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7N98

Cryo-EM structure of MFSD2A

Functional Information from GO Data
ChainGOidnamespacecontents
A0003406biological_processretinal pigment epithelium development
A0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0007420biological_processbrain development
A0008594biological_processphotoreceptor cell morphogenesis
A0008643biological_processcarbohydrate transport
A0009267biological_processcellular response to starvation
A0010867biological_processpositive regulation of triglyceride biosynthetic process
A0015245molecular_functionfatty acid transmembrane transporter activity
A0015293molecular_functionsymporter activity
A0015908biological_processfatty acid transport
A0015909biological_processlong-chain fatty acid transport
A0016020cellular_componentmembrane
A0021766biological_processhippocampus development
A0030307biological_processpositive regulation of cell growth
A0031999biological_processnegative regulation of fatty acid beta-oxidation
A0034379biological_processvery-low-density lipoprotein particle assembly
A0035633biological_processmaintenance of blood-brain barrier
A0035845biological_processphotoreceptor cell outer segment organization
A0040014biological_processregulation of multicellular organism growth
A0045056biological_processtranscytosis
A0050773biological_processregulation of dendrite development
A0050890biological_processcognition
A0051977biological_processlysophospholipid transport
A0051978molecular_functionlysophospholipid:sodium symporter activity
A0055085biological_processtransmembrane transport
A0060042biological_processretina morphogenesis in camera-type eye
A0060856biological_processestablishment of blood-brain barrier
A0061744biological_processmotor behavior
A0097009biological_processenergy homeostasis
A0140329biological_processlysophospholipid translocation
A0140348molecular_functionlysophosphatidylcholine flippase activity
A0150011biological_processregulation of neuron projection arborization
A0150172biological_processregulation of phosphatidylcholine metabolic process
A0150175biological_processregulation of phosphatidylethanolamine metabolic process
A0150178biological_processregulation of phosphatidylserine metabolic process
A1901480molecular_functionoleate transmembrane transporter activity
A1990379biological_processlipid transport across blood-brain barrier
A1990403biological_processembryonic brain development
A1990963biological_processestablishment of blood-retinal barrier
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues137
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98
ChainResidueDetails
AMET1-GLN39
ACYS102-ARG113
AMET174-GLN180
AGLY267-PRO297
ALEU355-PHE358
AHIS421-ILE430
ALYS494-LEU534

site_idSWS_FT_FI2
Number of Residues306
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98
ChainResidueDetails
ALEU40-TYR69
AASN384-LYS420
APHE431-ALA457
AVAL470-PHE493
AALA81-PHE101
ALEU114-TRP133
ALEU149-THR173
ASER181-ALA212
ATHR233-LEU266
ATYR298-THR324
ALEU336-PHE354
AGLY359-LEU380

site_idSWS_FT_FI3
Number of Residues66
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:34349262, ECO:0007744|PDB:7N98
ChainResidueDetails
ALEU70-PRO80
APHE134-PHE148
ALYS213-ARG232
ATYR325-ASN335
AMET381-ARG383
AASN458-GLN469

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN221
AASN231

219515

PDB entries from 2024-05-08

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