7N98

Cryo-EM structure of MFSD2A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003406	biological_process	retinal pigment epithelium development
A	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
A	0005764	cellular_component	lysosome
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006869	biological_process	lipid transport
A	0007420	biological_process	brain development
A	0008594	biological_process	photoreceptor cell morphogenesis
A	0008643	biological_process	carbohydrate transport
A	0009267	biological_process	cellular response to starvation
A	0010867	biological_process	positive regulation of triglyceride biosynthetic process
A	0015245	molecular_function	fatty acid transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015908	biological_process	fatty acid transport
A	0015909	biological_process	long-chain fatty acid transport
A	0016020	cellular_component	membrane
A	0021766	biological_process	hippocampus development
A	0030307	biological_process	positive regulation of cell growth
A	0031999	biological_process	negative regulation of fatty acid beta-oxidation
A	0034204	biological_process	lipid translocation
A	0034379	biological_process	very-low-density lipoprotein particle assembly
A	0035633	biological_process	maintenance of blood-brain barrier
A	0035845	biological_process	photoreceptor cell outer segment organization
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0040014	biological_process	regulation of multicellular organism growth
A	0045056	biological_process	transcytosis
A	0050773	biological_process	regulation of dendrite development
A	0050890	biological_process	cognition
A	0051977	biological_process	lysophospholipid transport
A	0051978	molecular_function	lysophospholipid:sodium symporter activity
A	0055085	biological_process	transmembrane transport
A	0060042	biological_process	retina morphogenesis in camera-type eye
A	0060856	biological_process	establishment of blood-brain barrier
A	0061744	biological_process	motor behavior
A	0097009	biological_process	energy homeostasis
A	0140329	biological_process	lysophospholipid translocation
A	0140348	molecular_function	lysophosphatidylcholine flippase activity
A	0150011	biological_process	regulation of neuron projection arborization
A	0150172	biological_process	regulation of phosphatidylcholine metabolic process
A	0150175	biological_process	regulation of phosphatidylethanolamine metabolic process
A	1901480	molecular_function	oleate transmembrane transporter activity
A	1990379	biological_process	lipid transport across blood-brain barrier
A	1990403	biological_process	embryonic brain development
A	1990963	biological_process	establishment of blood-retinal barrier

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	306
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"34349262","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7N98","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	66
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34349262","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7N98","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	59
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34349262","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7N98","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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