular_component | membrane |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0020002 | cellular_component | host cell plasma membrane |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0044164 | cellular_component | host cell cytosol |
| A | 0044174 | cellular_component | host cell endosome |
| A | 0044175 | cellular_component | host cell endosome membrane |
| A | 0046527 | molecular_function | glucosyltransferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0090729 | molecular_function | toxin activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: For protease activity => ECO:0000255|PROSITE-ProRule:PRU01107, ECO:0000269|PubMed:27571750 |
| Chain | Residue | Details |
| A | HIS653 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile; for protease activity => ECO:0000255|PROSITE-ProRule:PRU01107, ECO:0000269|PubMed:27571750 |
| Chain | Residue | Details |
| A | CYS698 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16054646, ECO:0000269|PubMed:28433497, ECO:0000269|PubMed:31308519, ECO:0007744|PDB:2BVL, ECO:0007744|PDB:2BVM, ECO:0007744|PDB:5UQM, ECO:0007744|PDB:5UQN, ECO:0007744|PDB:6OQ7 |
| Chain | Residue | Details |
| A | VAL101 | |
| A | SER269 | |
| A | SER518 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16054646, ECO:0000269|PubMed:28433497, ECO:0007744|PDB:2BVL, ECO:0007744|PDB:2BVM, ECO:0007744|PDB:5UQM, ECO:0007744|PDB:5UQN |
| Chain | Residue | Details |
| A | ASN139 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:31308519, ECO:0007744|PDB:6OQ5 |
| Chain | Residue | Details |
| A | ASP286 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16054646, ECO:0000269|PubMed:28433497, ECO:0000305|PubMed:31308519, ECO:0007744|PDB:2BVL, ECO:0007744|PDB:5UQM, ECO:0007744|PDB:5UQN, ECO:0007744|PDB:5UQT, ECO:0007744|PDB:6OQ7 |
| Chain | Residue | Details |
| A | ASP288 | |
| A | GLU515 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P16154 |
| Chain | Residue | Details |
| A | GLU545 | |
| A | TYR577 | |
| A | LYS600 | |
| A | LYS647 | |
| A | LYS764 | |
| A | LYS775 | |
| A | LYS792 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31308519, ECO:0007744|PDB:6OQ5 |
| Chain | Residue | Details |
| A | ASP546 | |
| A | HIS653 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31308519, ECO:0000305|PubMed:27571750, ECO:0007744|PDB:6OQ5 |
| Chain | Residue | Details |
| A | HIS757 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by autolysis => ECO:0000269|PubMed:15632438 |
| Chain | Residue | Details |
| A | LEU543 |
